A Systematic Review and Meta-Analysis of Oncologic Outcomes of Pre- Versus Postoperative Radiation in Localized Resectable Soft-Tissue Sarcoma

Abstract

The delay in surgical resection necessary to complete preoperative radiation does not seem to increase the risk of lethal metastatic spread. The risk of local recurrence may be lower after preoperative radiation. These findings must be interpreted with caution because of the heterogeneity and bias in the available studies.

Systematic Review and Meta-Analysis of Case-Matched Studies Comparing Open and Laparoscopic Distal Pancreatectomy

“…29 In our case, quality assessment was performed using the NOS, which is purposely designed to evaluate through the use of a checklist the quality of observational studies. However, although the NOS is used in practice, 30 it was not surprising that it was more suitable for use in observational studies of an epidemiological nature rather than nonrandomized interventional studies in a surgical setting.…”

Surgical treatment and prognosis in patients with high-grade soft tissue malignant fibrous histiocytoma of the extremities

“…MFH is considered as a tumor with higher potential to recur locally [24]. It is well accepted that positive histological margins are associated with increased rate of LR [8,17,18,25].…”

A Meta-Analysis of the Association Between Radiation Therapy and Survival for Surgically Resected Soft-Tissue Sarcoma

“…The results from this study showed that average survival was 76% (range, 62% to 88%) in the preoperative group and 67% (range, 41% to 83%) in the postoperative group, and no significant difference between the 2 groups. 44 Limitations of our study should be acknowledged. We were not able to incorporate patient-level data in our metaanalysis and the results are from study-level data.…”