Is Diabetes Mellitus a Predisposing Factor for Helicobacter pylori Infections?

Sahoo, Om Saswat; Mitra, Robi D.; Bhattacharjee, Arghyadeep; Kar, Samarjit; Mukherjee, Oindrilla

doi:10.1007/s11892-023-01511-5

Cited by 7 publications

(2 citation statements)

References 93 publications

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“… 34 One of the key factors that make diabetic patients more susceptible to H. pylori infections is delayed gastric emptying. 35 , 36 Inflammation and immune responses in diabetic patients can impact the metabolism of peripheral nerves, leading to antrum pyloric motor incoordination and delayed gastric emptying, and in some cases, even gastroparesis caused by gastrointestinal motor neuropathy. 35 , 36 These conditions weaken the ability of the gastric wall to resist various invasions, making it easier for H. pylori to settle and significantly increasing the infection rate of H. pylori in diabetic patients with gastroparesis.…”

Section: Discussionmentioning

confidence: 99%

Recurrence Rate and Influencing Factors of Helicobacter Pylori Infection After Successful Eradication in Southern Coastal China

Zhang,

Mao,

Huang

et al. 2024

IJGM

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Purpose Recurrence rate of Helicobacter pylori ( H. pylori ) infection after successful eradication have gained attention. This study was to assess the recurrence rate of H. pylori infection after successful eradication in the southern coastal provinces of China and to analyze its factors. Patients and Methods 975 patients with upper gastrointestinal symptoms who were diagnosed with H. pylori infection using the 13C or 14C-urea breath test (UBT) underwent eradication treatment between August 2021 and December 2022. After eight to twelve weeks, repeat UBT was performed. Besides, 824 patients with successful eradication underwent a repeat UBT by completing questionnaires after a year. The 1-year recurrence rate was calculated, and the differences were analyzed based on baseline data, sociological characteristics, and lifestyle. Results A total of 734 patients completed the 1-year follow-up, out of which 26 (3.5%) patients experienced a recurrence of H. pylori infection. Exposure to other individuals infected with H. pylori ( χ 2 =12.852, P <0.001), poor hygiene conditions at dining out places ( χ 2 =6.839, P =0.009), frequent dining out ( χ 2 =24.315, P <0.001), smoking ( χ 2 =7.510, P =0.006), consumption of non-purified water ( χ 2 =16.437, P <0.001), consumption of pickled foods ( χ 2 =5.682, P =0.017), irregular meal patterns ( χ 2 =16.877, P <0.001) and age ( χ 2 =9.195, P=0.010) were significant factors for H. pylori infection recurrence. Exposure to other individuals infected with H. pylori , poor hygiene conditions at dining out places, consumption of non-purified water, frequent dining out and irregular meal patterns were independent risk factors ( P =0.022, 0.016, 0.002, <0.001, <0.001; 95% CI 0.146–0.861, 0.121–0.806, 1.715–10.845, 0.085–0.521, 2.291–14.556). Conclusion The one-year recurrence rate of H. pylori infection post-eradication in the southern coastal provinces of China is 3.5%. Contacting with infected individuals, poor hygiene in dining places, consumption of non-purified water, frequent dining out, and irregular meal patterns were identified as significant independent factors influencing H. pylori recurrence....

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Section: Discussionmentioning

confidence: 99%

Recurrence Rate and Influencing Factors of Helicobacter Pylori Infection After Successful Eradication in Southern Coastal China

Zhang,

Mao,

Huang

et al. 2024

IJGM

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“…While it was long thought that tumors are sterile, researchers have demonstrated the presence of microbiome in the tumoral milieu; this includes H. pylori DNA, which was found in 60% of patients with PC, suggesting that H. pylori may play a role in the occurrence of PC [19]. However, there are also data showing a higher prevalence of H. pylori infection in diabetic obese patients compared to nondiabetic patients (23.6% vs. 11.8%, p < 0.001) [20], suggesting that T2DM is a predisposing factor for the infection [21] and that the bacterium may be able to play its pathogenic role in the whole disease process [22].…”

Section: The Importance Of Microbiome In Pancreatic Cancer and Diabet...mentioning

confidence: 99%

Could Microbiome Be the Common Co-Denominator between Type 2 Diabetes and Pancreatic Cancer?

Golčić,

Belančić

2023

Diabetology

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Similar microorganisms, via similar mechanisms, play a role in the development of both pancreatic cancer (PC) and type 2 diabetes (T2D). Since the new onset of T2D is potentially one of the earliest signs of PC, it is highly plausible that a common denominator might be responsible for both, as the growth of the cancer will take a longer time to manifest compared to the insulin resistance. Although a variety of host-dependent factors and susceptibility play a role, and the mechanisms connecting the two diseases remain poorly understood, future well-designed trials should hypothesize whether a microbial intervention (modification and/or transplantation) results in a lower incidence and the better treatment of both diseases since the T2D–PC–gut microbiome interconnection seems scientifically logical.

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Infiltration to infection: key virulence players of Helicobacter pylori pathogenicity

Bhattacharjee,

Sahoo,

Sarkar

et al. 2024

Infection

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Is Diabetes Mellitus a Predisposing Factor for Helicobacter pylori Infections?

Cited by 7 publications

References 93 publications

Recurrence Rate and Influencing Factors of Helicobacter Pylori Infection After Successful Eradication in Southern Coastal China

Recurrence Rate and Influencing Factors of Helicobacter Pylori Infection After Successful Eradication in Southern Coastal China

Could Microbiome Be the Common Co-Denominator between Type 2 Diabetes and Pancreatic Cancer?

Infiltration to infection: key virulence players of Helicobacter pylori pathogenicity

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