A System Based-Approach to Examine Host Response during Infection with Influenza A Virus Subtype H7N9 in Human and Avian Cells

Taye, Biruhalem; Chen, Hui; Yeo, David; Seah, Shirley Gek Kheng; Wong, Michelle; Sugrue, Richard J.; Tan, Boon Huan

doi:10.3390/cells9020448

Cited by 2 publications

(2 citation statements)

References 45 publications

(60 reference statements)

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“…COVID-19 has this kind of performance, but it is not as obvious as SARS. The prospective studies showed that increased CRP levels were associated with progressive abnormalities in patients with SARS related pneumonia and could be predictive of severity and death (49)(50)(51)(52)(53). Following 8 years of SARS, the association between SARS epidemic and Chinese older people revealed that community SARS exposure in the Chinese older adults was more strongly related to high CRP levels (54).…”

Section: Crp and Other Viral Infections Crp And Sarsmentioning

confidence: 99%

Update Advances on C-Reactive Protein in COVID-19 and Other Viral Infections

2021

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Severe coronavirus disease 2019 (COVID-19) can manifest as a viral-induced hyperinflammation with multiorgan dysfunction. It has been documented that severe COVID-19 is associated with higher levels of inflammatory mediators than a mild disease, and tracking these markers may allow early identification or even prediction of disease progression. It is well known that C-reactive protein (CRP) is the acute-phase protein and the active regulator of host innate immunity, which is highly predictive of the need for mechanical ventilation and may guide escalation of treatment of COVID-19-related uncontrolled inflammation. There are numerous causes of an elevated CRP, including acute and chronic responses, and these can be infectious or non-infectious in etiology. CRP are normally lacking in viral infections, while adaptive immunity appears to be essential for COVID-19 virus clearance, and the macrophage activation syndrome may explain the high serum CRP contents and contribute to the disease progression. Nevertheless, for the assessment of host inflammatory status and identification of viral infection in other pathologies, such as bacterial sepsis, the acute-phase proteins, including CRP and procalcitonin, can provide more important information for guiding clinical diagnosis and antibiotic therapy. This review is aimed to highlight the current and most recent studies with regard to the clinical significance of CRP in severe COVID-19 and other viral associated illnesses, including update advances on the implication of CRP and its form specifically on the pathogenesis of these diseases. The progressive understanding in these areas may be translated into promising measures to prevent severe outcomes and mitigate appropriate treatment modalities in critical COVID-19 and other viral infections.

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Section: Crp and Other Viral Infections Crp And Sarsmentioning

confidence: 99%

Update Advances on C-Reactive Protein in COVID-19 and Other Viral Infections

2021

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“…In the early stage of H7N9 infection, the HIPPO pathway activates in avian cells, but not in human cells. The pathway allows the H7N9 virus to remain in its low pathogenicity form in the avian host, resulting in a non-diseased state during an H7N9 epidemic [ 27 ]. Interestingly, we found activation of the HIPPO pathway in NHBE cells in the middle and late stages of H7N9 infection, but not in pdmH1N1 infection.…”

Section: Discussionmentioning

confidence: 99%

Transcriptome Differences in Normal Human Bronchial Epithelial Cells in Response to Influenza A pdmH1N1 or H7N9 Virus Infection

Hsieh

Lin

Hsioa

et al. 2022

Cells

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Avian influenza A (H7N9) virus infections frequently lead to acute respiratory distress syndrome and death in humans. The emergence of H7N9 virus infections is a serious public health threat. To identify virus–host interaction differences between the highly virulent H7N9 and pandemic influenza H1N1 (pdmH1N1), RNA sequencing was performed of normal human bronchial epithelial (NHBE) cells infected with either virus. The transcriptomic analysis of host cellular responses to viral infection enables the identification of potential cellular factors related to infection. Significantly different gene expression patterns were found between pdmH1N1- and H7N9-infected NHBE cells. In addition, the H7N9 virus infection induced strong immune responses, while cellular repair mechanisms were inhibited. The differential expression of specific factors observed between avian H7N9 and pdmH1N1 influenza virus strains can account for variations in disease pathogenicity. These findings provide a framework for future studies examining the molecular mechanisms underlying the pathogenicity of avian H7N9 virus.

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A System Based-Approach to Examine Host Response during Infection with Influenza A Virus Subtype H7N9 in Human and Avian Cells

Cited by 2 publications

References 45 publications

Update Advances on C-Reactive Protein in COVID-19 and Other Viral Infections

Update Advances on C-Reactive Protein in COVID-19 and Other Viral Infections

Transcriptome Differences in Normal Human Bronchial Epithelial Cells in Response to Influenza A pdmH1N1 or H7N9 Virus Infection

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