A Surgical Protocol to Mitigate the SARS-CoV-2 Transmission Using Multifocal Povidone-Iodine Applications in Lacrimal Surgeries During Coronavirus Disease 2019 (COVID-19) Pandemic

Ali, Mohammad Javed

doi:10.1097/iop.0000000000001746

Cited by 9 publications

(10 citation statements)

References 16 publications

(19 reference statements)

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“… Preoperative povidone-iodine (PVP–I) protocol for lacrimal surgies A drop of 1% PVP-I Administrated in a conjunctival cul-de-sac with contact time for 3 min against COVID-19. [ 192 ] 6. Povidone-iodine (PVP–I) 0.23%–7% solution Topical preparations exhibited virucidal activity [ 193 ] 7.…”

Section: Limitationsmentioning

confidence: 99%

Pharmaceutical assessment of polyvinylpyrrolidone (PVP): As excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition

Kurakula

Rao

2020

Journal of Drug Delivery Science and Technology

233

172

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Polyvinylpyrrolidone (PVP) is a water-soluble polymer obtained by polymerization of monomer N -vinylpyrrolidone. PVP is an inert, non-toxic, temperature-resistant, pH-stable, biocompatible, biodegradable polymer that helps to encapsulate and cater both hydrophilic and lipophilic drugs. These advantages enable PVP a versatile excipient in the formulation development of broad conventional to novel controlled delivery systems. PVP has tunable properties and can be used as a brace component for gene delivery, orthopedic implants, and tissue engineering applications. Based on different molecular weights and modified forms, PVP can lead to exceptional beneficial features with varying chemical properties. Graft copolymerization and other techniques assist PVP to conjugate with poorly soluble drugs that can inflate bioavailability and even introduces the desired swelling tract for their control or sustained release. The present review provides chemistry, mechanical, physicochemical properties, evaluation parameters, dewy preparation methods of PVP derivatives intended for designing conventional to controlled systems for drug, gene, and cosmetic delivery. The past and growing interest in PVP establishes it as a promising polymer to enhance the trait and performance of current generation pharmaceutical dosage forms. Furthermore, the scrutiny explores existing patents, marketed products, new and futuristic approaches of PVP that have been identified and scope for future development, characterization, and its use. The exploration spotlights the importance and role of PVP in the design of Povidone-iodine (PVP–I) and clinical trials to assess therapeutic efficacy against the COVID-19 in the current pandemic scenario.

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Section: Limitationsmentioning

confidence: 99%

Pharmaceutical assessment of polyvinylpyrrolidone (PVP): As excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition

Kurakula

Rao

2020

Journal of Drug Delivery Science and Technology

233

172

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“…[ 40 ] There is now growing evidence for its use during COVID-19 to reduce surgery induced viral shedding and aerosolization, especially in head and neck surgeries. [ 40 41 42 ] A detailed protocol for the use of PVP-I in lacrimal surgeries is now in place[ 43 ] and in use at the author's practice. This protocol would mitigate the transmission risk of the viruses during the lacrimal procedures in both pediatric and adult populations.…”

Section: Resultsmentioning

confidence: 99%

COVID-19 pandemic and lacrimal practice: Multipronged resumption strategies and getting back on our feet

Ali

2020

Indian J Ophthalmol

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“…21 There is growing evidence that suggests that the use of povidone-iodine on the sino-nasal and oral mucosa may disrupt the SARS-CoV-2 transmission. [22][23][24][25] There are multiple factors why povidone-iodine can be used safelyprimarily low resistance of the virus to povidone-iodine and its excellent safety profile. In addition to the use of povidone-iodine, combined multi-pronged approach starting from screening, triaging and testing strategies, utilization of personal protection equipment and surgical precautions to avoid aerosol creation have been recommended.…”

Section: Figurementioning

confidence: 99%

<p>A Survey on the Impact of COVID-19 on Lacrimal Surgery: The Asia-Pacific Perspective</p>

Nair¹,

Narayanan²,

Ali³

2020

OPTH

Self Cite

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Aim To assess the impact of the COVID-19 pandemic-related lockdown on lacrimal surgery among oculoplastic surgeons in the Asia-Pacific region. Methods An institutional board review approved anonymous electronic survey was sent out via email to oculoplastic surgeons across the Asia-Pacific region. All responses were tabulated and analysed. Results A total of 259 valid responses were received. Nearly 87% of the surgeons agreed that lacrimal procedures were associated with a high risk of COVID-19 transmission. In all, at the time of taking the survey, 151/259 (58.3%) of the surgeons were not performing any lacrimal surgeries in view of the COVID-19 pandemic and 71/259 (27.4%) of the respondents were only performing emergency lacrimal surgeries. External dacryocystorhinostomy was the most commonly performed lacrimal procedure across the region and lacrimal procedures contributed to at least 25% of the income for nearly a third of the respondents. Majority of the respondents were female (52.9%), but a significantly higher proportion of male oculoplastic surgeons were still performing lacrimal surgeries during the lockdown. Over 75% of respondents indicated that resuming lacrimal procedures is important to their practice. Conclusion The survey showed that there was a general agreement among the surveyed oculoplastic surgeons in the Asia-Pacific region that lacrimal procedures were associated with a high risk of COVID-19 transmission and over 85% of them of had either stopped performing elective lacrimal surgeries altogether or were providing only emergent care. It is likely that not performing elective lacrimal procedures, COVID-19 has financially impacted a high percentage of the surveyed oculoplastic surgeons.

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A Surgical Protocol to Mitigate the SARS-CoV-2 Transmission Using Multifocal Povidone-Iodine Applications in Lacrimal Surgeries During Coronavirus Disease 2019 (COVID-19) Pandemic

Cited by 9 publications

References 16 publications

Pharmaceutical assessment of polyvinylpyrrolidone (PVP): As excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition

Pharmaceutical assessment of polyvinylpyrrolidone (PVP): As excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition

COVID-19 pandemic and lacrimal practice: Multipronged resumption strategies and getting back on our feet

<p>A Survey on the Impact of COVID-19 on Lacrimal Surgery: The Asia-Pacific Perspective</p>

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