A Systematic Review about Effects of Aerial Portions of Urtica dioica 
 (Nettle) on Some Cardiovascular Risk Factors in Diabetes Mellitus

Namazi, Nazli; Esfanjani, A T; Heshmati, Javad; Bahrami, Amir; Nazemiyeh, H

doi:10.3923/ijp.2012.306.313

Cited by 7 publications

(2 citation statements)

References 12 publications

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“…Consequently, the tendency of people to alternative and complementary therapies have significantly increased [8]. In this regard, the anti-diabetic effects of many medicinal herbs have been studied so far [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

The effect of cinnamon supplementation on glycemic control in patients with type 2 diabetes or with polycystic ovary syndrome: an umbrella meta-analysis on interventional meta-analyses

Zarezadeh

Musazadeh

Foroumandi

et al. 2023

Diabetol Metab Syndr

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Background Several meta-analyses reported glycemic-lowering effects of cinnamon, while others reported conflicting findings. In the present study, we aimed to perform an umbrella meta-analysis of previous interventional meta-analyses on the effects of cinnamon on glycemic control in patients with type 2 diabetes (T2D) or with polycystic ovary syndrome (PCOS). Methods Relevant studies were searched in PubMed, Scopus, EMBASE, Web of Science, and Google Scholar up to June 2022. Meta-analyses of randomized clinical trials (RCTs) investigating the effects of cinnamon on glycemic indices including fasting plasma glucose (FPG), homeostatic model assessment for insulin resistance (HOMA-IR), insulin, and hemoglobin A1C (HbA1c) were included. Random-effects models were used to perform the umbrella meta-analysis and pool the weighted mean difference (WMD) or standardized mean difference (SMD) and their 95% confidence intervals (CI). Results Overall, 11 meta-analyses of RCTs were included. Cinnamon supplementation was effective in reducing serum FPG (WMD: -10.93 mg/dL; 95%CI: -16.22, -5.65; SMD: -0.86; 95%CI: -1.19, -0.52), insulin (WMD: -2.01 IU/mL; 95%CI: -3.96, -0.07; SMD: -0.61; 95%CI: -0.93, -0.30), HOMA-IR levels (WMD: -0.61; 95%CI: -0.91, -0.31; SMD: -0.78; 95%CI: -1.26, -0.30), and HbA1c (WMD: -0.10%; 95%CI: -0.17, -0.03). Conclusion Cinnamon can be used as an anti-diabetic agent and an add-on treatment to control glycemic indices among patients with T2D or PCOS.

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Section: Introductionmentioning

confidence: 99%

The effect of cinnamon supplementation on glycemic control in patients with type 2 diabetes or with polycystic ovary syndrome: an umbrella meta-analysis on interventional meta-analyses

Zarezadeh

Musazadeh

Foroumandi

et al. 2023

Diabetol Metab Syndr

View full text Add to dashboard Cite

show abstract

“…However, there is frequently insufficient data to support their benefits or safety. The effects of several medicinal plants on T2DM and obesity have already been studied (Asadi‐Samani et al, 2017; Bahmani et al, 2016; Namazi et al, 2012; Namazi et al, 2018). One of these herbs is cinnamon, which is mostly prepared from cinnamon leaves and bark of the plant.…”

Section: Introductionmentioning

confidence: 99%

The effect of cinnamon supplementation on glycemic control in patients with type 2 diabetes mellitus: An updated systematic review and dose‐response meta‐analysis of randomized controlled trials

Moridpour,

Kavyani,

Khosravi

et al. 2023

Phytotherapy Research

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Although many randomized controlled trials (RCTs) have revealed the benefits of cinnamon on type 2 diabetes mellitus (T2DM), the effects of cinnamon supplementation on glycemic control in patients with T2DM are inconclusive. Therefore, the aim of this meta‐analysis of RCTs was to assess the effects of cinnamon supplementation in managing glycemic control in patients with T2DM. Scientific international databases including Scopus, Web of Sciences, PubMed, Embase, and the Cochrane Library were searched till December 2022. For net changes in glycemic control, standard mean differences (SMDs) were calculated using random‐effects models. Findings from 24 RCTs revealed that cinnamon supplementation had a statistically significant reduction in fasting blood sugar (SMD: −1.32; 95% CI: −1.77, −0.87, p < 0.001), Homeostatic Model Assessment for Insulin Resistance (SMD: ‐1.32; 95% CI: −1.77, −0.87, p < 0.001), and hemoglobin A1C (SMD: −0.67; 95% CI: −1.18, −0.15, p = 0.011) compared with the control group in patients with T2DM. Additionally, cinnamon did not change the serum levels of insulin (SMD: −0.17; 95% CI: −0.34, 0.01, p = 0.058) significantly. Our analysis indicated that glycemic control indicators are significantly decreased by cinnamon supplementation. Together, these findings support the notion that cinnamon supplementation might have clinical potential as an adjunct therapy for managing T2DM.

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The effect of nettle (Urtica dioica) supplementation on the glycemic control of patients with type 2 diabetes mellitus: A systematic review and meta‐analysis

Ziaei

Foshati

Hadi

et al. 2019

Phytotherapy Research

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Type 2 diabetes mellitus (T2DM) is a major health problem, worldwide, that is associated with increased morbidity and mortality. Several randomized controlled clinical trials (RCTs) have investigated the effect of nettle (Urtica dioica) supplementation on markers of glycemic status in patients with T2DM, with conflicting results. Therefore, the present study assessed the effect of nettle on some glycemic parameters in patients with T2DM. A comprehensive search was conducted in PubMed, Scopus, Cochrane Library, and Web of Science, from database inception up to June 2019, to identify RCTs investigating the effect of nettle supplementation on glycemic markers, including fasting blood sugar (FBS) concentrations, insulin levels, homeostasis model assessment-estimated insulin resistance index, and glycosylated hemoglobin percentage in adults with T2DM. The Cochrane Collaboration tool was used to assess the methodological quality of the included studies. Results of this meta-analysis were reported based on the random effects model. Eight RCTs, comprising 401 participants, were included in the present systematic review and meta-analysis. Based on the Cochrane Collaboration risk of bias tool, five studies were considered as good quality, one was fair, and two studies were poor, respectively. The results of the meta-analysis revealed a significant reduction in FBS concentrations (weighted mean difference [WMD]: −18.01 mg/dl, 95% confidence interval [CI]: −30.04 to −5.97, p < .001, I 2 = 94.6%) following nettle supplementation. However, no significant reduction was observed in insulin levels (WMD: 0.83 Hedges' g, 95% CI: −0.26 to 1.92, p = .13, I 2 = 89.4%), homeostasis model assessment-estimated insulin resistance index (WMD: −0.22, 95% CI: −0.83 to 0.40, p = .49, I 2 = 69.2%), or glycosylated hemoglobin percentage (WMD: −0.77%, 95% CI: −1.77 to 0.22, p = .12, I 2 = 83.0%). The find-ings of the present study suggest that nettle supplementation may be effective in controlling FBS for T2DM patients. However, further studies are needed to confirm the veracity of these results. K E Y W O R D Sglycemic markers, meta-analysis, nettle, systematic review, type 2 diabetes mellitus

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A Systematic Review about Effects of Aerial Portions of Urtica dioica (Nettle) on Some Cardiovascular Risk Factors in Diabetes Mellitus

Cited by 7 publications

References 12 publications

The effect of cinnamon supplementation on glycemic control in patients with type 2 diabetes or with polycystic ovary syndrome: an umbrella meta-analysis on interventional meta-analyses

The effect of cinnamon supplementation on glycemic control in patients with type 2 diabetes or with polycystic ovary syndrome: an umbrella meta-analysis on interventional meta-analyses

The effect of cinnamon supplementation on glycemic control in patients with type 2 diabetes mellitus: An updated systematic review and dose‐response meta‐analysis of randomized controlled trials

The effect of nettle (Urtica dioica) supplementation on the glycemic control of patients with type 2 diabetes mellitus: A systematic review and meta‐analysis

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