A systematic literature review of observational studies of the bilateral association between diabetes and migraine

Hosseinpour, Marjan; Maleki, Farzad; Khoramdad, Maliheh; Sullman, Mark J.M.; Nejadghaderi, Seyed Aria; Kolahi, Ali‐Asghar; Safiri, Saeid

doi:10.1016/j.dsx.2021.03.018

Cited by 13 publications

(24 citation statements)

References 25 publications

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“…This study demonstrated a higher rate of dementia events in patients with migraine than in those without migraine [26]. Moreover, it is generally accepted that the increased cardiovascular risk of migraine is a composite effect of multiple parameters, such as hypertension, diabetes mellitus, obesity, and dyslipidaemia [27][28][29][30]. Thus, our results support the hypothesis that migraine in midlife may be a risk factor for dementia in later life, specifically for Alzheimer's disease.…”

Section: Discussionsupporting

confidence: 84%

Mid- and Late-Life Migraine Is Associated with an Increased Risk of All-Cause Dementia and Alzheimer’s Disease, but Not Vascular Dementia: A Nationwide Retrospective Cohort Study

Lee

Myeong

et al. 2021

JPM

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We used a nationwide cohort sample of data from 2002 to 2013, representing approximately 1 million patients to investigate the prospective association between migraine and dementia. The migraine group (n = 1472) included patients diagnosed between 2002 and 2004, aged over 55 years; the comparison group was selected using propensity score matching (n = 5888). Cox proportional hazards regression analyses was used to calculate the hazard ratios (HRs). The incidence of dementia was 13.5 per 1000 person-years in the migraine group. Following adjustment for sociodemographic and comorbidities variables, patients with migraine developed dementia more frequently than those in the comparison group (adjusted HR = 1.37, 95% confidence interval [CI], 1.16–1.61). In the subgroup analysis, we found a higher HR of dementia events in male, the presence of comorbidities, and older age (≥65) patients with migraine, compared to those without migraine. Moreover, patients with migraine had a significantly higher incidence of Alzheimer’s disease (adjusted HR = 1.31, 95% CI, 1.08–1.58), but not vascular dementia, than those without migraine. Therefore, our findings suggest that mid- and late-life migraines may be associated with an increased incidence of all-cause dementia and Alzheimer’s disease, but not vascular dementia.

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Section: Discussionsupporting

confidence: 84%

Mid- and Late-Life Migraine Is Associated with an Increased Risk of All-Cause Dementia and Alzheimer’s Disease, but Not Vascular Dementia: A Nationwide Retrospective Cohort Study

Lee

Myeong

et al. 2021

JPM

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“…We highly recommend a recently published systematic literature review by Hosseinpour et al ( 172 ) for a comprehensive overview of studies on the association between migraine and DM.…”

Section: Association Between Migraine and Diabetes Mellitus (Dm)mentioning

confidence: 99%

“…However, controlling for these confounders might take away potential associations between migraine and obesity and effect-modifiers, including attack frequency, age, and sex, but also perceived stress ( 196 ). Remarkably, studies on the association between migraine and DM have identified a more limited amount of effect-modifiers, mainly due to the lack of stratification of their results (e.g., sex-specific estimates) ( 172 ). Yet, obesity should be considered as an effect-modifier in the association between migraine and DM (or IR) ( 194 ).…”

Section: Future Implicationsmentioning

confidence: 99%

“…Therefore, the use of these medications might be an overlooked confounding factor in the probable bidirectional relationship between migraines and obesity. A similar restriction applies to studies on the association between DM and migraine, which lack data on drug use that not only influence weight, but also insulin sensitivity ( 172 ). Another cause of the observed variability might be related to the fact that not all articles used the same indices of obesity.…”

Section: Future Implicationsmentioning

confidence: 99%

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Metabolic Aspects of Migraine: Association With Obesity and Diabetes Mellitus

et al. 2021

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Migraine is a disabling neurovascular disorder, characterized by moderate to severe unilateral headaches, nausea, photophobia, and/or phonophobia, with a higher prevalence in women than in men, which can drastically affect the quality of life of migraine patients. In addition, this chronic disorder is related with metabolic comorbidities associated with the patient's lifestyle, including obesity and diabetes mellitus (DM). Beyond the personal and socioeconomic impact caused by migraine, obesity and DM, it has been suggested that these metabolic disorders seem to be related to migraine since: (i) they are a risk factor for developing cardiovascular disorders or chronic diseases; (ii) they can be influenced by genetic and environmental risk factors; and (iii) while clinical and epidemiological studies suggest that obesity is a risk factor for migraine, DM (i.e., type 1 and type 2 DM) have been reported to be either a protective or a risk factor in migraine. On this basis, and given the high worldwide prevalence of migraine, obesity, and DM, this article provides a narrative review of the current literature related to the association between the etiology and pathophysiology of migraine and these metabolic disorders, considering lifestyle aspects, as well as the possible involvement of neurotransmitters, neuropeptides, and/or sex hormones. While a link between migraine and metabolic disorders has been suggested, many studies are contradictory and the mechanisms involved in this association are not yet sufficiently established. Therefore, further research should be focused on understanding the possible mechanisms involved.

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“…Notwithstanding, some limitations inevitably existed in this umbrella review. Firstly, results of individual observational investigations involving under-developed meta-analysis were beyond the scope of this review, such as the concentration of lipoprotein(a) (57) and diabetes (58). Thus, we might have missed some researches on the links between migraine and multiple health/medical endpoints.…”

Section: Discussionmentioning

confidence: 99%

Migraine and Medical Ramifications: A Comprehensive Overview Based on Observational Study Meta-Analyses

et al. 2021

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Purpose: An umbrella review was conducted for comprehensively evaluating previous review-based literature together with meta-analysis of observational investigations probing correlations between migraine and medical end-point ramifications in patients. The breadth and validity of these associations were assessed.Methods: Multiple online scientific repositories (including PubMed, Medline, Embase, and Web of Science) were investigated (inception-August 2021) for related meta-analyses focusing on links between migraine and all possible health/medical ramification end-points. A summary effect size and 95% CIs were determined for each identified study with such links. Heterogeneity and small-study influence traces were also evaluated. The AMSTAR 2 platform was employed for evaluating standards of methodology, together with objective criteria, for assessing the standards of datasets from each medical end-point scrutinized in this study.Results: A total of 25 scientific reports comprising 10,237,230 participants for 49 meta-analyses of observational studies were selected. Among such 49 outcomes, 30 demonstrated statistical significance (P < 0.05). Significant associations were observed in multiple diseases, including cardiovascular/cerebrovascular, cerebral, pregnancy-related and metabolic disorders, other outcomes, and mortality.Conclusion: The results showed that migraine increased the risk of 29 health outcomes, though lowered the risk of breast cancer. However, evidence quality was graded as high only for angina. The evidence quality of ischaemic stroke, stroke, MACCE, WMAs, and asthma was graded as moderate. All remaining 24 outcomes had an evidence grade of “weak.”

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A systematic literature review of observational studies of the bilateral association between diabetes and migraine

Cited by 13 publications

References 25 publications

Mid- and Late-Life Migraine Is Associated with an Increased Risk of All-Cause Dementia and Alzheimer’s Disease, but Not Vascular Dementia: A Nationwide Retrospective Cohort Study

Mid- and Late-Life Migraine Is Associated with an Increased Risk of All-Cause Dementia and Alzheimer’s Disease, but Not Vascular Dementia: A Nationwide Retrospective Cohort Study

Metabolic Aspects of Migraine: Association With Obesity and Diabetes Mellitus

Migraine and Medical Ramifications: A Comprehensive Overview Based on Observational Study Meta-Analyses

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