A Summary of New Findings on the Biological Effects of Selenium in Selected Animal Species—A Critical Review

Hosnedlová, Božena; Kępińska, Marta; Skaličková, Sylvie; Fernández, Carlos; Ruttkay-Nedecký, Branislav; Malevu, Thembinkosi D.; Sochor, Jiří­; Baroň, Mojmí­r; Melčová, Magdalena; Zídková, J.; Kizek, René

doi:10.3390/ijms18102209

Cited by 180 publications

(145 citation statements)

References 393 publications

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“…It can regulate the G0/G1 and G 2 /M period to block B51, and activate apoptosis [55]. It was reported that p53 is a microtubule-associated protein that monitors the status of micro-tubes directly [63]. Although PTX could not induce genetic damage, it can induce formation of aneuploidy and triggers p53 response, stabilizes microtubules by promoting the distribution of microtubules, then arresting the cell cycle at G0/G1 and G 2 /M period [64].…”

Section: Discussionmentioning

confidence: 99%

Molecular Mechanism for Selective Cytotoxicity towards Cancer Cells of Diselenide-Containing Paclitaxel Nanoparticles

Zhang

et al. 2019

Int. J. Biol. Sci.

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Diselenide-containing paclitaxel nanoparticles (SePTX NPs) indicated selectivity of cytotoxicity between cancerous and normal cells in our previous work. Herein, the mechanism is revealed by molecular biology in detail. Cancer cells and normal cells were treated with the SePTX NPs and cell proliferation was measured using 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2-H-tetrazolium bromide (MTT) assay and cell morphology. Measurement of reactive oxygen species (ROS) levels and biochemical parameters were employed to monitor oxidative stress of the cells. JC-1 assay was used to detect the mitochondrial dysfunction of the cells. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) analysis was used to detect apoptosis of the cells. Immunofluorescence analysis and western blotting were employed to monitor changes in signaling pathway-related proteins. Compared with PTX, SePTX NPs has a good selectivity to cancer cells and can obviously induce the proliferation damage of cancer cells, but has no significant toxicity to normal cells, indicating that SePTX NPs has a specific killing effect on cancer cells. The results of mechanism research show that SePTX NPs can successfully inhibit the depolymerization of microtubules and induce cell cycle arrest, which is related to the upregulation of p53 and CyclinB1. Simultaneously, SePTX NPs can successfully induce oxidative stress, cause mitochondrial dysfunction, resulting in mitochondrial pathway-mediated apoptosis, which is related to the upregulation of autophagy-related protein LC3-II. On the other hand, lewis lung cancer C57BL/6 mice were used to evaluate the anti-tumor effects of SePTX NPs in vivo. Our data show that SePTX NPs exhibited high inhibiting efficiency against the growth of tumors and were able to reduce the side effects. Collectively, these data indicate that the high antitumor effect and selective cytotoxicities of SePTX NPs is promising in future cancer therapy.

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Section: Discussionmentioning

confidence: 99%

Molecular Mechanism for Selective Cytotoxicity towards Cancer Cells of Diselenide-Containing Paclitaxel Nanoparticles

Zhang

et al. 2019

Int. J. Biol. Sci.

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“…Selenite absorption is mediated by the formation of SeCys and selenoglutathione, which can then be transported across the enterocyte by corresponding transporters of amino acids and peptides (Vendeland, Deagen, & Whanger, 1992;Vendeland, Deagen, Butler, & Whanger, 1994). In addition, SeMet, despite competing with methionine, is absorbed in large quantities through its transporter, whereas selenate absorption is reduced in the presence of sulfate, and the latter occurs at much higher concentrations (Combs & Combs, 1984;Fairweather-Tait, Collings, & Hurst, 2010;Hosnedlova et al, 2017;Surai & Fisinin, 2016). JFDS-2019-0787 Submitted 5/22/2019, Accepted 7/27/2019.…”

Section: Introductionmentioning

confidence: 99%

Bioavailability Assessment of Copper, Iron, Manganese, Molybdenum, Selenium, and Zinc from Selenium‐Enriched Lettuce

Silva

Cadore

2019

Journal of Food Science

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Cu, Fe, Mn, Mo, Selenium (Se), and Zn bioavailability from selenate‐ and selenite‐enriched lettuce plants was studied by in vitro gastrointestinal digestion followed by an assay with Caco‐2 cells. The plants were cultivated in the absence and presence of two concentrations (25 and 40 µmol/L of Se). After 28 days of cultivation, the plants were harvested, dried, and evaluated regarding the total concentration, bioaccessibility, and bioavailability of the analytes. The results showed that biofortification with selenate leads to higher Se absorption by the plant than biofortification with selenite. For the other nutrients, Mo showed high accumulation in the plants of selenate assays, and the presence of any Se species led to a reduction of the plant uptake of Cu and Fe. The accumulation of Zn and Mn was not strongly influenced by the presence of any Se species. The bioaccessibility values were approximately 71%, 10%, 52%, 84%, 71%, and 86% for Cu, Fe, Mn, Mo, Se, and Zn, respectively, and the contribution of the biofortified lettuce to the ingestion of these minerals is very small (except for Se and Mo). Due to the low concentrations of elements from digested plants, it was not possible to estimate the bioavailability for some elements, and for Mo and Zn, the values are below 6.9% and 3.4% of the total concentration, respectively. For Se, the bioavailability was greater for selenite‐enriched than selenate‐enriched plants (22% and 6.0%, respectively), because selenite is biotransformed by the plant to organic forms that are better assimilated by the cells.

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“…The ability of sperm function is characterized by the sperm number and motility. Several selenoproteins, including mitochondrial capsule selenoprotein (MCSeP) and selenophosphate synthase (SPS-2) are localized in testicular tissue (5). The antioxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT) contribute to the reduction of ROS.…”

Section: Introductionmentioning

confidence: 99%

“…The deficiency in Se intake, as well as other antioxidants, resulted in a decreased activity of antioxidant capacity and increased the production of free radicals (6). The importance of Se in the body, especially in animal species, is not yet completely comprehensive and more studies on the effects of Se may show a number of new biologically important processes (5). Many studies have been done in animals and the effects of Se supplementation have often been evaluated in combination with other antioxidants, but no valid conclusions have been drawn so far.…”

Section: Introductionmentioning

confidence: 99%

Effect of Selenium and Electrical Stimulation on Sperm Parameters and Spinal Cord Repair: A Rat Model of Spinal Cord Injury

Bani

Abdolalizadeh

Lotfinia

et al. 2019

Iran Red Crescent Med J

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Background: Selenium (Se) and Electrical stimulation (ES) play an important role in maintaining the integrity of various body functions after spinal cord injury (SCI). Objectives: This study aimed to investigate the effect of Se and ES on the sperm parameters and the repair of the damaged spinal cord in a rat model. Methods: A total of 50 male Wistar rats were randomly divided into five groups (n = 10 per each group, including control, sham, SCI, Se, and ES. After SCI in the T10 space, the BBB and Von Frey test were used to evaluate the motor and sensory functions. Six weeks after the treatment, the assessment of sperm parameters was done. Results: The treatment with Se, compared to the SCI group, significantly increased the sperm concentration (38.66 ± 14.81 vs. 18.50 ± 7.02, P < 0.001), motility (55.00 ± 3.0 vs. 8.33 ± 1.16, P < 0.001) and viability (81.66 ± 8.16 vs. 19.16 ± 1.06, P < 0.001). ES compared to the SCI group, significantly increased sperm motility (60.00 ± 6.32 vs. 8.33 ± 1.16, P = 0.001) and viability (70.83 ± 9.70 vs. 19.16 ± 1.06, P < 0.001). Se and ES revealed no significant effects on sperm morphology (P > 0.05). A significant increase was observed in the BBB locomotor Score and Von Frey test in the SE and ES groups compared to the SCI group and between the Se and ES groups. However, no significant difference was observed between the Se and ES groups in the Von Frey test. Conclusions: The effect of Selenium on sperm parameters and motor function was superior than that of the Electrical stimulation, but the effective effect on repairing the sensory function was the same.

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A Summary of New Findings on the Biological Effects of Selenium in Selected Animal Species—A Critical Review

Cited by 180 publications

References 393 publications

Molecular Mechanism for Selective Cytotoxicity towards Cancer Cells of Diselenide-Containing Paclitaxel Nanoparticles

Molecular Mechanism for Selective Cytotoxicity towards Cancer Cells of Diselenide-Containing Paclitaxel Nanoparticles

Bioavailability Assessment of Copper, Iron, Manganese, Molybdenum, Selenium, and Zinc from Selenium‐Enriched Lettuce

Effect of Selenium and Electrical Stimulation on Sperm Parameters and Spinal Cord Repair: A Rat Model of Spinal Cord Injury

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