A study to correlate histopathological findings in patients with abnormal uterine bleeding

Abstract

Background: Abnormal uterine bleeding (AUB) is a common gynecological problem associated with considerable morbidity and significantly affects the patients. The aim of the study was to analyze the histopathological patterns of endometrium in patients presenting with AUB and also to determine the incidence of AUB in various age groups.Methods: This is a retrospective study, conducted in the Department of Obstetrics and Gynaecology, in a tertiary care teaching hospital, Mumbai, India from March 2016 till date. All cases of AUB were included in the study. Data was entered in microsoft excel and managed in statistical package for the social sciences (SPSS) version 16. Analysis was done in the form of percentages and proportions and represented as tables where necessary.Results: A total of 120 cases were analyzed. Patients’ age ranged from 22-79 years. AUB was most common among the perimenopausal females (41-50years). The most common presenting symptom was heavy menstrual bleeding (53%). Dilatation and curettage (D&C) was performed in all cases and 96 underwent hysterectomy as final resort. Endometrial proliferative pattern was the most common histopathological finding and was seen in 27% patients, followed by endometrial hyperplasia in 13.5% patients, secretory endometrium (12.7%) and disordered proliferative endometrium were seen in 10.9% patients each. Malignancy was detected in 1.7% of cases and endometrial carcinoma was the most common lesion.Conclusions: Endometrial sampling is especially indicated in women above the age of 35 years to rule out malignancy and preneoplasia. Among the females with no organic pathology, normal physiological patterns with proliferative, secretory, and menstrual changes were observed. The most common endometrial pathology in this study was endometrial proliferation.

Drug utilisation pattern and risk factor assessment on abnormal uterine bleeding in reproductive aged women in a tertiary care hospital

“…In this, most of the women were belongs to the age group of 41-50 years (50%) and only (7.33%) of women belong to the age group of 13-20. Earlier studies (Shukla et al, 2017) showed that 53% of women were in the 41-50 age group compared to others, and thus, the study correlates with our study.…”

Histopathological evaluation of endometrium and its clinical correlation in patients of abnormal uterine bleeding

“…In present study most of AUB patients belonged to 41-50 year age group, multiparous and had HMB as main complaint same as Shukla et al 19 Bashir et al also found menorrhagia (56.73%) as most common presenting complaint. 20 Incidence of heavy menstrual bleeding in this age group is more common; this may be due to the fact that as women approaches menopause, decrease number of ovarian follicle and increase resistance to gonadotropic stimulation, result in anovulatory cycles.…”

A clinicopathological correlation of international federation of gynecology and obstetrics's PALM–COEIN classification of abnormal uterine bleeding: Indian scenario

“…We found that leiomyoma (AUB-L 30%) was the most common cause of AUB closely followed by adenomyosis (AUB-A, 29.66%) which was in accordance with studies by other authors. [78910] Age is suggested to be an important risk factor with a lifetime risk more than 60% in women with age over 45 years. [789]…”

“…[78910] Age is suggested to be an important risk factor with a lifetime risk more than 60% in women with age over 45 years. [789]…”

“…[7] (secretory – 41.52% and proliferative –- 37.28%) but differed with findings of Jetley et al .,[2] Deka et al .,[12] and Shukla et al . [8] where proliferative endometrium was most common. However, the percentage of cases of proliferative endometrium was similar with Deka et al .…”