A Survey of Metal Carcinogenesis1,2

Mixed bivalent transition metal complexes of 1,10-phenanthroline and 2-aminomethylthiophenyl-4-bromosalicylaldehyde Schiff base: Spectroscopic, molecular modeling and biological activities

“…The study of ternary complexes involving an aromatic Schiff base and 1,10-phenanthroline has been studied extensively [11]. It is well known that some drugs exhibit increased activity when administered as metal complexes [12][13][14] and several metal chelates have been shown to inhibit tumor growth [15]. Some research groups found that the Schiff base metal complexes derived from salicylaldehyde can specially cleave the DNA [16,17].…”

Synthesis, spectral characterization, solution equilibria, in vitro antibacterial and cytotoxic activities of Cu(II), Ni(II), Mn(II), Co(II) and Zn(II) complexes with Schiff base derived from 5-bromosalicylaldehyde and 2-aminomethylthiophene

“…It is well known that some drugs exhibit increased activity when administered as metal complexes [6][7][8] and several metal chelates have been shown to inhibit tumor growth [9]. There have been several reports on metal complexes of the Schiff base ligands having a variety of applications including biological, clinical, analytical and industrial in addition to their important roles in catalysis and organic synthesis [10][11][12][13][14].…”

Toxicity and mutual interactions of cadmium and zinc ions in normal and carcinogen-transformed mouse cells

“…On the other hand, the metabolism of these metal ions, their sites of regulation, and their overall regulatory functions are as yet poorly understood. This is true despite the fact that a number of studies have been carried out on the biological consequences of high concentrations of bivalent metal ions, including studies of toxicity (Fassett, 1975;Sunderman, 1977), mutagenicity (Ochi and Ohsawa, 1983), malignant transformation in vitro (DiPaolo and Casto, 1979) and tumor induction (Furst and Haro, 1969;Sunderman, 1977).…”