A Survey on Synthesis Processes of Structured Materials for Biomedical Applications: Iron-based Magnetic Nanoparticles, Polymeric Materials and Polymerization Processes

Neto, Weslany Silvério; Jensen, Alan Thyago; Ferreira, Gabriella Ribeiro; Valadares, Leonardo Fonseca; Gambetta, Rossano; Gonçalves, Sílvia Belém; Machado, Fabricio

doi:10.2174/1381612821666150917093031

Cited by 12 publications

(5 citation statements)

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“…Polymeric materials-based nanoparticles (NPs) represent one of the most widely applied drug delivery systems in nanomedicine due to their excellent biocompatibility and high drug-loading efficacy [ 16–18 ]. Moreover, this type of NPs was easy to realize the structural modification such as decoration with tumor-homing peptides or aptamers on its surface for tumor targeting drug delivery [ 19–21 ].…”

Section: Introductionmentioning

confidence: 99%

Tumor targetable and pH-sensitive polymer nanoparticles for simultaneously improve the Type 2 Diabetes Mellitus and malignant breast cancer

Tang

Wen

et al. 2022

Bioengineered

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In the recent study, we have developed novel tumor targetable and pH-sensitive PLGA nanoparticles co-loaded with camptothecin (CPT) and metformin (Metf) to simultaneously improve the Type 2 Diabetes Mellitus (T2DM) and malignant breast cancer. To improve the drug loading efficiency, the hydrophobic CPT was conjugated with PLGA polymer by the pH-sensitive hydrazone bonds (hyd). Then, the Metf was physically loaded into the hydrophobicity inner core of CPT-conjugated PLGA nanocomplex to form the dual drugs-loaded nanoparticles (NP/CPT-Metf). Furthermore, on the surface of NP/CPT-Metf was modified with tumor-homing CGKRK peptides to obtain the tumor targetable and pH-sensitive polymer nanoparticles (CNP/CPT-Metf). It was demonstrated that the developed CNP/CPT-Metf displayed sufficient sensitivity to the weak acidic tumor microenvironment. Besides, excellent ability of CNP/CPT-Metf to mediate accumulation of drugs in cells and tumor tissues finally in turn resulted in a signal enhanced anti-tumor effect. Furthermore, it was demonstrated as well that CNP/CPT-Metf was able of significantly alleviating the type 2 diabetes mellitus in diabetic mice. In summary, the developed multifunctional polymer nanoparticles might represent a promising strategy for simultaneously improve the T2DM and treat malignant breast cancer.

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Section: Introductionmentioning

confidence: 99%

Tumor targetable and pH-sensitive polymer nanoparticles for simultaneously improve the Type 2 Diabetes Mellitus and malignant breast cancer

Tang

Wen

et al. 2022

Bioengineered

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“…The emulsion polymerization process is a powerful tool for the production of nanosized polymeric NPs [ 28 ]. This process involves emulsification of hydrophobic monomers by an oil-in-water emulsifier, then reaction initiation with a water-soluble initiator (e.g., potassium persulfate (K 2 S 2 O 8 )) [ 29 ]. Photochromic latex containing 1′-(2-acryloxyethyl)-3′3′-dimethyl-6-nitrospiro-(2-H-1-benzopyran-2,2′-indoline (spiropyran ethyl acrylates) showed robust photoactivity under UV radiation [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of Poly (Styrene–Acrylic Acid) Latex Nanoparticles on Colorectal and Cervical Cancer Cells

et al. 2021

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Polymer nanoparticles are a promising approach for cancer treatment and detection, due to their biocompatibility, biodegradability, targeting capabilities, capacity for drug loading and long blood circulation time. This study aims to evaluate the impact of poly (styrene–acrylic acid) latex particles on colorectal and cervical cancer cells for anti-tumor efficiency. Latex particles were synthesized by a surfactant-free radical emulsion polymerization process and the obtained polymer particles were characterized in terms of size, size distribution, morphology using scanning electron microscopy (SEM) and transmission electron microscopy (TEM), and electrokinetic property (i.e., zeta potential). Human colorectal and cervical cancer, and normal cell lines, were then treated with different concentrations of poly (styrene–acrylic acid) latex particles. The cell morphology changes were pointed out using an optical microscope and the nanoparticles’ (NPs) cell cytotoxicity was evaluated using MTT assay. The obtained results showed that poly (styrene–acrylic acid) latex particles are effective against colorectal and cervical cancer cells if treated with an appropriate particle concentration for 48 h. In addition, it showed that normal cells are the least affected by this treatment. This indicates that these NPs are safe as a drug delivery carrier when used at a low concentration.

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“…Emulsion polymerization of latex initiate with water soluble initiator (e.g. potassium persulfate, KPS) or with oil soluble initiator (2,2'-azobisisobutyronitrile, AIBN) [12,13]. Typical polymerization monomers formed vinyl monomers structure (CH₂= CH-), as emulsion polymerization is a process involving nucleation step, propagation step and termination step.…”

Section: Introductionmentioning

confidence: 99%

Synthesis Polymer Styrene Butadiene Hybrid Latex with Laponite Organoclay as Filler via Emulsion Polymerization Technique for Application in Paper Coating

Soegijono¹,

Chanra²,

Zhongwu³

et al. 2019

Preprint

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Synthesis of styrene butadiene hybrid latex was performed via emulsion polymerization technique using various amount of laponite clay as filler. Laponite clay was modified with cationic surfactant methyl triphenylphosphonium bromide (MTPB) with ion exchange technique prior to polymerization process. The main objective of the modification is to render the surface of the clay layers to more organophilic. Emulsion polymerization was performed under semi batch process using 2 L laboratory stainless steel reactor with temperature 85°C to 90°C for 8 hours. Polymer hybrid styrene butadiene latex was characterized for its physical and chemical properties with standard ASTM Methods. Characterization of its binding and printing properties were carried out with standard testing method (TAPPI Methods) using single coating formulation on 80 gsm woodfree paper. Polymer hybrid latex based on styrene and butadiene monomers with laponite clay enhanced binding and printing properties of coated paper, addition of laponite clay to 6.0 wt % increased the binding resistance of the coated paper two times higher than pure latex. Reducing binder level become possible for cost saving.

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A Survey on Synthesis Processes of Structured Materials for Biomedical Applications: Iron-based Magnetic Nanoparticles, Polymeric Materials and Polymerization Processes

Cited by 12 publications

References 0 publications

Tumor targetable and pH-sensitive polymer nanoparticles for simultaneously improve the Type 2 Diabetes Mellitus and malignant breast cancer

Tumor targetable and pH-sensitive polymer nanoparticles for simultaneously improve the Type 2 Diabetes Mellitus and malignant breast cancer

Impact of Poly (Styrene–Acrylic Acid) Latex Nanoparticles on Colorectal and Cervical Cancer Cells

Synthesis Polymer Styrene Butadiene Hybrid Latex with Laponite Organoclay as Filler via Emulsion Polymerization Technique for Application in Paper Coating

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