A supplemental treatment for chemotherapy: Control simulation using a mathematical model with estimated parameters based on in vivo experiment

Paryad-Zanjani, Sasan; Mahjoob, Maryam; Amanpour, Saeid; Kheirbakhsh, Raheleh; Akhoundzadeh, M. Haji

doi:10.1016/j.ifacol.2016.12.138

Cited by 9 publications

(2 citation statements)

References 18 publications

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“…Longer minimal life span and significant inhibition of tumor growth during 15 days after solid tumor formation indicate that deuterium depletion somehow prevented rapid tumor growth at initial stage. It corresponds with data of S. Paryad-zanjani et al, that DDW consumption decreases melanoma F10 growth rate in C57Bl/6 mice within 30 days after grafting [14]. Our data demonstrate that antitumor effect of deuterium depletion gradually reduces after 25 th day since tumor inoculation.…”

Section: Discussionsupporting

confidence: 92%

Time-dependent effect of deuterium depletion on tumor growth and metastasis

Yaglova¹,

Обернихин²,

Yaglov³

et al. 2020

Russ Open Med J

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Objective ― impact of different time regimens of deuterium depletion on progression of syngeneic grafted tumor in mice was investigated. Material and Methods ― Experiment was performed on 64 C57Bl/6 mice divided into two groups with substitution of regular water for deuterium depleted water: 30 days prior to tumor cell inoculation and sinse the 1st day of inoculation. Mice taking destilled mineralized water were considered as a control group. Half of the mice were injected melanoma B16 cells subcutaneously for assessment of survival rate and tumor growth inhibition index. The other mice were intravenously injected melanoma cells for estimation of lung hematogenous metastasis. Results ― Deuterium depletion began at the day of tumor inoculation did not change the parameters of survival rate (38.83±7.69 days vs. 41.33±6.22days in the control). Tumor growth inhibition was found only at initial stage of tumor progression. Number of melanoma lung metastasis did not differ from the control values (32.30±6.12 and 28.33±5.38. consequently). The group of mice with preliminary consumption of deuterium depleted water demonstrated significantly higher survival rate (70.10±16.20 days), tumor inhibition index, and attenuation of lung metastasis (6.0±1.20). Conclusion ― Our findings demonstrate that deuterium depletion exerts antitumor effect by both inhibition of tumor growth and metastasis, but development of the effect is time-dependent.

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Section: Discussionsupporting

confidence: 92%

Time-dependent effect of deuterium depletion on tumor growth and metastasis

Yaglova¹,

Обернихин²,

Yaglov³

et al. 2020

Russ Open Med J

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“…Hadjiandreou and Mitsis (2013) formulated body weight and side effect index in the cost function for their optimization model so they could minimize toxicity in cancer treatment. Paryad-Zanjani et al (2016) used maximum tolerated dose and drug toxicity in the optimal control problem in order to avoid toxicity and side effects in the cancer patients.…”

Section: Review Of Optimal Drug Schedulingmentioning

confidence: 99%

Optimal Chemotherapy Scheduling for Non-Genetic Drug Resistance

Paryad-Zanjani

Singh

2021

Preprint

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One of the most difficult challenges in cancer therapy is the emergence of drug resistance within tumors. Sometimes drug resistance can emerge as the result of mutations and Darwinian selection. However, recently another phenomenon has been discovered, in which tumor cells switch back and forth between drug-sensitive and pre-resistant states. Upon exposure to the drug, sensitive cells die off, and pre-resistant cells become locked in to a state of permanent drug resistance. In this paper, we explore the implications of this transient state switching for therapy scheduling. We propose a model to describe the phenomenon and estimate parameters from experimental melanoma data. We then compare the performance of continuous and alternating drug schedules, and use sensitivity analysis to explore how different conditions affect the efficacy of each schedule. We find that for our estimated parameters, a continuous therapy schedule is optimal. However we also find that an alternating schedule can be optimal for other, hypothetical parameter sets, depending on the difference in growth rate between pre- drug and post-drug cells, the delay between exposure to the drug and emergence of resistance, and the rate at which pre-resistant cells become resistant relative to the rate at which they switch back to the sensitive state.

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Adaptive Robust Control Using Extended Kalman Filter for Cancer Treatment Using Optimal Chemotherapy

Mohite

Patel

2022

Proceedings of the 2nd International Conference on Recent Trends in Machine Learning, IoT, Smart Cities and Applications

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A supplemental treatment for chemotherapy: Control simulation using a mathematical model with estimated parameters based on in vivo experiment

Cited by 9 publications

References 18 publications

Time-dependent effect of deuterium depletion on tumor growth and metastasis

Time-dependent effect of deuterium depletion on tumor growth and metastasis

Optimal Chemotherapy Scheduling for Non-Genetic Drug Resistance

Adaptive Robust Control Using Extended Kalman Filter for Cancer Treatment Using Optimal Chemotherapy

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