A suspected new species of Leishmania, the causative agent of visceral leishmaniasis in a Thai patient

Sukmee, Theerayudh; Siripattanapipong, Suradej; Mungthin, Mathirut; Worapong, J.; Rangsin, Ram; Samung, Yudthana; Kongkaew, Wandee; Bumrungsana, Kusak; Chanachai, Karoon; Apiwathanasorn, Chamnan; Rujirojindakul, Pairaya; Wattanasri, Somsak; Ungchusak, Kumnun; Leelayoova, Saovanee

doi:10.1016/j.ijpara.2007.12.003

Cited by 87 publications

(79 citation statements)

References 22 publications

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“…Phang-nga, 15 4. Chanthaburi, 18 15 The map of Thailand shows sporadic cases of CL and VL reported in six southern, one central, one eastern, and four northern provinces. Table 3 shows the characteristics of published leishmaniasis cases in Thailand from 1999 to 2016.…”

Section: Situation Of Leishmaniasis In Thailandmentioning

confidence: 99%

“…Moreover, evidence of zoonotic transmission has been demonstrated when CL caused by L. martiniquensis was reported in farm animals, that is, horses in Germany, 16 bovines in Switzerland, 17 and one horse in Florida, 21 of which sequence analysis of the ITS1 of the SSU-rRNA gene of Leishmania DNA was similar to the species of Leishmania reported in Thailand. 15 Thus, zoonotic transmission of leishmaniasis in Thailand could be similar to that of L. infantum in Europe and the Mediterranean Basin.…”

Section: Animal Reservoirsmentioning

confidence: 99%

“…E-mail: sleelayoova@gmail.com As shown in Table 2, all L. siamensis published papers from 2008 to 2016 [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] were reviewed and the species of Leishmania were confirmed using nucleotide sequences of the SSU-rRNA, ITS1 region of SSU-rRNA, and hsp70 genes from GenBank database and were compared with the nucleotide sequences of each gene using axenic cul- those reported in horses and cow. 16,17,21 Only one published paper by Bualert and others in 2012 identified L. siamensis infection.…”

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Leishmaniasis in Thailand: A Review of Causative Agents and Situations

et al. 2017

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Abstract. Before 1999, leishmaniasis was considered an imported disease in Thailand. Since then, autochthonous leishmaniasis was reported in both immmunocompetent and immmunocompromised patients especially in human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS). A new species was identified and named as Leishmania siamensis consisting of two lineages, that is, lineages TR and PG. Analysis of isoenzymes has clarified the more commonly detected L. siamensis lineage PG as Leishmania martiniquensis (MON-229), a species originally reported from the Martinique Island, whereas the L. siamensis lineage TR has been identified as the true novel species, L. siamensis (MON-324). Both cutaneous leishmaniasis (CL) and visceral leishmaniasis (VL) have been found among Thai patients. Disseminated CL and VL could be presented in some reported patients who had HIV/AIDS coinfection. So far, only sporadic cases have been reported; thus, the true prevalence of leishmaniasis should be determined in Thailand among the high-risk populations such as people with HIV/AIDS. A recent survey among animals identified L. martiniquensis DNA in black rats (Rattus rattus) suggesting a potential animal reservoir. In addition, L. martiniquensis DNA was identified in Sergentomyia gemmea and Sergentomyia barraudi, the predominant sandfly species in the affected areas. However, further studies are needed to prove that these sandflies could serve as the vector of leishmaniasis in Thailand.

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Section: Situation Of Leishmaniasis In Thailandmentioning

confidence: 99%

Section: Animal Reservoirsmentioning

confidence: 99%

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Leishmaniasis in Thailand: A Review of Causative Agents and Situations

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“…[2][3][4] In 2008, a new causative species of autochthonous visceral leishmaniasis Leishmania siamensis was described for the first time by Sukmee and others. 5 From then on, more than 10 cases of autochthonous leishmaniasis caused by L. siamensis have been occasionally reported. Until recently, it has been evident that most of the so-called L. siamensis are Leishmania martiniquensis.…”

Section: Introductionmentioning

confidence: 99%

Disseminated Autochthonous Dermal Leishmaniasis Caused by Leishmania siamensis (PCM2 Trang) in a Patient from Central Thailand Infected with Human Immunodeficiency Virus

et al. 2017

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Abstract. Several case reports of autochthonous leishmaniasis in Thailand have been published since 1996. Most of the previous cases presented with visceral leishmaniasis (VL) and were mostly reported in southern part of Thailand. Recently, it has been evident that Leishmania martiniquensis is the main cause of Leishmania infection in Thailand. However, Leishmania siamensis (PCM2 Trang isolate) was found to be of a separate lineage with restricted distribution in southern Thailand and also a cause of disseminated dermal and visceral leishmaniasis in one published case. Here we report the first patient from central Thailand with human immunodeficiency virus infection presenting with disseminated dermal leishmaniasis. Polymerase chain reaction and DNA sequencing analysis (large subunit of RNA polymerase II and 18S ribosomal RNA internal transcribed spacer 1) from the tissue biopsy sample revealed the pathogen sequences to be highly homologous to PCM2 Trang strain previously reported from southern Thailand.

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“…In 2008, the first case of visceral leishmaniasis (VL) caused by a new species, L. siamensis, was described. 1 This parasite was characterized by molecular methods. In 2010, a second case of L. siamensis infection was reported in a human immunodeficiency virus (HIV)-infected patient.…”

Section: Introductionmentioning

confidence: 99%

Autochthonous Disseminated Dermal and Visceral Leishmaniasis in an AIDS Patient, Southern Thailand, Caused by Leishmania siamensis

Bualert¹,

Charungkiattikul²,

Thongsuksai³

et al. 2012

The American Journal of Tropical Medicine and Hygiene

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Abstract. We report the first establishment of in vitro cultivation and genotypic characterization of Leishmania siamensis isolated from an autochthonous disseminated dermal and visceral leishmaniasis in a Thai acquired immunodeficiency syndrome (AIDS) patient. The molecular identification has shown that the parasite was identical to L. siamensis, a recently described Leishmania species reported in the southern provinces of Thailand. The phylogenetic analysis has confirmed L. siamensis as closely related to the zoonotic Leishmania species L. enrietti.

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A suspected new species of Leishmania, the causative agent of visceral leishmaniasis in a Thai patient

Cited by 87 publications

References 22 publications

Leishmaniasis in Thailand: A Review of Causative Agents and Situations

Leishmaniasis in Thailand: A Review of Causative Agents and Situations

Disseminated Autochthonous Dermal Leishmaniasis Caused by Leishmania siamensis (PCM2 Trang) in a Patient from Central Thailand Infected with Human Immunodeficiency Virus

Autochthonous Disseminated Dermal and Visceral Leishmaniasis in an AIDS Patient, Southern Thailand, Caused by Leishmania siamensis

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