2013
DOI: 10.1186/1479-5876-11-57
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A systematic evaluation of miRNA:mRNA interactions involved in the migration and invasion of breast cancer cells

Abstract: In this study we performed a systematic evaluation of functional miRNA-mRNA interactions associated with the invasiveness of breast cancer cells using a combination of integrated miRNA and mRNA expression profiling, bioinformatics prediction, and functional assays. Analysis of the miRNA expression identified 11 miRNAs that were differentially expressed, including 7 down-regulated (miR-200c, miR-205, miR-203, miR-141, miR-34a, miR-183, and miR-375) and 4 up-regulated miRNAs (miR-146a, miR-138, miR-125b1 and miR… Show more

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Cited by 122 publications
(108 citation statements)
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“…Previous studies have indicated that the expression pattern of miR-141 varies in different malignant tumors. It has been observed that miR-141 was downregulated in pancreatic cancer, renal cancer, hepatocellular carcinoma, and breast cancer, whereas it was upregulated in colorectal cancer and prostate cancer (Yaman Agaoglu et al, 2011;Maruyama et al, 2012;Brunet Vega et al, 2013;Luo et al, 2013;Yu et al, 2013;Yeh et al, 2014). Furthermore, it was also shown that the expression level of miR-141 was associated with cancerspecific survival.…”
Section: Discussionmentioning
confidence: 98%
“…Previous studies have indicated that the expression pattern of miR-141 varies in different malignant tumors. It has been observed that miR-141 was downregulated in pancreatic cancer, renal cancer, hepatocellular carcinoma, and breast cancer, whereas it was upregulated in colorectal cancer and prostate cancer (Yaman Agaoglu et al, 2011;Maruyama et al, 2012;Brunet Vega et al, 2013;Luo et al, 2013;Yu et al, 2013;Yeh et al, 2014). Furthermore, it was also shown that the expression level of miR-141 was associated with cancerspecific survival.…”
Section: Discussionmentioning
confidence: 98%
“…A systematic evaluation of functional miRNA-mRNA interactions associated with the invasiveness of breast cancer cells has revealed that miR-205 was included in a group of 7 downregulated miRNAs in invasive cell lines compared to normal and less invasive cell lines (34 ). It has recently been reported that miR-205 is a tumor suppressor in breast cancer, because breast cancer cell lines express a lower level of miR-205 than nonmalignant cells, and that ectopic expression of miR-205 significantly inhibits cell proliferation and anchorageindependent growth, as well as cell invasion (35 ).…”
Section: Discussionmentioning
confidence: 99%
“…The ability of tumor cells to invade and destroy neighboring tissues and organs, as well as migrate to other parts of the body, is crucial to the metastatic process [118,119]. It has been increasingly recognized that miRNAs play important roles in tumor invasiveness and metastasis [120][121][122]. For example, Shi et al showed that lower expression of miR-100 could promote the migration and invasion of gastric cancer cells without significant alteration of proliferation [8].…”
Section: Mir-100 In Cancer Invasion and Metastasismentioning
confidence: 99%