A systematic review and meta-analysis of randomized controlled trials to evaluating the trend of cytokines to vitamin A supplementation in autoimmune diseases

Harirchian, Mohammad Hossein; Mohammadpour, Zinat; Fatehi, Farzad; Firoozeh, Negar; Bitarafan, Sama

doi:10.1016/j.clnu.2018.10.026

Cited by 7 publications

(1 citation statement)

References 37 publications

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“…Another study, also at the molecular level (a systematic review), involving the supplementation of patients with autoimmune diseases (MS and atherosclerosis), all with applications of 25,000 IU/d of retinyl palmitate, presented as the main hypothesis that the 25,000 IU/d dosage of retinyl palmitate for 3 to 6 months may increase serum retinoic acid (RA) levels in patients and significantly increase the expression of the RA receptor gene, thus suggesting that vitamin A supplementation can improve the level of serum cytokines and the clinical signs of autoimmune disease. [29]…”

Section: Discussionmentioning

confidence: 99%

Nutritional supplementation of vitamin A and health-related outcomes in patients with multiple sclerosis

Nunes

Piuvezam²

2019

Medicine

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Background: Multiple sclerosis (MS) is a chronic immune mediated disease which affects the central nervous system (CNS), having a substantial financial, functional, and quality of life (QOL) impact on these people. The vitamin A supplementation has been studied as a therapeutic possibility for in MS. Therefore, the objective of this protocol is to build an outline for a future systematic review, which will provide up-to-date available evidence about the clinical impact of nutritional supplementation of vitamin A in the outcomes related to the symptoms in patients with this pathology. Methods: The search will be performed in the following databases: PubMed, Embase, Scopus, cinahl, Scielo, Web of Science, the Cochrane Library and Science Direct, randomized clinical trials published until May 2019 that evaluate the relationship of the supplementation of vitamin A and health-related outcomes in patients with MS will be included. Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) will be used to outline the protocol, and PRISMA to the systematic review. Undergraduate handbook of quality of evidence and strength of recommendations for decision making in health (GRADE) will be used to assess the quality of evidence and the strength of the recommendation, and the JADAD scale to assess the internal validity of selected studies. For the extraction of all the data found a database in Microsoft Excel will be created. For the summary of the findings the Cochrane Collaboration Handbook recommendations will be used, and for the meta-analysis standard statistical techniques the RevMan software will be used. Results: In this study, we hope to find a considerable number of articles presenting evidence about the effectiveness of vitamin A supplementation in patients with MS. Conclusion: Currently, many lines of evidence have been produced when it comes to the use of food supplements. This systematic review proposal might provide recent, important, and trusted information for better treatment of patients. Record of systematic review: This review was recorded in the International Register of Prospective Systematic Reviews (PROSPERO) on the January 30, 2019 (registration: CRD42019121757). Available at: http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42019121757 .

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Section: Discussionmentioning

confidence: 99%

Nutritional supplementation of vitamin A and health-related outcomes in patients with multiple sclerosis

Nunes

Piuvezam²

2019

Medicine

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Immunomodulatory Properties of Nutraceuticals and Functional Foods

García-Gurrola¹,

Wall‐Medrano²,

Olivas-Aguirre³

et al. 2022

Nutraceuticals and Functional Foods in Immunomodulators

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Genetic influences on circulating retinol and its relationship to human health

Reay,

Kiltschewskij,

Di Biase

et al. 2024

Nat Commun

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Retinol is a fat-soluble vitamin that plays an essential role in many biological processes throughout the human lifespan. Here, we perform the largest genome-wide association study (GWAS) of retinol to date in up to 22,274 participants. We identify eight common variant loci associated with retinol, as well as a rare-variant signal. An integrative gene prioritisation pipeline supports novel retinol-associated genes outside of the main retinol transport complex (RBP4:TTR) related to lipid biology, energy homoeostasis, and endocrine signalling. Genetic proxies of circulating retinol were then used to estimate causal relationships with almost 20,000 clinical phenotypes via a phenome-wide Mendelian randomisation study (MR-pheWAS). The MR-pheWAS suggests that retinol may exert causal effects on inflammation, adiposity, ocular measures, the microbiome, and MRI-derived brain phenotypes, amongst several others. Conversely, circulating retinol may be causally influenced by factors including lipids and serum creatinine. Finally, we demonstrate how a retinol polygenic score could identify individuals more likely to fall outside of the normative range of circulating retinol for a given age. In summary, this study provides a comprehensive evaluation of the genetics of circulating retinol, as well as revealing traits which should be prioritised for further investigation with respect to retinol related therapies or nutritional intervention.

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A systematic review and meta-analysis of randomized controlled trials to evaluating the trend of cytokines to vitamin A supplementation in autoimmune diseases

Cited by 7 publications

References 37 publications

Nutritional supplementation of vitamin A and health-related outcomes in patients with multiple sclerosis

Nutritional supplementation of vitamin A and health-related outcomes in patients with multiple sclerosis

Immunomodulatory Properties of Nutraceuticals and Functional Foods

Genetic influences on circulating retinol and its relationship to human health

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