A systematic review-meta-analysis and meta-regression on the effect of selected competitive exclusion products on Salmonella spp. prevalence and concentration in broiler chickens

Kerr, Ashley; Farrar, Ashley M.; Waddell, Lisa; Wilkins, Wendy; Wilhelm, Barbara; Bucher, Oliver; Wills, Robert W.; Bailey, R. H.; Varga, Csaba; McEwen, Scott A.; Rajić, Andrijana

doi:10.1016/j.prevetmed.2013.04.005

Cited by 44 publications

(33 citation statements)

References 39 publications

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“…In some countries, competitive exclusion has been successfully employed to limit the colonization of chickens with Salmonella and Escherichia coli [14,15]. Potential competitive exclusion strategies to limit the prevalence of C. jejuni have also been investigated, with some degree of success [16-18].…”

Section: Introductionmentioning

confidence: 99%

The interplay between Campylobacter and Helicobacter species and other gastrointestinal microbiota of commercial broiler chickens

Kaakoush

Sodhi

Chenu³

et al. 2014

Gut Pathog

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BackgroundPoultry represent an important source of foodborne enteropathogens, in particular thermophilic Campylobacter species. Many of these organisms colonize the intestinal tract of broiler chickens as harmless commensals, and therefore, often remain undetected prior to slaughter. The exact reasons for the lack of clinical disease are unknown, but analysis of the gastrointestinal microbiota of broiler chickens may improve our understanding of the microbial interactions with the host.MethodsIn this study, the fecal microbiota of 31 market-age (56-day old) broiler chickens, from two different farms, was analyzed using high throughput sequencing. The samples were then screened for two emerging human pathogens, Campylobacter concisus and Helicobacter pullorum, using species-specific PCR.ResultsThe gastrointestinal microbiota of chickens was classified into four potential enterotypes, similar to that of humans, where three enterotypes have been identified. The results indicated that variations between farms may have contributed to differences in the microbiota, though each of the four enterotypes were found in both farms suggesting that these groupings did not occur by chance. In addition to the identification of Campylobacter jejuni subspecies doylei and the emerging species, C. concisus, C. upsaliensis and H. pullorum, several differences in the prevalence of human pathogens within these enterotypes were observed. Further analysis revealed microbial taxa with the potential to increase the likelihood of colonization by a number of these pathogens, including C. jejuni.ConclusionDepletion of these taxa and the addition of taxa that compete with these pathogens, may form the basis of competitive exclusion strategies to eliminate them from the gastrointestinal tract of chickens.

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Section: Introductionmentioning

confidence: 99%

The interplay between Campylobacter and Helicobacter species and other gastrointestinal microbiota of commercial broiler chickens

Kaakoush

Sodhi

Chenu³

et al. 2014

Gut Pathog

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“…Indeed, several probiotics as well as food additives have been extensively studied under field conditions, but the results are highly variable, and strongly influenced by management, nutrition, environmental conditions, and obviously the levels of Salmonella challenge. Therefore, a general recommendation or a well-established protocol for probiotic or prebiotic prevention of Salmonella infection in farm animals is still unavailable (62, 63). …”

Section: Manipulation Of the Microbiota For Prophylactic And Therapeumentioning

confidence: 99%

Pathobiology of Salmonella, Intestinal Microbiota, and the Host Innate Immune Response

Santos

2014

Front. Immunol.

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Salmonella is a relevant pathogen under a clinical and public health perspective. Therefore, there has been a significant scientific effort to learn about pathogenic determinants of this pathogen. The clinical relevance of the disease, associated with the molecular tools available to study Salmonella as well as suitable animal models for salmonellosis, have provided optimal conditions to drive the scientific community to generate a large expansion of our knowledge about the pathogenesis of Salmonella-induced enterocolitis that took place during the past two decades. This research effort has also generated a wealth of information on the host immune mechanisms that complements gaps in the fundamental research in this area. This review focus on how the interaction between Salmonella, the microbiota and intestinal innate immunity leads to disease manifestation. As a highly successful enteropathogen, Salmonella actively elicits a robust acute intestinal inflammatory response from the host, which could theoretically lead to the pathogen demise. However, Salmonella has evolved redundant molecular machineries that renders this pathogen highly adapted to the inflamed intestinal environment, in which Salmonella is capable of outcompete resident commensal organisms. The adaptation of Salmonella to the inflamed intestinal lumen associated with the massive inflammatory response that leads to diarrhea, generate perfect conditions for transmission of the pathogen. These conditions illustrate the complexity of the co-evolution and ecology of the pathogen, commensals, and the host.

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“…Патогенные микроорганизмы вызывают нарушение состава кишечной микробиоты, изменения толщины, внешнего вида, мышечного тонуса, прочности и повышенной парацеллюлярной проницаемости стенок кишечника для токсических метаболитов, что в итоге негативно отражается на состоянии здоровья и продуктивности стада. Снижение риска развития инфекционных патологий у птиц широко связывают с формированием здоровой микробиоты пищеварительного тракта, которая способна обеспечить высокую резистентность к колонизации кишечника патогенами (Yeoman et al, 2012;Callaway et al, 2008;Kerr et al, 2013) благодаря синтезу ими летучих жирных кислот (ЛЖК), бактериоцинов и других, сдерживающих рост и развитие патогенных видов, соединений (Brisbin et al, 2011;Dobson et al, 2012;Messaoudi et al, 2012). До 90-х годов прошлого столетия исследования микроорганизмов в разных экосистемах были ограничены изучением культивируемых штаммов на искусственных питательных средах.…”

Section: Introductionunclassified

Изменение Микробиоты Кишечника Кур В Онтогенезе

Никонов¹,

Ильина²,

Kochish

et al. 2017

Ukr J Ecol

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This paper presents the results of a molecular genetic analysis of the changes in the composition of the microbiota of the blind processes of the intestine of the hens of the industrial loam "Lohmann Brown" during ontogeny. According to the results of the analysis of taxonomic affiliation it is established that over 70% of the phylotypes belong to the three phylums -Firmicutes, Bacteroidetes and Proteobacteria, less represented were Actinobacteria, Tenericutes and Fusobacteria, and a significant number of unidentified bacteria was detected. During ontogenesis, birds exhibited marked changes in the ratio of the number of phylotypes and taxonomic groups of the intestinal microbiota. At the age of 20-40 weeks, the birds showed a significant increase in the representatives of the Clostridia class involved in the metabolism of carbohydrates, acid-utilizing bacteria of the order Negativicutes and bacteria with high antagonistic properties (Bifidobacteriales, Bacillus), as well as a significant decrease in the content of a number of opportunistic and pathogenic taxa -family Enterobacteriaceae, the order of Pseudomonadales, phylum Tenericutes. The greatest homogeneity of the bacterial community of the blind processes of the gastrointestinal tract in laying hens was revealed at the age of 20 weeks, which is confirmed by the estimation of biodiversity by means of ecological indices. Keywords: bacterial community; microbiota; blind intestinal processes; chickens; Lohmann Brown cross; T-RFLP analysis Изменение микробиоты кишечника кур в онтогенезе

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A systematic review-meta-analysis and meta-regression on the effect of selected competitive exclusion products on Salmonella spp. prevalence and concentration in broiler chickens

Cited by 44 publications

References 39 publications

The interplay between Campylobacter and Helicobacter species and other gastrointestinal microbiota of commercial broiler chickens

The interplay between Campylobacter and Helicobacter species and other gastrointestinal microbiota of commercial broiler chickens

Pathobiology of Salmonella, Intestinal Microbiota, and the Host Innate Immune Response

Изменение Микробиоты Кишечника Кур В Онтогенезе

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