A systematic review and meta-analysis of guided tissue regeneration/osseous grafting for the treatment of Class II furcation defects

Chen, Tsung Hung; Tu, Yu–Kang; Yen, Chia Chen; Lu, Hsueh-I

doi:10.1016/j.jds.2013.06.006

Cited by 18 publications

(18 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results are in accordance to the results of a meta-analysis of 10 studies that showed statistically signi icant greater vertical and horizontal bone ill for GTR + Osseous graft(OG) with OFD in furcation defects (Chen et al, 2013;Mcclain and Schallhorn, 1993b). It is also in accordance to a study where bone volume in the Silk Fibroin group at 4 weeks were greater than in the Bio-Gide group in Sprague-Dawley rats (Lu et al, 2015;Seok et al, 2014) who showed that New Zealand white rabbits when treated with silk membranes of 0.5mm thickness, resulting in effective bone regeneration.…”

Section: Radiographic Parameterssupporting

confidence: 88%

Development of biodegradable silkworm cocoon derived silk membrane for GTR in the treatment of grade II furcation

Sankar¹,

Gujjari²,

Pk³

et al. 2020

ijrps

View full text Add to dashboard Cite

This was a preliminary study to develop a biodegradable membrane from silkworm Bombyx.mori. The silk ibroin membrane prepared was analyzed for tensile strength and used in patients with grade II furcation defects, which was compared with collagen membrane. Though collagen is the gold standard, it has disadvantages, one of them being slow biodegradability. Hence this research was carried out to see if silk ibroin was good as a regenerative material in providing bone ill in the furcal area. As it is commonly accepted that treatment in the furcal area is better with bone graft and GTR membrane compared with just bone graft and lap surgery, this clinical trial with a common bone graft was carried out in addition to barrier membrane, which were of different sources. The patients ful illing the inclusion criteria were randomized into test and control sites. The test sites received bone graft(colocast) and silk ibroin membrane while the control site received bone graft(colocast) and collagen membrane(cologide). The bone ill was analyzed radiographically using AUTOCAD software 2017. The results of the study showed that both the sites did not show any adverse effects, but improvement were noted clinically and radiographically. Radiographically signi icant improvement was seen in silk ibroin sites indicating that silk ibroin with bone graft would be better as a regenerative material.

show abstract

Section: Radiographic Parameterssupporting

confidence: 88%

Development of biodegradable silkworm cocoon derived silk membrane for GTR in the treatment of grade II furcation

Sankar¹,

Gujjari²,

Pk³

et al. 2020

ijrps

View full text Add to dashboard Cite

show abstract

“…Thirty‐four articles were excluded after full‐text review (Table 3). 10‐12,16,30‐59 A final selection of 150 articles was made, of which six were systematic reviews, 2,60‐64 109 were clinical trials, 53,65‐172 27 were case series, 173‐199 and eight were case reports 200‐207 . No cohort studies were identified.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 24 clinical trials 149‐172 and 13 case series 185‐197 were non‐classifiable, as defined in Materials and Methods (Tables 4 and 5). Of the 85 remaining clinical trials, 53,65‐148 eight reported outcomes after applying regenerative therapy on maxillary facial/interproximal Class II furcation defects, 76,87,92,100,105,140,148,208 68 on mandibular facial/lingual Class II furcation defects, 65‐68,70‐72,75,77,78,80‐85,87‐90,93‐99,101‐104,106,107,110‐112,114‐122,124‐139,141‐147 one on maxillary Class III furcation defects, 91 nine on mandibular Class III furcation defects, 69,73,74,77,86,108,109,113,123 and one on maxillary premolars presenting Class I and Class II furcation defects 79 . Of the 14 selected case series, two reported on the treatment of maxillary facial/interproximal Class II furcation defects, 177,180 11 on mandibular facial/lingual Class II furcation defects, 173‐176,178‐184 and two on mandibular Class III furcation defects 198,199 .…”

Section: Resultsmentioning

confidence: 99%

“…In 2013, Chen et al 64 published a systematic review aimed at assessing the evidence on the efficacy of GTR with or without osseous grafting for the treatment of Class II furcation defects. A total of 20 studies were selected, of which 13 studies were randomized clinical trials (RCTs) comparing OFD with GTR, four studies were RCTs comparing OFD with GTR plus bone graft, and six studies were RCTs comparing GTR with GTR plus bone graft.…”

Section: Resultsmentioning

confidence: 99%

“…Finally, GTR using an absorbable membrane was slightly superior to GTR using a non-absorbable membrane in terms of VPD reduction (0.25 mm), VAL gain (0.39 mm), horizontal defect fill (0.29 mm), and vertical defect fill (0.33 mm), although these differences were not significant. In 2013, Chen et al 64 published a systematic review aimed at assessing the evidence on the efficacy of GTR with or without osseous grafting for the treatment of Class II furcation defects. A total of 20 studies were selected, of which 13 studies were randomized clinical trials (RCTs) comparing OFD with GTR, four studies were RCTs comparing OFD with GTR plus bone graft, and six studies were RCTs comparing GTR with GTR plus bone graft.…”

Section: Non-classifiable Clinical Trials On the Effect Of Regeneratimentioning

confidence: 99%

See 2 more Smart Citations

Periodontal Regeneration – Furcation Defects: A Systematic Review From the AAP Regeneration Workshop

Ávila‐Ortiz

Buitrago

Reddy

2015

Journal of Periodontology

View full text Add to dashboard Cite

Background: The aim of this review is to present the available evidence regarding the effectiveness of different regenerative approaches for the treatment of furcation defects in specific clinical scenarios compared with conventional surgical therapy to provide clinical guidelines for the therapeutic management of furcation defects and to identify priorities for future research that may advance the understanding of periodontal regenerative medicine.Methods: A comprehensive search based on predetermined eligibility criteria was conducted to identify human original studies and systematic reviews on the topic of periodontal regeneration of furcation defects. Two reviewers independently screened the title and abstract of the entries yielded from the initial search. Subsequently, both reviewers read the full-text version of potentially eligible studies, made a final article selection, and extracted the data of the selected studies considering specific clinical scenarios. The clinical scenarios contemplated in this review included the following: 1) facial and interproximal Class I defects in maxillary molars; 2) facial and lingual Class I defects in mandibular molars; 3) facial and interproximal Class II furcation defects in maxillary molars; 4) facial and lingual Class II furcation defects in mandibular molars; 5) Class III furcation defects in maxillary molars; 6) Class III furcation defects in mandibular molars; and 7) Class I, II, or III furcation defects in maxillary premolars. Endpoints of interest included different clinical, radiographic, microbiologic, histologic, and patient-reported outcomes.Results: The initial search yielded a total of 1,500 entries. The final selection consisted of 150 articles, of which six were systematic reviews, 109 were clinical trials, 27 were case series, and eight were case reports. A summary of the main findings of previously published systematic reviews and the available evidence relative to the indication of regenerative approaches for the treatment of furcation defects compared with conventional surgical therapy are presented. Given the marked methodologic heterogeneity and the wide variety of materials and techniques applied in the selected clinical trials, the conduction of a meta-analysis was not viable.Conclusions: On the basis of the reviewed evidence, the following conclusions can be drawn. 1) Periodontal regeneration has been demonstrated histologically and clinically for the treatment of maxillary facial or interproximal and mandibular facial or lingual Class II furcation defects. 2) Although periodontal regeneration has been demonstrated histologically for the treatment of mandibular Class III defects, the evidence is limited to one case report. 3) Evidence supporting regenerative therapy in maxillary Class III furcation defects in maxillary molars is limited to clinical case reports. 4) In Class I furcation defects, regenerative therapy may be beneficial in certain clinical scenarios, although most Class I furcation defects may be successfully treated with non-regen...

show abstract

Regenerative Therapy of Furcations in Human Clinical Studies

Jepsen

2018

Diagnosis and Treatment of Furcation‐Involved Teeth

View full text Add to dashboard Cite

A systematic review and meta-analysis of guided tissue regeneration/osseous grafting for the treatment of Class II furcation defects

Cited by 18 publications

References 68 publications

Development of biodegradable silkworm cocoon derived silk membrane for GTR in the treatment of grade II furcation

Development of biodegradable silkworm cocoon derived silk membrane for GTR in the treatment of grade II furcation

Periodontal Regeneration – Furcation Defects: A Systematic Review From the AAP Regeneration Workshop

Regenerative Therapy of Furcations in Human Clinical Studies

Contact Info

Product

Resources

About