Recent Developments and Multiple Biological Activities Available With 1, 8-Naphthyridine Derivatives: A Review

Abstract

Within the wide range of nitrogen-containing heterocyclic compounds, the derivatives of 1,8-naphthyridine (NPTR) have gained a rising interest due to their reported versatile biological activities. The derivatives of NPTR scaffold are found to invite special interest from researchers nowadays on the significance of their manifestations of multiple attractive pharmacological activities which establish them as an effective and versatile tool in pharmaceutical chemistry and drug discovery. The diverse biological activities mainly include anti-inflammatory, antimicrobial, antiviral, anticancer, antihypertensive and analgesic activities. Novel NPTR scaffold has emerged its potency to treat neurological diseases like depression and Alzheimer's disease. Further these agents possess different inhibitory activities, such as anti-HIV, anti-osteoporotic, αvβ3 antagonism, antimalarial, platelet aggregation, anti-oxidant, anti-allergic, gastric antisecretory, anticonvulsant, epidermal growth factor receptor (EGFR) inhibition, protein kinase inhibition, ionotropic properties, β3 antagonism, phosphodiesterase 4 (PDE 4) inhibitions, adenosine receptor agonistic activity, adrenoceptors antagonism and DNA stabilizing activity, etc. In this review, we highlight the updates of different 1,8-naphthyridine derivatives and explain the key data available in the context of various biological activities of NPTR derivatives available from the literature. This may direct opportunity in researches in the synthesis of novel medicinal agents and the development of new heterocycles for modification of existing biological actions as well as evaluation of other possible pharmacological activities.

Multiple organelle-targeted 1,8-naphthyridine derivatives for detecting the polarity of organelles

“…Fluorescent dyes established by nitrogen-containing heterocycles were frequently used for fluorescence imaging of cells, such as targeting specific organelles, viscosity and polarity detection and biomolecule detection. 41,42 In the domain of drug research and development, 1,8-naphthyridine derivatives were deemed to be privileged scaffolds of antimicrobial and disease therapeutic drugs, [43][44][45] while they were rarely used in the field of fluorescence imaging. Therefore, 1,8-naphthyridine was regarded as a basic scaffold for the construction of dyes, as shown in 1a-1d of Scheme 1.…”

Expeditious Sonochemical Synthesis of New 1,8-Naphthyridine Derivatives and their Inhibitory Activity on HepG2 Cell Line

“…On the other hand, the styryl derivatives (6b-d) showed moderate activities at (IC50: 0.18 and 0.25 μM). According to literature survey the compounds bearing 1,8-Naphthyridine scaffold can produce their anticancer potency via different molecular mechanisms such as; protein kinase inhibition like topoisomerase II, c-Met, VEGFR-2, EGFRPDGFR-β, apoptosis inducing effect and via enhancing the activity of different proapoptotic proteins such as caspases, p53, Bax/BCl-2 [32,33]. In addition, various 1,8-naphthyridine derivatives intercalate the adjacent base pairs of DNA resulting in inhibition of DNA duplication or transcription and suppression the growth of cancer cells [34].…”

Blue Light-Driven [4+2]-Cycloaddition: Diastereoselective Synthesis of Chromeno[4,3-b]quinoline and Chromeno[4,3-b][1,8]naphthyridine Scaffolds

“…The tetracyclic chromeno­[4,3- b ]­quinolone and chromeno­[4,3- b ]­[1,8]­naphthyridine, especially the corresponding trans , trans -structures, constitute core scaffolds broadly encountered in natural products and biologically important compounds. , Among others are tetrahydrocannabinol (antibacterial agent), daleformis (metalloprotease inhibitor), deguelin (antitumor agent) , helquinoline (antibacterial agent), L-689,560 (neuroprotectant), virantmycin (antiviral, antifungal activity), nalidixic acid (antibiotic agent), tosufloxacin (antibiotic agent), and gemifloxacin (antibiotic agent) (Figure ). In addition, tetrahydrochromeno­[4,3- b ]­quinolines showed anticancer activity against MDA-MB-231 and MCF-7 breast cancer cell lines .…”