ZnO Nanostructures for Drug Delivery and Theranostic Applications

Martínez-Carmona, Marina; Gun’ko, Yurii K.; Vallet‐Regí, María

doi:10.3390/nano8040268

Cited by 187 publications

(118 citation statements)

References 133 publications

(145 reference statements)

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“…Selective doping that enables controlling the semiconductor properties of ZnO, such as conductivity or forbidden band, has made it an interesting material for potential application in electronics, spintronics and optoelectronics. The biocompatibility, antibacterial and antifungal action of ZnO are the reasons it enjoys large interest in pharmacy and biomedicine [ 3 , 4 , 5 , 6 , 7 , 8 , 9 ]. It is a common ingredient of everyday products, e.g., rubber, pigments, cements, plastics, paints, pharmaceutical products and cosmetics [ 10 , 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Microwave Radiation Power on the Size of Aggregates of ZnO NPs Prepared Using Microwave Solvothermal Synthesis

et al. 2018

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This paper reports the possibility of changing the size of zinc oxide nanoparticles (ZnO NPs) aggregates through a change of synthesis parameters. The effect of the changed power of microwave heating on the properties of ZnO NPs obtained by the microwave solvothermal synthesis from zinc acetate dissolved in ethylene glycol was tested for the first time. It was found that the size of ZnO aggregates ranged from 60 to 120 nm depending on the power of microwave radiation used in the synthesis of ZnO NPs. The increase in the microwave radiation power resulted in the reduction of the total synthesis time with simultaneous preservation of the constant size and shape of single ZnO NPs, which were synthesized at a pressure of 4 bar. All the obtained ZnO NPs samples were composed of homogeneous spherical particles that were single crystals with an average size of 27 ± 3 nm with a developed specific surface area of 40 m2/g and the skeleton density of 5.18 ± 0.03 g/cm3. A model of a mechanism explaining the correlation between the size of aggregates and the power of microwaves was proposed. This method of controlling the average size of ZnO NPs aggregates is presented for the first time and similar investigations are not found in the literature.

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Section: Introductionmentioning

confidence: 99%

Effect of Microwave Radiation Power on the Size of Aggregates of ZnO NPs Prepared Using Microwave Solvothermal Synthesis

et al. 2018

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“…ZnO at the bulk or micro-sized scale is classified as a GRAS—generally recognized as safe—substance by the US Food and Drug Administration (FDA) [ 47 ], but is also one of the most promising inorganic antimicrobial materials [ 48 , 49 ]. However, it can cause potential toxicity to eukaryotic cells in a dose dependent way [ 40 , 50 , 51 , 52 ].…”

Section: Resultsmentioning

confidence: 99%

Biodegradable and Drug-Eluting Inorganic Composites Based on Mesoporous Zinc Oxide for Urinary Stent Applications

et al. 2020

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Conventional technologies for ureteral stent fabrication suffer from major inconveniences such as the development of encrustations and bacteria biofilm formation. These drawbacks typically lead to the failure of the device, significant patient discomfort and an additional surgery to remove and replace the stent in the worst cases. This work focuses on the preparation of a new nanocomposite material able to show drug elution properties, biodegradation and eventually potential antibacterial activity. Poly(2-hydroxyethyl methacrylate) or the crosslinked poly(2-hydroxyethyl methacrylate)-co-poly(acrylic acid) hydrogels were prepared by the radical polymerization method and combined with a biodegradable and antibacterial filling agent, i.e., flower-like Zinc Oxide (ZnO) micropowders obtained via the hydrothermal route. The physico-chemical analyses revealed the correct incorporation of ZnO within the hydrogel matrix and its highly mesoporous structure and surface area, ideal for drug incorporation. Two different anti-inflammatory drugs (Ibuprofen and Diclofenac) were loaded within each composite and the release profile was monitored up to two weeks in artificial urine (AU) and even at different pH values in AU to simulate pathological conditions. The addition of mesoporous ZnO micropowders to the hydrogel did not negatively affect the drug loading properties of the hydrogel and it was successfully allowed to mitigate undesirable burst-release effects. Furthermore, the sustained release of the drugs over time was observed at neutral pH, with kinetic constants (k) as low as 0.05 h−1. By exploiting the pH-tunable swelling properties of the hydrogel, an even more sustained release was achieved in acidic and alkaline conditions especially at short release times, with a further reduction of burst effects (k ≈ 0.01–0.02 h−1). The nanocomposite system herein proposed represents a new material formulation for preparing innovative drug eluting stents with intrinsic antibacterial properties.

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“…Zinc oxide is a biocompatible multifunctional material with excellent piezoelectric and pyroelectric properties that can be used as a medical fluorescent material [131,132]. In addition, the low toxicity and biodegradable properties of nanomaterials in the human body are also important features of ZnO and make it a great candidate for use in cancer nanomedicine [133]. To produce compact and useful ZnO-based NPs for cancer diagnosis, Hong et al synthesized specific green fluorescent ZnO-NWs and further conjugated ZnO-NWs with the c(RGDyK) peptide to target αvβ3-integrin [130].…”

Section: Fabrication Of Integrin-targeted Nps For Cancer Diagnosismentioning

confidence: 99%

Targeting Integrins in Cancer Nanomedicine: Applications in Cancer Diagnosis and Therapy

Opadele

Onodera

et al. 2019

Cancers

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Due to advancements in nanotechnology, the application of nanosized materials (nanomaterials) in cancer diagnostics and therapeutics has become a leading area in cancer research. The decoration of nanomaterial surfaces with biological ligands is a major strategy for directing the actions of nanomaterials specifically to cancer cells. These ligands can bind to specific receptors on the cell surface and enable nanomaterials to actively target cancer cells. Integrins are one of the cell surface receptors that regulate the communication between cells and their microenvironment. Several integrins are overexpressed in many types of cancer cells and the tumor microvasculature and function in the mediation of various cellular events. Therefore, the surface modification of nanomaterials with integrin-specific ligands not only increases their binding affinity to cancer cells but also enhances the cellular uptake of nanomaterials through the intracellular trafficking of integrins. Moreover, the integrin-specific ligands themselves interfere with cancer migration and invasion by interacting with integrins, and this finding provides a novel direction for new treatment approaches in cancer nanomedicine. This article reviews the integrin-specific ligands that have been used in cancer nanomedicine and provides an overview of the recent progress in cancer diagnostics and therapeutic strategies involving the use of integrin-targeted nanomaterials.

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ZnO Nanostructures for Drug Delivery and Theranostic Applications

Cited by 187 publications

References 133 publications

Effect of Microwave Radiation Power on the Size of Aggregates of ZnO NPs Prepared Using Microwave Solvothermal Synthesis

Effect of Microwave Radiation Power on the Size of Aggregates of ZnO NPs Prepared Using Microwave Solvothermal Synthesis

Biodegradable and Drug-Eluting Inorganic Composites Based on Mesoporous Zinc Oxide for Urinary Stent Applications

Targeting Integrins in Cancer Nanomedicine: Applications in Cancer Diagnosis and Therapy

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