A systematic review and meta-analysis of the stability of peripheral immune markers in healthy adults

Walsh, Catherine; Lindsay, Emily K.; Grosse, Philip J; Natale, Brianna N.; Fairlie, Samantha; Bwint, Amanda; Schaffer, Luke; McMahon, Katie L.; Duke, Colin Del; Forse, Jenny; Lamonje-Vicente, Noemi; Marsland, Anna L.

doi:10.1016/j.bbi.2022.09.011

Cited by 15 publications

(5 citation statements)

References 118 publications

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“…Considering the multi-year delay between collection of the blood sample at baseline and the imaging and cognitive assessments performed at follow-up 2, it is unclear how well this single measure of serum CRP represents individual's basal levels; this limitation may help explain the lack of associations found in our primary analyses. While our preliminary analyses showed stronger longitudinal associations between serum CRP concentrations taken multiple years apart in the UKBB data than reported in a recent meta-analysis ( Walsh et al, 2023 ), aggregating serum CRP measures from multiple time points could be of great value. Unfortunately, using multiple serum CRP measures was not possible in these analyses as CRP data at follow-up 1 were limited in number and follow-up 2 CRP data were unavailable.…”

Section: Discussioncontrasting

confidence: 61%

C-Reactive protein and cognition: Mediation analyses with brain morphology in the UK Biobank

Mendelson

Mizrahi

Lepage

et al. 2023

Brain, Behavior, & Immunity - Health

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Section: Discussioncontrasting

confidence: 61%

C-Reactive protein and cognition: Mediation analyses with brain morphology in the UK Biobank

Mendelson

Mizrahi

Lepage

et al. 2023

Brain, Behavior, & Immunity - Health

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“…Repeated measurement may be particularly important for inflammatory markers such as IL-6, which are subject to more diurnal variability than others (e.g., CRP; Pearson et al, 2003). Even though recent evidence supports the temporal stability of single measures of IL-6 at least over periods of days to months (Walsh et al, 2023) and there was more between-person than within-person variability in IL-6 in the current sample, repeated measures provided a more reliable assessment of IL-6. A further strength of the current study was the collection of blood samples for the assessment of IL-6 in participants' natural environments at a consistent time of day (the apex of diurnal variability), improving the ecological validity of the assessment.…”

Section: Strengths and Limitationscontrasting

confidence: 53%

Sex-specific associations between childhood trauma and adult systemic inflammation in daily life.

Natale,

Koffer,

Fairlie

et al. 2024

Health Psychology

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Objective: Childhood trauma may contribute to lifelong health through chronic systemic inflammation. However, associations between childhood trauma and inflammation are mixed, indicating that distinct types of childhood trauma may relate to inflammation differently. Moreover, most studies use a single assessment of inflammatory markers that may not reliably estimate stable interindividual differences. The current study is the first to examine relationships between childhood trauma and an ecologically valid measure of inflammation derived from repeated assessments of interleukin (IL)-6 in daily life. We also examine the possibility that glucocorticoid sensitivity and patterns of daily cortisol may contribute to observed associations. Finally, we explore whether biological sex moderates relationships between childhood trauma and IL-6. Method: Participants were 283 healthy adults aged 40-64 (57% female, 23% Black, Indigenous, and People of Color) who completed the Childhood Trauma Questionnaire and self-collected dried blood spots at home on 4 days to measure IL-6. Measures of salivary cortisol and blood-based glucocorticoid sensitivity were also assessed. Results: Childhood trauma was not associated with IL-6 in the sample as a whole. However, exploratory analyses showed that childhood trauma related to IL-6 differently for males and females, such that total trauma and emotional neglect predicted higher IL-6 for males but not females. Results persisted after adjustment for covariates. There was no evidence for indirect effects via cortisol or glucocorticoid sensitivity. Conclusions: Childhood trauma and, specifically, emotional neglect were associated with IL-6 in daily life among middle-aged males. Additional research is needed to elucidate biological and behavioral pathways underlying these associations. Public Significance StatementThe current study provides initial evidence for an association of childhood trauma with a reliable measure of systemic inflammation in adulthood, as measured over multiple days in participants' own environments. Recalled experiences of abuse and neglect were associated with higher average levels of inflammation among males but not females. Inflammation may be a pathway contributing to the increased health risk that is associated with childhood trauma.

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“…Discordance between levels of systemic cytokines and their vascular expression may be partially explained by the complexity of the inflammatory process. Cytokines are local mediators, and their production can be compartmentalized ( 49 ). Patterns of cytokine production differ under various clinical conditions, particularly in low-grade chronic inflammation, and cellular mRNA may not correspond to circulation proteins.…”

Section: Discussionmentioning

confidence: 99%

Systemic and local vascular inflammation and arterial reactive oxygen species generation in patients with advanced cardiovascular diseases

Sulicka-Grodzicka,

Szczepaniak,

Jozefczuk

et al. 2023

Front. Cardiovasc. Med.

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BackgroundSystemic inflammation may cause endothelial activation, mediate local inflammation, and accelerate progression of atherosclerosis. We examined whether the levels of circulating inflammatory cytokines reflect local vascular inflammation and oxidative stress in two types of human arteries.MethodsHuman internal mammary artery (IMA) was obtained in 69 patients undergoing coronary artery bypass graft (CABG) surgery and left anterior descending (LAD) artery was obtained in 17 patients undergoing heart transplantation (HTx). Plasma levels of tumor necrosis factor α (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β) were measured using ELISA, high-sensitivity C-reactive protein (hs-CRP) was measured using Luminex, and mRNA expression of proinflammatory cytokines in the vascular tissues was assessed. Furthermore, formation of superoxide anion was measured in segments of IMA using 5 uM lucigenin-dependent chemiluminescence. Vascular reactivity was measured using tissue organ bath system.ResultsTNF-α, IL-6 and IL-1β mRNAs were expressed in all studied IMA and LAD segments. Plasma levels of inflammatory cytokines did not correlate with vascular cytokine mRNA expression neither in IMA nor in LAD. Plasma TNF-α and IL-6 correlated with hs-CRP level in CABG group. Hs-CRP also correlated with TNF-α in HTx group. Neither vascular TNF-α, IL-6 and IL-1β mRNA expression, nor systemic levels of either TNF-α, IL-6 and IL-1β were correlated with superoxide generation in IMAs. Interestingly, circulating IL-1β negatively correlated with maximal relaxation of the internal mammary artery (r = −0.37, p = 0.004). At the same time the mRNA expression of studied inflammatory cytokines were positively associated with each other in both IMA and LAD. The positive correlations were observed between circulating levels of IL-6 and TNF-α in CABG cohort and IL-6 and IL-1β in HTx cohort.ConclusionsThis study shows that peripheral inflammatory cytokine measurements may not reflect local vascular inflammation or oxidative stress in patients with advanced cardiovascular disease (CVD). Circulating pro-inflammatory cytokines generally correlated positively with each other, similarly their mRNA correlated in the arterial wall, however, these levels were not correlated between the studied compartments.

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A systematic review and meta-analysis of the stability of peripheral immune markers in healthy adults

Cited by 15 publications

References 118 publications

C-Reactive protein and cognition: Mediation analyses with brain morphology in the UK Biobank

C-Reactive protein and cognition: Mediation analyses with brain morphology in the UK Biobank

Sex-specific associations between childhood trauma and adult systemic inflammation in daily life.

Systemic and local vascular inflammation and arterial reactive oxygen species generation in patients with advanced cardiovascular diseases

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