Impact of Poly (Styrene–Acrylic Acid) Latex Nanoparticles on Colorectal and Cervical Cancer Cells

Abstract

Polymer nanoparticles are a promising approach for cancer treatment and detection, due to their biocompatibility, biodegradability, targeting capabilities, capacity for drug loading and long blood circulation time. This study aims to evaluate the impact of poly (styrene–acrylic acid) latex particles on colorectal and cervical cancer cells for anti-tumor efficiency. Latex particles were synthesized by a surfactant-free radical emulsion polymerization process and the obtained polymer particles were characterized in terms of size, size distribution, morphology using scanning electron microscopy (SEM) and transmission electron microscopy (TEM), and electrokinetic property (i.e., zeta potential). Human colorectal and cervical cancer, and normal cell lines, were then treated with different concentrations of poly (styrene–acrylic acid) latex particles. The cell morphology changes were pointed out using an optical microscope and the nanoparticles’ (NPs) cell cytotoxicity was evaluated using MTT assay. The obtained results showed that poly (styrene–acrylic acid) latex particles are effective against colorectal and cervical cancer cells if treated with an appropriate particle concentration for 48 h. In addition, it showed that normal cells are the least affected by this treatment. This indicates that these NPs are safe as a drug delivery carrier when used at a low concentration.

Comprehensive analysis of cationic dye removal from synthetic and industrial wastewater using a semi-natural curcumin grafted biochar/poly acrylic acid composite hydrogel

“…The carboxyl and hydroxyl groups of the applied biochar and the carboxylic acid of the PAA in the area of the slipping plane are the origins of the lowered zeta potential and negative surface charge. 63 The second possible source of the zeta potential drop is the shift of the slipping plane driven by the presence of the PAA adsorption layer. 64 The negative surface charge of the adsorbent in a wide range of pHs provides its potential interaction with positively charged organic and inorganic species.…”