This paper presents a calibration-free, 16-channel, 14-bit, 50-MS/s, pipelined successive approximation register (pipelined-SAR) analog-to-digital converter (ADC) for ultrasound imaging systems. A reference sharing scheme with reduced buffers is proposed to improve area-and-power efficiency, which is essential for multi-channel systems. Based on this, a three-stage, pipelined-SAR ADC architecture with reference/op-amp sharing and optimized stage resolution distribution is proposed. The prototype ADC is designed in a 0.18-μm process with peripheral circuits integrated, including low-voltage differential signaling (LVDS), bandgap, etc. It achieves a robust and calibration-free performance with 68.25-dB signal to noise and distortion ratio (SNDR) and 82.19-dB spurious-free dynamic range (SFDR), translating into a competitive figure of merit (FoM) of 0.47 pJ/conversion-step among other high-resolution ADCs used in ultrasound applications.