A systematic review and meta-analysis of exercise interventions in adults with type 1 diabetes

Yardley, Jane E.; Hay, Jacqueline; Abou‐Setta, Ahmed M; Marks, Seth D.; McGavock, Jonathan

doi:10.1016/j.diabres.2014.09.038

Cited by 120 publications

(85 citation statements)

References 28 publications

(56 reference statements)

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“…The majority of research investigating the impact of exercise in persons with type 1 diabetes is limited to exercise durations for up to 2 hours per session [22,23]. As such, most information on glycemic control during and after prolonged physical activity (>2 h) can be considered as 'anecdotal evidence'.…”

Section: Discussionmentioning

confidence: 99%

Glycemic control during consecutive days with prolonged walking exercise in individuals with type 1 diabetes mellitus

Dijk

Eijsvogels

Nyakayiru

et al. 2016

Diabetes Research and Clinical Practice

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Running title: prolonged physical activity in type 1 diabetes Word count abstract: 239Word count main text: 3182 Tables: 1 Figures: 4 Trial number: NTR4061, www.trialregister.nl ABSTRACT Aims: Despite its general benefits for health, exercise complicates the maintenance of stable blood glucose concentrations in individuals with type 1 diabetes. The aim of the current study was to examine changes in food intake, insulin administration, and 24-h glycemic control in response to consecutive days with prolonged walking exercise (~8 h daily) in individuals with type 1 diabetes. Methods:Ten individuals with type 1 diabetes participating in the worlds' largest walking event were recruited for this observational study. Simultaneous measurements of 24-h glycemic control (continuous glucose monitoring), insulin administration and food intake were performed during a non-walking day (control) and during three subsequent days with prolonged walking exercise (daily distance 40 or 50 km). Results:Despite an increase in daily energy (31±18%; p<0.01) and carbohydrate (82±71g; p<0.01) intake during walking days, subjects lowered their insulin administration by 26±16% relative to the control day (p<0.01). Average 24-h blood glucose concentrations, the prevalence of hyperglycemia (blood glucose >10 mmol/L) and hypoglycemia (blood glucose <3.9 mmol/L) did not differ between the control day and walking days (p>0.05 for all variables). The prolonged walking exercise was associated with a modest increase in glycemic variability compared with the control day (p<0.05). Conclusion:Prolonged walking exercise allows for profound reductions in daily insulin administration in persons with type 1 diabetes, despite large increments in energy and carbohydrate intake. When taking such adjustments into account, prolonged moderate-intensity exercise does not necessarily impair 24-h glycemic control.

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Section: Discussionmentioning

confidence: 99%

Glycemic control during consecutive days with prolonged walking exercise in individuals with type 1 diabetes mellitus

Dijk

Eijsvogels

Nyakayiru

et al. 2016

Diabetes Research and Clinical Practice

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“…Current literature is inconsistent whether exercise has a meaningful effect on HbA1c [6][7][8]. Beraki et al (2014) reported lower HbA1c levels in active persons with diabetes than in sedentary ones in a large cohort [6].…”

Section: Discussionmentioning

confidence: 99%

“…Beraki et al (2014) reported lower HbA1c levels in active persons with diabetes than in sedentary ones in a large cohort [6]. Additionally, two recent meta-analyses found different results of whether exercise improves glucose control or not [7,8]. Yardley et al (2014) found a significant reduction in post-treatment HbA1c in four out of six studies but there was also one trial which showed no decrease at all [8].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, two recent meta-analyses found different results of whether exercise improves glucose control or not [7,8]. Yardley et al (2014) found a significant reduction in post-treatment HbA1c in four out of six studies but there was also one trial which showed no decrease at all [8]. Another even larger meta-analysis could not find evidence for a glycaemic benefit of exercise when followed by HbA1c [7], thus the issue remains unsolved.…”

Section: Discussionmentioning

confidence: 99%

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Physical activity does not inevitably improve quality of life in young adults with type 1 diabetes

Häyrinen

Tarkka

2016

Diabetes Research and Clinical Practice

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“…Clinical practice guidelines recommend 150 min of moderate (50-70% of person's maximum heart rate) to vigorous (>70% of person's maximum heart rate) physical activity weekly for adults with T1D 6 . However, more than 60% of adults with T1D do not achieve recommended levels of physical activity 7 .…”

Section: Introductionmentioning

confidence: 99%

Interval Training Is Insufficient to Attenuate Metabolic Disturbances in Diabetic Rats

Rocha

Nunes

Venera

et al. 2016

Rev Bras Med Esporte

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Introduction: Type 1 diabetes is a metabolic disease associated to blood disturbances and disorder of the innate immune system functionality. Objective: This study investigated the effect of two weeks interval training on blood biochemistry and immunological parameters in rats with type 1 diabetes. Methods: Male Wistar rats were divided into three groups: sedentary (SE, n = 10), diabetic sedentary (DI, n = 10), diabetic interval training (DIT, n = 10). IV injection of streptozotocin (45 mg/kg) induced diabetes. Interval training consisted of swimming exercise for 30 seconds with 30 seconds of rest for 30 minutes three times a week during two weeks, with an overload of 15% of the total body mass. The evaluations performed were fasting blood glucose, triglycerides, very low-density lipoprotein cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and total cholesterol concentrations, phagocytic capacity, cationic vesicles content, superoxide anion, and production of hydrogen peroxide of blood neutrophils and peritoneal macrophages. Results: The results showed that two weeks interval training did not attenuate the hyperglycemic state at rest and did not decrease blood lipids in the DIT group. Diabetes increased the functionality of blood neutrophils and peritoneal macrophages in the DI group. Interval training increased the content of cationic vesicles and the phagocytic capacity of blood neutrophils and peritoneal macrophages in the DIT group. Conclusion: It was found that two weeks of interval training increased the functionality parameters of innate immune cells, although this has been insufficient to attenuate the biochemical disorders caused by diabetes.

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A systematic review and meta-analysis of exercise interventions in adults with type 1 diabetes

Cited by 120 publications

References 28 publications

Glycemic control during consecutive days with prolonged walking exercise in individuals with type 1 diabetes mellitus

Glycemic control during consecutive days with prolonged walking exercise in individuals with type 1 diabetes mellitus

Physical activity does not inevitably improve quality of life in young adults with type 1 diabetes

Interval Training Is Insufficient to Attenuate Metabolic Disturbances in Diabetic Rats

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