This was a preliminary study to develop a biodegradable membrane from silkworm Bombyx.mori. The silk ibroin membrane prepared was analyzed for tensile strength and used in patients with grade II furcation defects, which was compared with collagen membrane. Though collagen is the gold standard, it has disadvantages, one of them being slow biodegradability. Hence this research was carried out to see if silk ibroin was good as a regenerative material in providing bone ill in the furcal area. As it is commonly accepted that treatment in the furcal area is better with bone graft and GTR membrane compared with just bone graft and lap surgery, this clinical trial with a common bone graft was carried out in addition to barrier membrane, which were of different sources. The patients ful illing the inclusion criteria were randomized into test and control sites. The test sites received bone graft(colocast) and silk ibroin membrane while the control site received bone graft(colocast) and collagen membrane(cologide). The bone ill was analyzed radiographically using AUTOCAD software 2017. The results of the study showed that both the sites did not show any adverse effects, but improvement were noted clinically and radiographically. Radiographically signi icant improvement was seen in silk ibroin sites indicating that silk ibroin with bone graft would be better as a regenerative material.
The present study was undertaken to clinically assess the synergistic effect of topically applied Aloe vera Chitosan to Chitosan alone on the healing of palatal donor sites in free gingival graft surgical procedures. 20 subjects (10 per group) were enrolled into this triple blinded randomized clinical trial, designed to evaluate the efficacy of Aloe vera Chitosan to Chitosan on free gingival graft surgical wounds. Subjects were assigned to either Group A (aloe vera + Chitosan) or Group B (Chitosan alone). Visual Analog Scale(VAS) and Wound healing index were recorded at 7th day, 14th day and 21 days postoperative. Results showed no statistical significance when considering VAS. However there was a statistical significance in wound healing (p=0.04) in group A when compared to group B from 14- 21st day postoperative. It is the first human trial and was a pilot study to assess the synergistic effect of Aloe vera and Chitosan on wound healing. The study has shown that a combination of both acts synergistically in accelerating healing especially in areas where faster healing is necessary to provide overall comfort to the patient. It is therefore a futuristic and a promising material as a surgical dressing with further longitudinal trials.
Artificial planar bilayer phospholipid membrane was formed in KCl bath solutions and its electrical properties have been analyzed using electrochemical impedance spectroscopy. The stability of planar bilayer lipid membrane depends on concentration of KCl in the bath. Changes in the electrical properties of planar bilayer lipid membrane with the addition of lorazepam were also studied using electrochemical impedance spectroscopy. Lorazepam gets partitioned into bilayer lipid membrane and exhibited a fluidization effect. The ionic conductance across the bilayer lipid membrane increased with the addition of lorazepam to the bath. An impedimetric sensor was developed for quantification of lorazepam in solution.
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