A Study to Correlate Total Calcium and Glycated Hemoglobin in Type-2 Diabetes Patients.

Abstract

Background: The risk for developing diabetic complications are related to glycemic control which is measured by estimating the glycated hemoglobin (HbA1c) level. Calcium increases the GLUT 4 activity. Change in calcium alters the insulin receptor phosphorylation, and decreases the activity of glucose transporter Objective: To nd out the correlation between serum Calcium and glycated Haemoglobin in Type 2 Diabetes Mellitus patients. Materials And Methodology: A cross sectional study which included 100 type 2 Diabetes mellitus patients, divided into 2 groups based on HbA1c levels. Group 1 : Type 2 Diabetic patients with HbA1c more than 7 percent and Group 2 : Type 2 Diabetic patients with HbA1c less than 7 percent. Total calcium level was correlated with glycated hemoglobin level. Statistical analysis was done using unpaired t test. Result: The mean value of serum total calcium was lower in the diabetic group whose HbA1c was > 7 (p value – 0.000) when compared to the diabetic group whose HbA1c was <7. A strong negative correlation (r = -0.391) between calcium and HbA1c in the T2 diabetic patients with HbA1c >7 (p = 0.000) was observed. Conclusion: Alteration in calcium levels will have adverse effects on insulin secretion and release. Estimating the level of calcium becomes important to know the status of insulin in diabetic patients and correlating the levels of HbA1c and Serum Calcium in Type 2 DM patients, can monitor the levels of glycemic control and the risk of development of complications. Calcium supplementation to the diabetic patients can help in better glycemic control and prevent diabetes related complications