Poultry and swine production play an important role in countries' socioeconomic development by providing proteins that support food and nutrition security. However, several infectious and non-infectious diseases hinder the production of swine and poultry. Therefore, this review aim to provide highlight of the common disease and health management of poultry and swine. Poultry production has suffered from different pathogenic microorganisms that cause devastating economic losses in poultry industries worldwide. Poultry can be infected with common diseases like endoparasites, ectoparasites, infectious bronchitis, Marek's disease, fowl cholera, salmonellosis, infectious coryza, fowl pox, avian encephalomyelitis, etc. Health management is a system of preventive medicine that considers the whole poultry farms and the total influences, including social, with respect to relationships with others in the flock, psychological, and environmental factors that affect health. Swine production can be destructed by the influence of infectious diseases, which include Mycoplasma Hyopneumoniae, Actinobacillus pleuropneumoniae, Porcine Reproductive and Respiratory Syndrome Virus, Trichinella spp., Toxoplasma gondii, Salmonella spp., Campylobacter, and Leprospira. This all causes respiratory problems, leg problems, reproductive disorders, gastrointestinal problems, claw and skin problems, parasitic infections, and piglet mortality. Endoparasites and ectoparasites are regarded as the most significant constraints for welfare and health, as well as economic loss, in swine production, particularly during the post-weaning period. However, health management of swine production can reduce the effect of disease and optimize their productivity. Herd health management practices include vaccination, genetic improvement, and observation for all animals’ clinical signs, record keeping, detection and treatment of injury, sanitation, disease, pest control, and animal handlers. Generally, disease has a great risk to the health of poultry and swine animals that causes a decrement in their production. Therefore, the health management on poultry and swine farms should have to be strictly measured and further studies need to be conducted to solve the major problem of economic loss of production.