A survey of horse owners in Great Britain regarding horses in their care. Part 2: Risk factors for recurrent airway obstruction

Hotchkiss, J. W.; Reid, S. W. J.; Christley, Robert M.

doi:10.2746/042516407x180129

Cited by 97 publications

(87 citation statements)

References 31 publications

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“…The study was performed in client-owned horses of diverse ages, breeds and disciplines representative of the general veterinary registered equine population [17][18][19]. The study was performed in client-owned horses of diverse ages, breeds and disciplines representative of the general veterinary registered equine population [17][18][19].…”

Section: Discussionmentioning

confidence: 99%

Does oral prednisolone treatment increase the incidence of acute laminitis?

Jordan¹,

Ireland

Rendle³

2016

Equine Veterinary Journal

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Section: Discussionmentioning

confidence: 99%

Does oral prednisolone treatment increase the incidence of acute laminitis?

Jordan¹,

Ireland

Rendle³

2016

Equine Veterinary Journal

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“…Cough can occur at rest or even more frequently early during exercise,39 but the absence of reported or observed cough does not rule out IAD 39, 40. Questionnaires were found to be effective in identifying cases of severe airway inflammation like RAO,8, 39, 40 whereas their usefulness for distinguishing IAD‐affected horses from controls, based on owner‐reported clinical history, seems limited 39, 40. Thoracic auscultation usually does not reveal abnormalities, but some IAD‐affected horses can exhibit increased breath sounds or subtle wheezes, particularly during rebreathing maneuvers 27, 36…”

Section: Clinical Signsmentioning

confidence: 99%

“…Clinical signs and airway obstruction can be reversed by administration of corticosteroids, bronchodilators, or changing the environment 4, 5, 6. Recurrent airway obstruction principally affects horses over 7 years of age 7, 8. In contrast, IAD can affect horses of all ages and clinical signs are usually subtle, including poor performance and occasional coughing but with normal breathing at rest 9, 10, 11, 12.…”

mentioning

confidence: 99%

Inflammatory Airway Disease of Horses—Revised Consensus Statement

Couëtil

Cardwell

Gerber

et al. 2016

Veterinary Internal Medicne

338

662

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“…IAD and EIPH also play a role in warmbloods, nevertheless, the most common lower airway disease in these horses is Recurrent airway obstruction (RAO). The estimated prevalence in the northern hemisphere is about 10-20% (Hotchkiss et al 2007) with incidence and severity of the disease increasing with age and stabling, so that RAO is a common reason for the career's end in the performance horse (Deegen 1986, Lekeux andDuvivier 2004).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic value of inflammatory markers in chronic respiratory disease of the horse – a review

Barton¹,

Shety²,

Wirth³

et al. 2014

PHK

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Summary: Over the last years local and systemic inflammatory markers of chronic pneumopathies have gained increasing interest in research, as the pathogenesis of Recurrent airway obstruction (RAO) and Inflammatory airway disease (IAD) remains not fully elucidated in several details. In human medicine, Asthma bronchiale and Chronic obstructive pulmonary disease (COPD) have been found to be influenced by systemic inflammatory processes and the other way around. Inflammation, coagulation and fibrinolysis as well as extracellular remodeling show close interactions. Cytology of bronchoalveolar lavage fluid and tracheal wash is commonly used to evaluate the severity of local inflammation in the lung. Interleukins involved in the chemotaxis of neutrophils like Interleukin 8, 17 and 23 have been studied. Chronic obstructive pneumopathies lead to remodeling of bronchial walls and lung parenchyma, ultimately causing fibrosis. Matrix-metalloproteinases (MMPs) are discussed as the most important proteolytic enzymes during remodeling in human medicine. In the horse, MMP 9 seems to be a central player in chronic respiratory disease as well. A systemic involvement has been shown for RAO by increased acute-phaseproteins like serumamyloid A and haptoglobin in peripheral blood during exacerbation. Studies focusing on these and further possible inflammatory markers for chronic respiratory disease in the horse are discussed in this review of literature.Keywords: Inflammatory markers / horse / respiratory disease / recurrent airway obstruction / RAO / Diagnostischer Wert verschiedener Entzündungsmarker bei chronischen Atemwegserkrankungen des Pferdes -eine ÜbersichtIn den letzten Jahren häufen sich Untersuchungen zu verschiedenen lokalen und systemischen Entzündungsmarkern bei chronischen Pneumopathien des Pferdes, da das Verständnis der Pathogenese von Recurrent airway obstruction (RAO) und Inflammatory airway disease (IAD) weiterhin nicht vollständig geklärt ist. Ein Blick in die Humanmedizin zeigt, dass das Asthma bronchiale und die Chronic obstructive pulmonary disease (COPD) durchaus in Zusammenhang stehen mit systemischen inflammatorischen Prozessen, so dass sich die lokalen Prozesse in der Lunge und systemische Entzündungsreaktionen gegenseitig beinflussen. Entzündung, Koagulation und Fibrinolyse sowie das extrazelluläre Remodelling sind eng miteinander verknüft. Zytologische Untersuchungen der bronchoalveolären Lavageflüssigkeit und des Tracheobronchialsekrets stellen die gebräuchlichste Methode dar, den Schweregrad der lokalen Entzündung zu beurteilen. Hierbei ergeben sich Zusammenhänge zu Interleukinen, die an der Chemotaxis neutrophiler Granulozyten beteiligt sind, wie beispielsweise Interleukin 8, 17 und 23. Chronisch obstruktive Pneumopathien führen langfristig zu chronischen Umbauprozessen der Bronchienwände und des Lungenparenchyms (Remodelling), die mit der Bildung von Fibrosen einhergehen. Matrix-Metalloproteinasen (MMPs) gelten in der Humanmedizin als wichtigste proteolytische Enzyme bei diesem Remodelling und auch...

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A survey of horse owners in Great Britain regarding horses in their care. Part 2: Risk factors for recurrent airway obstruction

Abstract: Recurrent airway obstruction is a significant health problem in the horse population of Great Britain. This form of epidemiological investigation highlights potential risk factors for the disease.

Cited by 97 publications

References 31 publications

Does oral prednisolone treatment increase the incidence of acute laminitis?

Does oral prednisolone treatment increase the incidence of acute laminitis?

Inflammatory Airway Disease of Horses—Revised Consensus Statement

Diagnostic value of inflammatory markers in chronic respiratory disease of the horse – a review

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