A systematic review and meta-analysis of the prevalence of Helicobacter pylori in patients with diabetes

Mansori, Kamyar; Dehghanbanadaki, Hojat; Naderpour, Sara; Rashti, Roya; Moghaddam, Ali Baradaran; Moradi, Yousef

doi:10.1016/j.dsx.2020.05.009

Cited by 21 publications

(18 citation statements)

References 32 publications

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“…Thenceforth, most of the studies have corroborated this finding reporting a higher prevalence of H. pylori in patients with Type 2 Diabetes (usually greater than 50%) in diabetic patients than in non-diabetic subjects (85)(86)(87)(88). Recently published meta-analyses this year aimed at elucidating the direction of the relationship between H. pylori and Type 2 Diabetes (81). Pooled H. pylori prevalence in diabetic patients was 54%, but there were high (even contradictory) regional variability as the highest prevalence of H. pylori infection in patients with T2DM was 66% in Africa and the lowest was 15% in USA (81).…”

Section: H Pylori Infection and Metabolic Diseasesmentioning

confidence: 87%

“…Associations between H. pylori infection and glucose homeostasis have been also explored (10,23,80,81). Evidence suggests that H. pylori may be involved in both diabetes onset and impaired glycemic control in diabetic patients, but contradictory trends or lack of association between H. pylori infection and type 2 Diabetes have been also reported (80,81). One of the mechanisms proposed for this relationship is the proinflammatory milieu induced by H. pylori infection that promotes gastric inflammation and cytokine secretion.…”

Section: H Pylori Infection and Metabolic Diseasesmentioning

confidence: 99%

“…Recently published meta-analyses this year aimed at elucidating the direction of the relationship between H. pylori and Type 2 Diabetes (81). Pooled H. pylori prevalence in diabetic patients was 54%, but there were high (even contradictory) regional variability as the highest prevalence of H. pylori infection in patients with T2DM was 66% in Africa and the lowest was 15% in USA (81). Moreover, it was found that patients with H. pylori infection had a higher risk of Type 2 Diabetes, but results again differed depending on geographical regions with a direct relationship in Europe, Asian and Africa, but a negative relationship in USA (80).…”

Section: H Pylori Infection and Metabolic Diseasesmentioning

confidence: 99%

“…In subgroup analysis, the relationship between H. pylori and the risk of diabetes was different according to age, level of glycated hemoglobin A (HbA1c), duration of diabetes and methods for H. pylori detection. This suggests that these factors could be an important source of heterogeneity in the studies included in the meta-analyses (80,81).…”

Section: H Pylori Infection and Metabolic Diseasesmentioning

confidence: 99%

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Gut Microbiota: The Missing Link Between Helicobacter pylori Infection and Metabolic Disorders?

et al. 2021

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Helicobacter pylori (H. pylori) is a gram-negative bacterium that infects approximately 4.4 billion individuals worldwide. Although the majority of infected individuals remain asymptomatic, this bacterium colonizes the gastric mucosa causing the development of various clinical conditions as peptic ulcers, chronic gastritis and gastric adenocarcinomas and mucosa-associated lymphoid tissue lymphomas, but complications are not limited to gastric ones. Extradigestive pathologies, including metabolic disturbances such as diabetes, obesity and nonalcoholic fatty liver disease, have also been associated with H. pylori infection. However, the underlying mechanisms connecting H. pylori with extragastric metabolic diseases needs to be clarified. Notably, the latest studies on the topic have confirmed that H. pylori infection modulates gut microbiota in humans. Damage in the gut bacterial community (dysbiosis) has been widely related to metabolic dysregulation by affecting adiposity, host energy balance, carbohydrate metabolism, and hormonal modulation, among others. Taking into account that Type 2 diabetic patients are more prone to be H. pylori positive, gut microbiota emerges as putative key factor responsible for this interaction. In this regard, the therapy of choice for H. pylori eradication, based on proton pump inhibitor combined with two or more antibiotics, also alters gut microbiota composition, but consequences on metabolic health of the patients has been scarcely explored. Recent studies from our group showed that, despite decreasing gut bacterial diversity, conventional H. pylori eradication therapy is related to positive changes in glucose and lipid profiles. The mechanistic insights explaining these effects should also be addressed in future research. This review will deal with the role of gut microbiota as the linking factor between H. pylori infection and metabolic diseases, and discussed the impact that gut bacterial modulation by H. pylori eradication treatment can also have in host’s metabolism. For this purpose, new evidence from the latest human studies published in more recent years will be analyzed.

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Section: H Pylori Infection and Metabolic Diseasesmentioning

confidence: 87%

Section: H Pylori Infection and Metabolic Diseasesmentioning

confidence: 99%

Section: H Pylori Infection and Metabolic Diseasesmentioning

confidence: 99%

Section: H Pylori Infection and Metabolic Diseasesmentioning

confidence: 99%

See 2 more Smart Citations

Gut Microbiota: The Missing Link Between Helicobacter pylori Infection and Metabolic Disorders?

et al. 2021

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“…On the other hand, patients with diabetes are also exposed to H. pylori because the humoral and cellular immune systems have been damaged and the person is susceptible to the bacterium. Decreased gastric motility in patients with diabetes reduces gastric acid and provides a basis for colonization of H. pylori strains [ 83 , 84 ]. Finally, it is concluded that cag + strains of H. pylori can predispose people to type II diabetes.…”

Section: Discussionmentioning

confidence: 99%

Association of Helicobacter pylori infection with the risk of metabolic syndrome and insulin resistance: an updated systematic review and meta-analysis

Azami

Baradaran

Dehghanbanadaki

et al. 2021

Diabetol Metab Syndr

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Background Conflicting results of recent studies on the association between Helicobacter pylori (H. pylori) infection and the risk of insulin resistance and metabolic syndrome explored the need for updated meta-analysis on this issue. Therefore, this systematic review aimed to estimate the pooled effect of H. pylori infection on the risk of insulin resistance and metabolic syndrome. Methods To identify case–control studies and cohort studies evaluating the association of H. pylori infection with insulin resistance and metabolic syndrome, a comprehensive literature search was performed from international databases including Medline (PubMed), Web of Sciences, Scopus, EMBASE, and CINHAL from January 1990 until January 2021. We used odds ratio with its 95% confidence interval to quantify the effect of case–control studies and risk ratio with its 95% CI for the effect of cohort studies. Results 22 studies with 206,911 participants were included for meta-analysis. The pooled estimate of odds ratio between H. pylori infection and metabolic syndrome in case–control studies was 1.19 (95% CI 1.05–1.35; I2 = 0%), and in cohort studies, the pooled risk ratio was 1.31 (95% CI 1.13–1.51; I2 = 0%). Besides, case–control studies showed the pooled odds ratio of 1.54 (95% CI 1.19–1.98; I2 = 6.88%) for the association between H. pylori infection and insulin resistance. Conclusion In this meta-analysis, the results showed that there was a possibility of metabolic syndrome and insulin resistance in case of H. pylori infection.

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Is Diabetes Mellitus a Predisposing Factor for Helicobacter pylori Infections?

et al. 2023

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A systematic review and meta-analysis of the prevalence of Helicobacter pylori in patients with diabetes

Cited by 21 publications

References 32 publications

Gut Microbiota: The Missing Link Between Helicobacter pylori Infection and Metabolic Disorders?

Gut Microbiota: The Missing Link Between Helicobacter pylori Infection and Metabolic Disorders?

Association of Helicobacter pylori infection with the risk of metabolic syndrome and insulin resistance: an updated systematic review and meta-analysis

Is Diabetes Mellitus a Predisposing Factor for Helicobacter pylori Infections?

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