“…Use of real patients may result in insufficient case mix (Peabody et al, 2000) which may inadvertently introduce sampling bias, especially as it relates to MDT. The Derangement syndrome is the most common classification in the spine (78%, May, 2006) and in the extremity (37%, May & Rosedale, 2012). Because of the apparent prevalence of the Derangement syndrome, the random recruitment of patients may unintentionally create a homogenous sample that potentially would not include all relevant syndromes within the classification system.…”