A Synergistic Formulation of Plant Extracts Decreases Postprandial Glucose and Insulin Peaks: Results from Two Randomized, Controlled, Cross-Over Studies Using Real-World Meals

Abstract

This study investigated the efficacy of a plant-derived dietary supplement with respect to decreasing postprandial glucose and insulin peaks after the intake of real-world meals. Two randomized, double-blind, placebo-controlled, cross-over experiments were conducted on healthy subjects who received a supplement containing extracts of white mulberry, white bean, and green coffee or one containing the three extracts with added fibre before consuming high-GI/GL (glycaemic index/glycaemic load) meals. In study one, 32 subjects received an investigational product/placebo before a standardized meal at two visits. In study two, 150 subjects received an investigational product/placebo before five different standardized meals. Postprandial glucose and insulin concentrations were lower 20–35 min after meal intake among subjects taking the investigational product, and fewer episodes of postprandial reactive hypoglycaemia were noted. For example, after consuming breakfast cereal with milk, lower glucose peaks were observed for the investigational product (vs. placebo) after 20 min (100.2 ± 1.97 vs. 112.5 ± 3.12 mg/dL, respectively; p < 0.01); lower insulin peaks were noted at the same time point (45.9 ± 4.02 IU/mL vs. 68.2 ± 5.53 IU/mL, respectively, p < 0.01). The combined formulation decreases the adverse consequences of high-GI/GL meal consumption. It can be an effective dietary supplement for the management of metabolic syndrome and type 2 diabetes mellitus.

Antioxidant activity, α-glucosidase inhibition and phytochemical profiling of Hyophorbe lagenicaulis leaf extracts

“…Another investigation revealed that phytochemicals from plants not only reduce the blood glucose level during diabetes but also improves the hematological parameters (Sudasinghe & Peiris, 2018). The antioxidant and anti-α-glucosidase potentials of H. lagenicaulis extracts were probably due to synergic behavior commonly observed with biologically functional plant extracts (Adamska-Patruno et al, 2018). The presence of high value bioactives in plants supports the efforts being made in search of safe and healthy therapeutic approaches for DMT-2 management.…”

Breakfast Skipping in a Multi-Ethnic Population of Middle-Aged Men and Relationship With Sociodemographic Variables and Weight Status

“…This could result in overeating and impaired insulin sensitivity. On the other hand, breakfast eating can aid in controlling appetite while also improving insulin sensitivity for the next meal (16,23). Furthermore, fasting from the previous night is interrupted by eating breakfast.…”

Peer Review #1 of "Antioxidant activity, α-glucosidase inhibition and phytochemical profiling of Hyophorbe lagenicaulis leaf extracts (v0.1)"

“…Another investigation revealed that phytochemicals from plants not only reduce the blood glucose level during diabetes but also improves the hematological parameters (Sudasinghe et al, 2018). The antioxidant and anti-α-glucosidase potentials of H. lagenicaulis extracts were probably due to synergic behavior commonly observed with biologically functional plant extracts (Adamska-Patruno, 2018). The presence of high value bioactives in plants supports the efforts being made in search of safe and healthy therapeutic approaches for DMT-2 management.…”