Nutritional supplementation of vitamin A and health-related outcomes in patients with multiple sclerosis

Abstract

Background: Multiple sclerosis (MS) is a chronic immune mediated disease which affects the central nervous system (CNS), having a substantial financial, functional, and quality of life (QOL) impact on these people. The vitamin A supplementation has been studied as a therapeutic possibility for in MS. Therefore, the objective of this protocol is to build an outline for a future systematic review, which will provide up-to-date available evidence about the clinical impact of nutritional supplementation of vitamin A in the outcomes related to the symptoms in patients with this pathology. Methods: The search will be performed in the following databases: PubMed, Embase, Scopus, cinahl, Scielo, Web of Science, the Cochrane Library and Science Direct, randomized clinical trials published until May 2019 that evaluate the relationship of the supplementation of vitamin A and health-related outcomes in patients with MS will be included. Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) will be used to outline the protocol, and PRISMA to the systematic review. Undergraduate handbook of quality of evidence and strength of recommendations for decision making in health (GRADE) will be used to assess the quality of evidence and the strength of the recommendation, and the JADAD scale to assess the internal validity of selected studies. For the extraction of all the data found a database in Microsoft Excel will be created. For the summary of the findings the Cochrane Collaboration Handbook recommendations will be used, and for the meta-analysis standard statistical techniques the RevMan software will be used. Results: In this study, we hope to find a considerable number of articles presenting evidence about the effectiveness of vitamin A supplementation in patients with MS. Conclusion: Currently, many lines of evidence have been produced when it comes to the use of food supplements. This systematic review proposal might provide recent, important, and trusted information for better treatment of patients. Record of systematic review: This review was recorded in the International Register of Prospective Systematic Reviews (PROSPERO) on the January 30, 2019 (registration: CRD42019121757). Available at: http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42019121757 .

The effects of the interplay between vitamins, antibiotics, and gut microbiota on the pathogenesis and progression of dementia: A systematic review and meta‐analysis

“…Vitamin A regulates immunological activities for central nervous system development by encouraging cell differentiation and neuron plasticity 48 . Vitamin A insufficiency induces colon inflammation, hyperplasia, inflammatory cell infiltration, and shorter villi 48 . Vitamin A improves memory and dendritic arborization in young neurons.…”

“…Oral vitamin A alters gut microbiota, favoring Lactobacillaceae. 48 Vitamin B insufficiency increases the likelihood of behavioral and cognitive impairments due to neurological and mental diseases. 16,18 Normal brain growth and function depend on vitamin B levels.…”

“…48 Vitamin A insufficiency induces colon inflammation, hyperplasia, inflammatory cell infiltration, and shorter villi. 48 Vitamin A improves memory and dendritic arborization in young neurons.…”

Effect of targeted individualized nutrition support on patients with severe diseases during hospitalization

“…Inadequate nutrient intake and impaired utilization can directly induce or aggravate systemic inflammatory responses, exacerbating organ failure (Ahmad et al, 2019). At present, enteral and parenteral nutrition support methods are widely applicated (Nunes & Piuvezam 2019). The focus of nutrition support research at present is how to implement a safe and effective nutrition support program to promote the recovery of patients with severe disease.…”

Folic Acid Is Related to Muscle Strength and Vitamin A Is Related to Health-Related Quality of Life: Results of the Korea National Health and Nutrition Examination Survey (KNHANES VII 2016–2018)

“…Vitamin A has been known to play an important role in preventing the aging process [ 19 ]. Retinoic acid, a common form of active vitamin A, may be linked to the development of regulatory T cells and enhanced responses to cancer, infection [ 34 , 35 ] and autoimmune diseases such as multiple sclerosis [ 36 ], all of which are associated with aging and quality of life.…”