A systematic review and meta-analysis of the prebiotics and synbiotics effects on glycaemia, insulin concentrations and lipid parameters in adult patients with overweight or obesity

Beserra, Bruna Teles Soares; Fernandes, Ricardo; Rosario, Vinicius A. do; Mocellin, Michel Carlos; Kuntz, Marilyn Gonçalves Ferreira; Trindade, Erasmo B. S. M.

doi:10.1016/j.clnu.2014.10.004

Cited by 150 publications

(94 citation statements)

References 29 publications

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“…In accordance with the present results, Mokhtari et al (2015) established that significantly reduced abdominal fat was observed with broiler diets, depending on the addition of Syn. According to Beserra et al (2015), the administration of Syn is efficient in improving lipid profiles. Studies on quails have found that female quails had higher rates of heart, liver, and stomach than male quails, which is consistent with the current study (Alkan et al, 2013;Ojedapo and Amao, 2014).…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary addition of synbiotic on the performance, carcass traits, and serum parameters of Japanese quails

Tufan

Bolacali

2017

R. Bras. Zootec.

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-This study aimed to evaluate the effects of different levels of synbiotic (Syn) on the growth performance, carcass traits, and serum parameters of Japanese quails. A total of 1,500 (750 male and 750 female) Japanese quails were assigned to five treatments, including the control (basal diet) and basal diets with the addition of 0.1, 0.2, 0.3, and 0.4% Syn according to a completely randomized design. Each treatment in the male and female experiment groups consisted of five replicates, with 30 chicks for each replicate. The addition of Syn had no effect on body weight (BW), while the BW of female quails was higher than that of male quails at day 42. The addition of Syn reduced feed intake (FI) and improved the feed conversion ratio (FCR) (P<0.000). The daily body weight gain and FI were significantly higher in female than in male quails and Syn also improved the FCR in the overall experiment. The effect of the addition of Syn on carcass parameters (except for abdominal fat) was not determined. The addition of Syn decreased abdominal fat weight and percentage when compared with the control group. Male quails were found to have higher carcass yield, wing, neck, and other percentages than female quails. However, female quails were found to have higher breast, breast skin, abdominal fat, and visceral organ percentages. The addition of 0.1% Syn to quail ration reduced serum aspartate aminotransferase, high-density lipoprotein (HDL), total protien (TP), and albumin (ALB) levels at day 42 of the trial. The addition of Syn decreased the serum total cholesterol level. Gender was found to have an effect in that female quails were found to have higher total cholesterol, HDL, TP, and ALB levels than male quails. In both genders, the addition of Syn improved the BWG, FC, and FCR in the overall experiment, reduced abdominal fat, decreased the total cholesterol levels, improved the HDL levels, and increased the TP and ALB levels at day 42. The addition of 0.3 and/or 0.4% synbiotic has a positive effect on quails by improving performance and enhancing some serum lipids and protein parameters.

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Section: Discussionmentioning

confidence: 99%

Effects of dietary addition of synbiotic on the performance, carcass traits, and serum parameters of Japanese quails

Tufan

Bolacali

2017

R. Bras. Zootec.

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“…It is likely that these alterations play a role in the accumulation of LDL-cholesterol and disease pathogenesis. The accumulation of plasma cholesterol can also be moderated by diet, while pharmaceutical and pre-and probiotic administration have largely been associated with reduced LDLcholesterol levels and CVD risk (9)(10)(11)(12)(13) .…”

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confidence: 99%

Investigating cholesterol metabolism and ageing using a systems biology approach

et al. 2016

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CVD accounted for 27 % of all deaths in the UK in 2014, and was responsible for 1·7 million hospital admissions in 2013/2014. This condition becomes increasingly prevalent with age, affecting 34·1 and 29·8 % of males and females over 75 years of age respectively in 2011. The dysregulation of cholesterol metabolism with age, often observed as a rise in LDL-cholesterol, has been associated with the pathogenesis of CVD. To compound this problem, it is estimated by 2050, 22 % of the world's population will be over 60 years of age, in culmination with a growing resistance and intolerance to pre-existing cholesterol regulating drugs such as statins. Therefore, it is apparent research into additional therapies for hypercholesterolaemia and CVD prevention is a growing necessity. However, it is also imperative to recognise this complex biological system cannot be studied using a reductionist approach; rather its biological uniqueness necessitates a more integrated methodology, such as that offered by systems biology. In this review, we firstly discuss cholesterol metabolism and how it is affected by diet and the ageing process. Next, we describe therapeutic strategies for hypercholesterolaemia, and finally how the systems biology paradigm can be utilised to investigate how ageing interacts with complex systems such as cholesterol metabolism. We conclude by emphasising the need for nutritionists to work in parallel with the systems biology community, to develop novel approaches to studying cholesterol metabolism and its interaction with ageing.

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“…Supplementation with fermented noni juice, as in the study by Lin et al (2005), may have beneficial effects of noni or prebiotics resulting from fermentation, which may contribute to the improvement of the lipid profile (Beserra et al, 2015). As for the study by Mandukhail et al (2010), the benefits found were for the pulp, the leaves, and the aqueous extract of the fruit.…”

Section: Discussionmentioning

confidence: 56%

Effects of Consumption of Noni (Morinda citrifolia) in Rats Fed a High-Fat Diet

Machado¹,

Sousa²,

Montenegro³

et al. 2016

IJMP

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Objective: To evaluate the effects of noni consumption on risk factors for cardiovascular disease, fasting glucose and hepatic and renal function in rats fed a high-fat diet. Methods: 18 Wistar rats were divided into three groups. Group control (C) was fed with high-fat diet and water. Group's noni juice (NJ) and noni infusion (NI) received the same diet and noni juice and infusion, respectively, for 4 weeks. After this time were assessed anthropometric measurements, adiposity, organ weights and biochemical measurements. Results: Groups NJ and NI had higher waist circumference compared to group C (C=11.0 cm, NJ=12.8 cm and NI=14.0 cm, p<0.05), lower serum creatinine (C=0.8 mg/dL, NJ=0.2 mg/dL and NI=0.3 mg/dL, p<0.05), and higher blood urea nitrogen/creatinine ratio (C=92.7, NJ=349.3 and NI=230.4, p<0.05). Noni infusion consumption promoted higher serum total cholesterol (C=59.7 mg/dL, NJ=60.1 mg/dL and NI=99.8 mg/dL, p<0.05) and LDL (C=48.5 mg/dL, NJ=42.0 mg/dL and NI=78.7 mg/dL, p<0.05). Conclusion: Consumption of noni, either as juice or as infusion, promoted higher waist circumference and blood urea nitrogen/creatinine ratio. Furthermore, noni infusion consumption promoted increased of serum total cholesterol and LDL

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A systematic review and meta-analysis of the prebiotics and synbiotics effects on glycaemia, insulin concentrations and lipid parameters in adult patients with overweight or obesity

Cited by 150 publications

References 29 publications

Effects of dietary addition of synbiotic on the performance, carcass traits, and serum parameters of Japanese quails

Effects of dietary addition of synbiotic on the performance, carcass traits, and serum parameters of Japanese quails

Investigating cholesterol metabolism and ageing using a systems biology approach

Effects of Consumption of Noni (Morinda citrifolia) in Rats Fed a High-Fat Diet

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