Turmeric, or Curcuma longa, is a popular healing herb in Ayurvedic medicine. Due to its potential health benefits, including antimicrobial properties, it is being used in herbal medicines to treat several systemic diseases, especially in the Indian subcontinent. In this review, we have given an up-to-date overview of the anti-infective properties of the turmeric plant, with a particular focus on its antibacterial activity. Published articles relevant to the research questions were searched in their database (PubMed, Scopus, Web of Science). Additionally, studies were searched through snowballing. The articles were included as per eligibility for data extraction. The included articles were assessed on quality reporting, and results were presented using descriptive analysis. This literature review aimed to illustrate the therapeutic properties of the plant “Curcuma longa”. A total of 32 publications out of 671 articles were selected through online and snowballing literature searches. Of these 32 articles, 22 were original research articles, and 9 were systematic reviews after removing the duplicates and non-eligible studies. Most of the original articles analysed were from India. In view of rapidly emerging antimicrobial resistance amongst the prevailing pathogens, the present study highlights the need to explore alternate preventive and treatment strategies that are safe, effective, and economical compared to existing methods. There is immense scope of such studies focused on the possibilities of mining the antimicrobial potential of bioactive phytochemicals derived from herbal sources like turmeric.
Objective: The purpose of this study was to study the bacteriological profile of UTI in patients attending the tertiary care hospital and to study the antimicrobial sensitivity pattern of uropathogens. Methods: This cross-sectional study was conducted after obtaining clearance from the institutional ethics committee. Clean-catch mid-stream urine samples were collected from patients symptomatic of UTIs. Samples were cultured aerobically on CLED agar. Isolates having significant growth (>105CFU/ml) were further processed for identification using standard microbiological techniques and their antimicrobial susceptibility pattern was evaluated by the Standard Kirby Bauer disk diffusion method as per CLSI 2020 guidelines. Results: A total of 480 urine samples were processed, yielding 174 isolates. Escherichia coli (42.50%) was predominant, followed by Klebsiella pneumonia, Pseudomonas aeruginosa, Staphylococcus aureus, Acinetobacter spp., Proteus spp., Providencia spp., Enterococcus spp., Citrobacter spp. and Morganella morganii. Gram-positive isolates exhibited high sensitivity towards vancomycin, linezolid, meropenem, and piperacillin tazobactum. Enteric coliforms exhibited high sensitivity towards colistin, meropenem, aminoglycosides, and piperacillin tazobactum. Non-fermenters exhibited high sensitivity towards colistin, meropenem, cefepime, and amoxycillin clavulanate. Conclusion: The rampant injudicious irrational overuse of antibiotics has led to the emergence of multi-drug resistant bugs, which is posing a serious challenge to clinicians in the management of infections. Developing therapeutic protocols guided by susceptibility profiles for tuning antibiotic therapy regimens is an important strategy in tackling this menace.
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