A study on urinary tract infection in a tertiary care hospital

Abstract

Background: Urinary tract infection is defined as bacteriuria along with urinary symptoms. It is one of the most common bacterial infections in humans and a major cause of morbidity. UTI has become difficult to treat because of appearance of pathogens with increasing resistance to antimicrobial agents. The objective of this study was to determine the bacteriological profile of pathogens responsible for urinary tract infection and to assess the antibiotic sensitivity pattern of the causative uropathogens.Methods: This cross-sectional study was performed at the hospital of Sree Mookambika Institute of Medical Sciences, Kulasekharam during January 1, 2016 to December 12, 2016. Institutional ethical committee clearance was obtained. We surveyed 628 patients, who had clinical manifestations of UTI. Urine specimens were cultured for isolation of the microbial agents of UTI. The isolated bacteria were identified using biochemical tests. Data was entered in Microsoft Excel Version 2016.Statistical analysis was done using SPSS TRIAL VERSION 21C.Results: The commonest organism isolated overall was extended spectrum beta lactamase positive E. coli (35.5%) followed by extended spectrum beta lactamase negative E. coli and Enterococcus. Females (68.63%) were mostly affected than males in our study. The people in the age group of 41-60 years are found to be more (48.46%) affected than the people of other age groups. The most sensitive oral antibiotic to almost all organisms in our study is Nitrofurantoin followed by Cotrimoxazole and Norfloxacin and among parenteral antibiotics, Amikacin stands first followed by Piperacillin-Tazobactam and Gentamicin. Apart from the above antibiotics, Klebsiellapnemoniae also shows good response to Cefotaxime (96.15%) and Cefipime (96.15%) and Aztreonam (92.3%).Conclusions: From our study, it is observed that the most common causative organism for Urinary tract infection is found to be extended spectrum beta lactamase positive E. coli followed by Extended Spectrum Beta Lactamase negative E. coli and Enterococcus. The current status of sensitivity of common organism rests mainly on Nitrofurantoin (oral) and Amikacin, Piperacillin-Tazobactam (parenteral).

Bacterial Isolates of Urine and their Susceptibility to Antimicrobials

“…To take a broader aspect, this study was compared to another study that took place in Kulasekharam, India, 2017; the most common organism isolated overall was E. coli (35.5%), females (68.63%) were more affected than males in this study. The most sensitive antibiotics to almost all organisms were nitrofurantoin and amikacin [34]. While the results differ from a study in Ankara, Turkey 2018, where the most resistant antibiotic was ampicillin, the least resistant was amikacin.…”

Antimicrobial Susceptibility Pattern of Uropathogens at a Tertiary Care Hospital in Central India During Covid Era.

“…In our study, Klebsiella pneumoniae isolates exhibited very high sensitivity to colistin (94%); closely similar findings were observed by Shah et al, Saha et al, and Varghese et al[33,38,39]. Klebsiella pneumoniae showed These findings are comparable to similar studies conducted by Rajendran V et al, Agrawal R et al, and Shah D et al[12,16,26].…”