A Systematic Review and Meta-analysis of Intralesional Versus Wide Resection for Intramedullary Grade I Chondrosarcoma of the Extremities

Abstract

Intralesional curettage as an alternative to wide resection for extrapelvic grade I chondrosarcoma of bone does not greatly increase the risk for local recurrence or metastasis. Overall effect estimates, however, should be interpreted with caution as a result of the relatively small number of events.

Preoperative radiographic and histopathologic evaluation of central chondrosarcoma

“…However, distinguishing grade 1 chondrosarcoma from grade 2 chondrosarcoma is clinically among the most important aspects of diagnosis, both for planning the surgical procedure and for predicting the outcome because (1) grade 1 lesions almost never metastasize [9, 25], but grade 2 or 3 lesions tend to recur and form metastases, and (2) intralesional treatment may be adequate for grade 1 chondrosarcoma in contrast to grade 2 or 3 lesions, which may require wide resection [2–8]. We also discuss grade evaluation of several cases of chondrosarcoma at a tumor board meeting before surgery.…”

“…Recently, some authors advocated the adequacy of intralesional surgery for grade 1 chondrosarcoma [2–8]. However, this tumor remains a challenge to diagnose accurately and treat effectively.…”

Intralesional curettage of central low-grade chondrosarcoma: A midterm follow-up study

“…However, some studies suggested that axial lesion of central low-grade chondrosarcoma was an adverse factor for local recurrence after curettage. 19,20 In our experience, axial lesions are difficult to approach on anatomy, and the local adjuvant treatment may be difficult to achieve. We agreed that long bone was good indication for extended intralesional curettage with adjuvant local treatment.…”

“…8e10 Some others reported that intralesional curettage wound not increase the recurrence rates. 12,17,19,20 The discrepancy of the results may be related to the extent of the curettage. The overall recurrence rate of low-grade chondrosarcoma after treatment in our study was 9.1%, and the respective recurrence rate was 14.3% in the Group A.…”

Tracheal Chondrosarcoma: Systematic Review of Tumor Characteristics, Diagnosis, and Treatment Outcomes with Case Report

“…Recent studies of low-grade chondrosarcomas in the extremities have found that aggressive intralesional curettage, with or without cryosurgery at the margin, may be an acceptable alternative to wide excision of these lesions [36, 37]. These initial studies demonstrate that recurrence rates after aggressive intralesional excision are relatively low and that they do not differ, significantly, from those of wide excision (3.8% recurred in intralesional excision and 1.8% recurred in wide excision).…”