A sub-acute oral toxicity analysis and comparative in vivo anti-diabetic activity of zinc oxide, cerium oxide, silver nanoparticles, and Momordica charantia in streptozotocin-induced diabetic Wistar rats

Shanker, Kalakotla; Jayarambabu, N.; Mohan, G. Krishna; Kumar, Girish; Pravallika, P. L.

doi:10.1039/c7ra05693a

Cited by 57 publications

(27 citation statements)

References 23 publications

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“…The efficacy of ZnO QDs in attenuating pancreatic damage in a rat model of treptozotocin-induced diabetes was also settled one year later by Kandeel et al [ 113 ]. Other comparative studies including ZnO QDs for antidiabetic studies have been performed [ 114 ]. In 2016, Abu-Risha et al went a step further and studied the antidiabetic effect of a co-administered treatment based on ZnO QDs and Vildagliptin, a standard antidiabetic drug.…”

Section: Zno Nanoplatforms For Diabetes Treatmentmentioning

confidence: 99%

ZnO Nanostructures for Drug Delivery and Theranostic Applications

2018

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In the last two decades, zinc oxide (ZnO) semiconductor Quantum dots (QDs) have been shown to have fantastic luminescent properties, which together with their low-cost, low-toxicity and biocompatibility have turned these nanomaterials into one of the main candidates for bio-imaging. The discovery of other desirable traits such as their ability to produce destructive reactive oxygen species (ROS), high catalytic efficiency, strong adsorption capability and high isoelectric point, also make them promising nanomaterials for therapeutic and diagnostic functions. Herein, we review the recent progress on the use of ZnO based nanoplatforms in drug delivery and theranostic in several diseases such as bacterial infection and cancer.

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Section: Zno Nanoplatforms For Diabetes Treatmentmentioning

confidence: 99%

ZnO Nanostructures for Drug Delivery and Theranostic Applications

2018

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“…The FE-SEM pictures show the uniform distribution of ZnO NPs and their partially spherical and cubic shape. The bio-synthesized NPs were shown to have a smooth surface due to the presence of the biological compounds (18)(19)(20).…”

Section: Fig 1 Xrd Spectrum Of Synthesized (A) Ag and (B) Znomentioning

confidence: 99%

Antibacterial and Anticancer Activities of Biogenic Synthesized Ag and ZNO NPS

Geetha*¹

2019

IJITEE

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Biogenic synthesis of Ag and ZnO nanoparticles has been proposed as an environmental friendly and cost effective method. Curcuma longa tuber extract was used to reduce silver nitrate and zinc acetate to Ag NPs and ZnO NPs. The extract acts as each reducing capping agent. Synthesis process be standardized by modifying various parameters like salt concentrations, C. longa tuber extract concentration, and temperature and incubation period. The formation of Silver and ZnO NPs was observed among color transition. The morphology of the amalgamate Ag and ZnO NPs be characterized with various experimental techniques (FESEM, TEM). The face-centered cuboidal structure of Ag and ZnO NPs be studied using X-ray optical phenomenon. Further Ag in addition to ZnO NPs were tested for antibacterial and anticancer activities.

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“…The study of the effect of drug toxicity and its side effects are other important topics addressed in our research. In that connection, a sub-acute oral toxicity analysis by zinc oxide NPs antidiabetic activity in vivo carried out by Shanker et al is noteworthy [23]. Furthermore, a study by Jacobsen et al showed that the toxicity of zinc oxide NPs appeared to be dose dependent [24].…”

Section: Introductionmentioning

confidence: 99%

ZnO Q-dots as a potent therapeutic nanomedicine for in vitro cytotoxicity evaluation of mouth KB44, breast MCF7, colon HT29 and HeLa cancer cell lines, mouse ear swelling tests in vivo and its side effects using the animal model

Fakhroueian

Vahabpour

Assmar

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Nanoformulations derived from fine porous ZnO quantum dot nanoparticles (QD NPs) can offer strong potential medical applications; especially in cancer therapy. ZnO QD NPs was synthesized by sol-gel hydrothermal process, fast cold quenching and further smart surface functionalization methods to obtain ultrasmall size (1-4 nm) NPs. ZnO nanopolymer, a wetting agent, PEG co-solvent and water/oil emulsion stabilizer were considered in our nanofluid formulation. The resulting nanofluid was characterized by SEM, FTIR, photoluminescence, band gap energy, zeta potential and UV-Vis spectroscopy. The cytotoxic effects on the growth of four cancer cell lines were evaluated by MTT assay. The IC (µg/ml) values of 30, 41, 40 and 35 for KB44, MCF-7, HT29 and HeLa cells, respectively, after 48 h of nanoformulation treatment suggested the cytotoxic effect of this nanoformulation on these cell lines in a concentration-dependent manner (p < .05). ZnO nanofluid destroyed cancer cell lines more efficiently than the normal HFF-2 (IC= 105 µg/ml). The reduction in cell viability in response to ZnO nanofluid treatment induced apoptosis in the cultured cells. Skin sensitization test plus antibacterial activity were also measured. Side effect tests on 70 white mice in vivo resulted in only 3-4 abnormal situations in hepatic tissue section possibly due to the idiosyncratic drug reactions.

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A sub-acute oral toxicity analysis and comparative in vivo anti-diabetic activity of zinc oxide, cerium oxide, silver nanoparticles, and Momordica charantia in streptozotocin-induced diabetic Wistar rats

Abstract: Type 2 diabetes mellitus (T2DM) is one of the most threatening, non-communicable ailments worldwide.

Cited by 57 publications

References 23 publications

ZnO Nanostructures for Drug Delivery and Theranostic Applications

ZnO Nanostructures for Drug Delivery and Theranostic Applications

Antibacterial and Anticancer Activities of Biogenic Synthesized Ag and ZNO NPS

ZnO Q-dots as a potent therapeutic nanomedicine for in vitro cytotoxicity evaluation of mouth KB44, breast MCF7, colon HT29 and HeLa cancer cell lines, mouse ear swelling tests in vivo and its side effects using the animal model

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