A Study on the Planarian Model Confirms the Antioxidant Properties of Tameron against X-ray- and Menadione-Induced Oxidative Stress

Abstract

Ionizing radiation and radiation-related oxidative stress are two important factors responsible for the death of actively proliferating cells, thus drastically reducing the regeneration capacity of living organisms. Planarian flatworms are freshwater invertebrates that are rich in stem cells called neoblasts and, therefore, present a well-established model for studies on regeneration and the testing of novel antioxidant and radioprotective substances. In this work, we tested an antiviral and antioxidant drug Tameron (Monosodium α-Luminol or 5-amino-2,3-dihydro-1,4-phthalazinedione sodium salt) for its ability to reduce the harm of X-ray- and chemically induced oxidative stress on a planarian model. Our study has revealed the ability of Tameron to effectively protect planarians from oxidative stress while enhancing their regenerative capacity by modulating the expression of neoblast marker genes and NRF-2-controlled oxidative stress response genes.

Ionizing Radiation, Antioxidant Response and Oxidative Damage: Radiomodulators

“…Combined with new genomic technologies, the planarian sensitivity to IR provides an outstanding tool for the evaluation of potential radioprotective agents [18]. In this, Tsarkova et al's study on the planarian model confirms the antioxidant properties of Tameron against X-ray-induced and menadione-induced oxidative stress [15].…”

“…Overall, this Special Issue provides the readers with an understanding of the latest advancements in the bioefficacy and/or mechanisms of action of several promising radiomodulators [ 2 , 3 , 5 , 7 , 9 , 10 , 13 , 14 , 15 , 16 ], the capacity of hyperthermia to increase cancer treatment efficacy [ 17 ], a new clinical model to evaluate the radio-induced damages [ 15 , 18 ], and novel IR biomarker technologies [ 19 , 20 ].…”

“…As a whole, these 11 research [ 2 , 3 , 7 , 9 , 13 , 14 , 15 , 16 , 18 , 19 , 20 ] and 4 review articles [ 5 , 10 , 17 , 36 ] from leading experts bring to the field exciting discussions on different aspects, new findings, and new perspectives, thus making this Special Issue an essential read for anyone interested in the impact of radiation exposure on human health.…”