A surgical antiemetic protocol—implementation and evaluation

Negus, B.; Markocic, S.

doi:10.1016/j.acpain.2003.08.002

Cited by 7 publications

(4 citation statements)

References 10 publications

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“…This study was conducted to develop predictive models based on comprehensive analysis of causal factors for PONV in patients using PCA. The incidence rate of PONV was 27.7% in this study, which is lower than in the study of Negus and Markocic 3 where a rate of 52 -62% was indicated.…”

Section: Discussioncontrasting

confidence: 81%

“…Although patient-controlled analgesia (PCA) has been demonstrated to be a safe and effective method of pain control, 1,2 patients on PCA experience a high incidence (52 -62%) of post-operative nausea and vomiting (PONV). 3 After surgery, PONV has been shown to be one of the most distressing complications for patients, 4,5 with an incidence of 32 -91%. 6 -8 In addition, it has been reported that PONV increases the likelihood of incision pain, haematoma, wound dehiscence, 9 dehydration, electrolyte imbalance, hospitalization time, 10 dissatisfaction with medical care 11 and medical costs.…”

Section: Introductionmentioning

confidence: 99%

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Predictive Models for Post-operative Nausea and Vomiting in Patients Using Patient-controlled Analgesia

Lee

Yom

2007

J Int Med Res

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This study identified predictive factors for post-operative nausea and vomiting (PONV) in patients using patient-controlled analgesia (PCA) and developed five predictive model pathways to calculate the probability of PONV using decision tree analysis. The sample consisted of 1181 patients using PCA. Data were collected using: a specifically designed check-off form to collect patient-, surgery-, anaesthesia- and post-operation-related data; the Beck Anxiety Inventory to measure pre-operative anxiety; and a visual analogue scale, to measure post-operative pain. The incidence of PONV was 27.7%. Nine factors were highly predictive of PONV in our five model pathways: gender, obesity, anxiety, history of previous PONV, history of motion sickness, inhalation of nitrous oxide during operation, use of inhalational agents, starting oral fluid/food intake after operation, and post-operative pain. With these five predictive model pathways, we can predict the probability of PONV in an individual patient according to their individual characteristics.

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Section: Discussioncontrasting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Predictive Models for Post-operative Nausea and Vomiting in Patients Using Patient-controlled Analgesia

Lee

Yom

2007

J Int Med Res

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“…[4][5][6] For these reasons, PONV guidelines have been used to provide high-quality patient care while controlling costs. [6][7][8] These guidelines recommend prophylactic antiemetics for patients at medium to high risk of developing PONV, and treatment for patients who develop nausea and/or vomiting postoperatively. In 1997, the Auckland District Health Board (ADHB) developed PONV guidelines, which were published in 1998 ( Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Drug Use Evaluation of Ondansetron in Postoperative Nausea and Vomiting

Zolezzi¹,

Forbes

Bradshaw‐Leung

et al. 2007

Pharmacy Practice and Res

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Background Postoperative nausea and vomiting (PONV) may prolong patient recovery time and increase the cost of their care. Ondansetron is an effective treatment for PONV, but is more expensive than other antiemetics. The Auckland District Health Board (ADHB) PONV guidelines are a stepwise approach to anti‐emetic prescribing in which ondansetron is the last choice. Aim To investigate the patterns of ondansetron prescribing in the management of PONV at Auckland City Hospital and whether its use was in accordance with the ADHB PONV guidelines. Method A retrospective drug use evaluation of patients for whom ondansetron was prescribed, and who were admitted postoperatively to 20 adult medical and surgical wards. Results 303 patients were recruited over a 4‐week period, of whom 256 surgical patients were considered. Adherence with the ADHB PONV guidelines was higher when a reminder (an antiemetic sticker) was used than when it was not used (84% vs 76%). Use of the sticker increased the proportion of patients for whom other anti‐emetics were prescribed. There was poor identification of patients at risk of PONV and consequently limited use of prophylactic antiemetics in this group. Conclusion Although the use of antiemetic stickers was low, overall adherence to the ADHB PONV guidelines was encouraging. A number of steps were often omitted when an antiemetic sticker was not used and a significant proportion of patients received ondansetron first‐line.

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“…and the morpholino ethyl derivative(70) show the excellent affinity and selectivity and act as a full agonist and a partial agonist at the CB2 receptor and induce a concentration-dependent decline of cell capability on lymph node carcinoma of the prostate (LNCaP), cell line expressing the CB2 receptor[81]. Regarding CB2R affinity, the compounds (69 and 70) prove as compounds of interest to have a maximum affinity, with Ki values of 0.7 µM and 1.5 µM and 4.5 µM respectively[82].Saccomanni et al[83] study the synthesis of novel aryl iodonium salts used as precursors for single-stage nucleophilic[18] F radio fluorination.…”

mentioning

confidence: 99%

Recent Developments and Multiple Biological Activities Available With 1, 8-Naphthyridine Derivatives: A Review

Gurjar¹,

Pal²

2019

Int J Pharm Pharm Sci

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Within the wide range of nitrogen-containing heterocyclic compounds, the derivatives of 1,8-naphthyridine (NPTR) have gained a rising interest due to their reported versatile biological activities. The derivatives of NPTR scaffold are found to invite special interest from researchers nowadays on the significance of their manifestations of multiple attractive pharmacological activities which establish them as an effective and versatile tool in pharmaceutical chemistry and drug discovery. The diverse biological activities mainly include anti-inflammatory, antimicrobial, antiviral, anticancer, antihypertensive and analgesic activities. Novel NPTR scaffold has emerged its potency to treat neurological diseases like depression and Alzheimer's disease. Further these agents possess different inhibitory activities, such as anti-HIV, anti-osteoporotic, αvβ3 antagonism, antimalarial, platelet aggregation, anti-oxidant, anti-allergic, gastric antisecretory, anticonvulsant, epidermal growth factor receptor (EGFR) inhibition, protein kinase inhibition, ionotropic properties, β3 antagonism, phosphodiesterase 4 (PDE 4) inhibitions, adenosine receptor agonistic activity, adrenoceptors antagonism and DNA stabilizing activity, etc. In this review, we highlight the updates of different 1,8-naphthyridine derivatives and explain the key data available in the context of various biological activities of NPTR derivatives available from the literature. This may direct opportunity in researches in the synthesis of novel medicinal agents and the development of new heterocycles for modification of existing biological actions as well as evaluation of other possible pharmacological activities.

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A surgical antiemetic protocol—implementation and evaluation

Cited by 7 publications

References 10 publications

Predictive Models for Post-operative Nausea and Vomiting in Patients Using Patient-controlled Analgesia

Predictive Models for Post-operative Nausea and Vomiting in Patients Using Patient-controlled Analgesia

Drug Use Evaluation of Ondansetron in Postoperative Nausea and Vomiting

Recent Developments and Multiple Biological Activities Available With 1, 8-Naphthyridine Derivatives: A Review

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