A Summary of the molecular biology of antigenic variation in african trypanosomes

Donelson, John E.

doi:10.1590/s0074-02761988000500004

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“…This structure contains a network of small interconnected DNA minicircles and maxicircles (2,3). Many biologically important features were first discovered and characterized in trypanosomatids including programmed antigenic variation of surface glycoproteins (4–7), polycistronic transcription and trans‐splicing of pre‐RNAs (8), mitochondrial RNA editing (9), unique organelles such as glycosomes (10), the atypical usage of RNA polymerase I for developmentally regulated genes (11) and distinct metabolic pathways. Such unique biological characteristics have contributed to making trypanosomatids attractive models for pathogen research.…”

Section: Parasites With a Unique Biologymentioning

confidence: 99%

Functional genomics of trypanosomatids

Choi¹,

El-Sayed

2012

Parasite Immunology

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The decoding of the Tritryp reference genomes nearly 7 years ago provided a first peek into the biology of pathogenic trypanosomatids and a blueprint that has paved the way for genome-wide studies. Although 60-70% of the predicted protein coding genes in Trypanosoma brucei, Trypanosoma cruzi and Leishmania major remain unannotated, the functional genomics landscape is rapidly changing. Facilitated by the advent of next-generation sequencing technologies, improved structural and functional annotation and genes and their products are emerging. Information is also growing for the interactions between cellular components as transcriptomes, regulatory networks and metabolomes are characterized, ushering in a new era of systems biology. Simultaneously, the launch of comparative sequencing of multiple strains of kinetoplastids will finally lead to the investigation of a vast, yet to be explored, evolutionary and pathogenomic space.

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