A successfully treated case of mycetoma due to Nocardia veterana

Kashima, Masato; Kano, Rui; Mikami, Yuzuru; Takahama, Hideto; Ito, Michio; Hasegawa, Atsuhiko; Mizoguchi, Masahiro

doi:10.1111/j.1365-2133.2005.06551.x

Cited by 21 publications

(13 citation statements)

References 6 publications

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“…24 In addition, case reports have described the efficacy of imipenem and amikacin combination therapy for S somaliensis and N veterana actinomycetomas. 25,26 Our study demonstrates the efficacy and tolerability of imipenem, both as monotherapy and in combination with amikacin, in the management of severe and refractory actinomycetomas. Although 50% of patients were not cured, they still had significant clinical improvement and negative culture result, which hitherto they had not achieved with previous antibiotic therapies.…”

Section: Discussionmentioning

confidence: 90%

Efficacy of imipenem therapy for Nocardia actinomycetomas refractory to sulfonamides

Ameen¹,

Arenas²,

Mercado³

et al. 2010

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 90%

Efficacy of imipenem therapy for Nocardia actinomycetomas refractory to sulfonamides

Ameen¹,

Arenas²,

Mercado³

et al. 2010

Journal of the American Academy of Dermatology

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“…The mainstay of antimicrobial therapy of nocardial infection has been sulfonamide combination. Other medications that have been used with efficacy against certain actinomycetes include dapsone, amikacin, and imipenem 31,32 . A combination therapy of amikacin, cotrimoxazole, and rifampicin has been proven effective for treatment of resistant cases of actinomycetoma 33…”

Section: Discussionmentioning

confidence: 99%

“…Other medications that have been used with efficacy against certain actinomycetes include dapsone, amikacin, and imipenem. 31,32 A combination therapy of amikacin, cotrimoxazole, and rifampicin has been proven effective for treatment of resistant cases of actinomycetoma. 33 Our case is noteworthy since it appears to be the first reported case of mycetoma associated with Nocardia otitidiscaviarum and Pseudozyma aphidis.…”

Section: Discussionmentioning

confidence: 99%

Isolation of both Pseudozyma aphidis and Nocardia otitidiscaviarum from a mycetoma on the leg

Bin¹,

Zhu²,

Xuan³

et al. 2011

Int J Dermatology

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We describe a case of mycetoma which typified the classic presentation of the disease: a male farmer with affection of the lower limbs and a history of trauma. The patient presented with a swollen right lower limb showing multiple discharging sinuses for 25 years. Histopathologically, grains were found by HE stain, and clustered yeast-like cells were observed by PAS stain. The distinctive 'dot-in-circle' sign was found through MRI. Besides Nocardia otitidiscaviarum, Pseudozyma aphidis was isolated from deep tissue culture, and the identification of the etiologic species was ascertained by DNA sequencing. Generally speaking, Nocardia otitidiscaviarum is an infrequent cause of mycetoma, and Pseudozyma species are usually isolated from plant material rather than clinical specimens. This is the first case of mycetoma from which both Nocardia otitidiscaviarum and Pseudozyma aphidis were isolated.

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“…En la actualidad, el uso de oxazolidinonas (linezolid) y carbapenémicos (imipenem) han mostrado ser efi caces en el manejo de lesiones resistentes o casos graves [13][14] . Amikacina y amoxicilina/ácido clavulánico han demostrado efectividad en diferentes comunicaciones de casos y su uso asociado a cotrimoxazol estaría indicado en casos con compromiso óseo o diseminación pulmonar [15][16][17][18] . La duración del tratamiento es variable, con un promedio de 12 meses.…”

Section: Nocardia Dassonvillei Cremaunclassified

Micetoma actinomicótico por Actinomadura madurae

Jerez

Schafer

Fich

et al. 2012

Rev. chil. infectol.

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Actinomycotic mycetoma due to Actinomadura maduraeMycetoma is a chronic, granulomatous, subcutaneous, infl ammatory lesion caused by true fungi (eumycetoma) or fi lamentous bacteria (actinomycetoma). Mycetoma commonly affects young people between 20 and 40 years old. The most common affected site is the foot. The characteristic clinical triad is tumefaction, draining sinuses and discharging grains. We report a healthy 31-year-old male, with a 6-year history of a progressive infl ammatory tumor associated with sinus tracts and granules on his left sole. Actinomycetoma was suspected. The clinical diagnosis was confi rmed by microbiological and histopathological study. Polymerase chain reaction and DNA sequencing identifi ed Actinomadura madurae. To our knowledge, this is the second case of mycetoma reported in Chile. Our report emphasizes the need to consider this diagnosis in patients with chronic granulomatous disease associated with sinus tracts, fi stulas and grains.Key words: Mycetoma, Actinomadura, Chile. Palabras clave: Micetoma, Actinomadura, Chile. IntroducciónL os micetomas son lesiones infl amatorias crónicas, granulomatosas y supurativas que pueden ser causadas por hongos (eumicetoma) o bacterias (actinomicetoma). Clínicamente se caracteriza por la formación de nódulos, abscesos, trayectos fi stulosos y zonas de fi brosis que originan una induración de consistencia leñosa. Pueden comprometer la piel, tejidos blandos, huesos y articulaciones. A través de las fístulas drenan secreción purulenta o sero-sanguinolenta con gránulos de colores y de dimensiones variables, que corresponden a microcolonias del agente causal 1 . Los micetomas causados por hongos se presentan mayoritariamente en áreas tropicales, en cambio, los actinomicetomas se pueden presentar en cualquier parte del mundo 2 . Los micetomas son más frecuentes en hombres, con una relación de 3 a 5:1 3 y los actinomicetomas producidos por Actinomadura madurae son más frecuentes en mujeres 4 . Son más comunes en individuos que se encuentran expuestos al medio ambiente por actividades al aire libre como agricultores, pastores y cazadores 5 ; sin embargo, también se puede observar en personas que trabajan en ciudades, víctimas de accidentes de tránsito o viajeros a zonas endémicas.La enfermedad usualmente afecta a adultos entre 20 y 40 años; no obstante, puede observarse en niños y ancianos en regiones endémicas 6 . No es considerada una enfermedad transmisible de animal a humano o de humano a humano.En Chile existen escasos casos descritos de etiología bacteriana [7][8] . A continuación se presenta un caso de micetoma actinomicótico causado por Actinomadura madurae. Caso clínicoPaciente varón de 31 años de edad, sin antecedentes mórbidos, proveniente de Rancagua, que consultó por una lesión plantar izquierda; con seis años de evolución, de crecimiento progresivo y doloroso, que le difi cultaba la deambulación. Trabajaba como repartidor de pizzas y no presentaba antecedentes de traumatismos o viajes al extranjero. Había recibido antimicrobianos orale...

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A successfully treated case of mycetoma due to Nocardia veterana

Cited by 21 publications

References 6 publications

Efficacy of imipenem therapy for Nocardia actinomycetomas refractory to sulfonamides

Efficacy of imipenem therapy for Nocardia actinomycetomas refractory to sulfonamides

Isolation of both Pseudozyma aphidis and Nocardia otitidiscaviarum from a mycetoma on the leg

Micetoma actinomicótico por Actinomadura madurae

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