A survey of interactions in crystal structures of pyrazine-based compounds

Abstract

The important role of pyrazine (pz) and its derivatives in fields such as biochemistry and pharmacology, as well as in the study of magnetic properties, is surveyed. Recognition of these properties without extensive investigations into their structural properties is not possible. This review summarizes interactions that exist between these organic compounds by themselves in the solid state, as well as those in coordination polymers with metal ions and in polyoxometalatebased hybrids. Complexes based on pyrazine ligands can generate metal-organic framework (MOF) structures that bind polyoxometalates (POMs) through covalent and noncovalent interactions. Some biological and magnetic properties involving these compounds are considered and the effect of hydrogen bonding on their supramolecular architectures is highlighted. feature articles 232 Taghipour and Mirzaei A survey of interactions of pyrazine-based compounds Acta Cryst. (2019). C75, 231-247 feature articles 234 Taghipour and Mirzaei A survey of interactions of pyrazine-based compounds Acta Cryst. (2019). C75, 231-247 feature articles Acta Cryst. (2019). C75, 231-247 Taghipour and Mirzaei A survey of interactions of pyrazine-based compounds 237 Figure 9Structure of [Cu 2 (PZOAPZ-H)Br 3 (H 2 O) 2 ]. Reproduced from Grove et al. (2004) with permission. feature articles Acta Cryst. (2019). C75, 231-247 Taghipour and Mirzaei A survey of interactions of pyrazine-based compounds 245

Synthesis, structure and bioactivity of Ni2+ and Cu2+ acylhydrazone complexes

“…These ligands feature the N,N 0 ,O-coordination mode via one of the pyrazine N, the imine N and the iminol O atoms. In general, pyrazine derivatives have been found to have great importance in biochemistry courtesy of their chemical functionality (Kenwood et al, 2015;Koleša-Dobravc et al, 2017;Taghipour & Mirzaei, 2019). In our previous report, we revealed that mononuclear Cu II complexes based on pyrazine-acylhydrazone ligands showed strong activity against jack bean urease (Qin et al, 2016).…”

Contributions of secondary alcohol–ketone O—H...O=C and furan–acetate Csp 2—H...OOC synthons to the supramolecular packings of two bioactive molecules

“…Like many reports where intermolecular interactions are investigated on the basis of geometrical considerations (Le et al, 2015;Galek et al, 2014;Vahdani Alviri et al, 2020;Sabbaghi et al, 2021;Bojarska et al, 2020;Taghipour & Mirzaei, 2019), the CSD was used via ConQuest software (Version 5.42 of November 2020; Groom et al, 2016). For 1 and 2, the occurrence percentages of a synthon in both crystals were determined together with the number of hits having this synthon and the number of hits having the considered moieties.…”

Roles of Organic Fragments in Redirecting Crystal/Molecular Structures of Inorganic–Organic Hybrids Based on Lacunary Keggin-Type Polyoxometalates

“…One of the promising approaches toward the synthesis of this kind of material is combining metal-substituted POMs with organic or metal–organic fragments to make inorganic–organic hybrid-based LPOMs. Various POM-based inorganic–organic hybrids with interesting structural and functional properties were reported [ 23 , 24 , 25 ]. In this field, a certified fact is that the synthesis of such hybrids depends on the selection of POMs as inorganic building blocks and organic ligands as structure-directing and functional components.…”