A Summary of Planarian Signaling Pathway for Regenerative Medicine

Golfeshan, Farzaneh; Mosaddad, Seyed Ali; Babavalian, Hamid; Tebyanian, Hamid; Mehrjuyan, Elnaz; Shakeri, Fatemeh

doi:10.1007/s40011-021-01267-6

Cited by 3 publications

(3 citation statements)

References 30 publications

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“…Due to the poor survival rate, researchers are now studying the molecular processes involved in carcinogenesis. Carcinogenesis is a multistep process characterized by the development of various mutations and anomalies in the epigenome that affect the expression of several genes with a wide range of functions [9][10][11]. As a result of enhanced proliferation, decreased apoptosis, and increased tumor cell motility, there is initially a loss of control over the cell cycle, which results in invasion and metastasis.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Paxillin Expression in Epithelial Dysplasia, Oral Squamous Cell Carcinoma, Lichen Planus with and without Dysplasia, and Hyperkeratosis: A Retrospective Cross-Sectional Study

Aghili

Zare

Jahangirnia³

2023

Diagnostics

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Background: Paxillin is a cytoskeletal protein involved in the pathogenesis of several types of cancers. However, the roles of paxillin in epithelial dysplasia (ED), oral squamous cell carcinoma (OSCC), oral lichen planus with dysplasia (OLPD), hyperkeratosis (HK), and oral lichen planus (OLP) have remained unnoticed in the literature. This study aimed to evaluate its attainable functions in the pathogenesis and malignant transformation of potentially malignant oral epithelium and benign lesions. Methods: In this retrospective cross-sectional study, paxillin expression was investigated in 99 tissue samples, including 18 cases of OSCC, 21 ED, 23 OLP, 21 OLPD, and 16 cases of HK. The tissue sections also underwent immunohistochemical paxillin staining using 3,3-diaminobenzidine (DAB) chromogen. The intensity, location, and percentage of staining were examined across all groups. Data were analyzed using the Shapiro–Wilk test, ANOVA, Pearson chi-square, Kruskal–Wallis, and Dunn’s post hoc test. Results: The cytoplasmic percentage and intensity staining of Paxillin expression were evident in the central/suprabasal and basal/peripheral layers of all the obtained samples. The final staining score was significantly higher in OSCC and dysplasia compared to HK and OLP (p = 0.004). It was found that paxillin expression is associated with the grade of dysplastic samples (p < 0.001). Conclusion: The present study provides evidence that paxillin may be involved in the pathogenesis of OSCC and the development and progression of dysplastic tissue, since the paxillin expression was higher than that of HK and OLP.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Paxillin Expression in Epithelial Dysplasia, Oral Squamous Cell Carcinoma, Lichen Planus with and without Dysplasia, and Hyperkeratosis: A Retrospective Cross-Sectional Study

Aghili

Zare

Jahangirnia³

2023

Diagnostics

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“…Exploring functions and properties of materials for biomedical related applications are very important due to several reasons from drug design up to other types of therapies and treatments [1][2][3][4]. In this case, both investigating available compounds and innovating novel compounds are very important to be considered [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

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Density functional theory (DFT) calculations were performed to investigate the features of vitamin B3 (Vit-B3) in oil and water environments. Two up and down structural conformations were found based on the orientation of hydrogen atom of attached carboxylic acid group to pyridine scaffold, in which the up-conformation was found more suitable than the down-conformation. The models were stabilized in gas phases and 1-octanol and water solvents environments to explore the partition coefficient (LogP) for each conformation. In addition, the electronic features were investigated based on frontier molecular orbital levels. The results of this work indicated a higher suitability of formation for the up-conformation in all three environments and the highest suitability of formation of both up and down conformations in water medium. Accordingly, the LogP value was found smaller than one indicating watery tendency for the models. As a final remark, the structural and electronic features of Vit-B3 indicated insights into its development for further applications.

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“…As a result, developing new strategies of dealing with hypertension is a must for saving the human health system [25][26][27]. It is worth to mention that terms of exploring novel medications are very important for the reasons of dealing with several known and unknown diseases, in which several protocols have been always developing to overcome the medical issues [28][29][30]. Not only for the drug related issues, but also several other biomedical applications have been developed during the recent years [31][32][33].…”

Section: Introductionmentioning

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

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A Summary of Planarian Signaling Pathway for Regenerative Medicine

Cited by 3 publications

References 30 publications

Evaluation of Paxillin Expression in Epithelial Dysplasia, Oral Squamous Cell Carcinoma, Lichen Planus with and without Dysplasia, and Hyperkeratosis: A Retrospective Cross-Sectional Study

Evaluation of Paxillin Expression in Epithelial Dysplasia, Oral Squamous Cell Carcinoma, Lichen Planus with and without Dysplasia, and Hyperkeratosis: A Retrospective Cross-Sectional Study

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