A study on the outcome of neonates with sepsis at the Lagos University Teaching Hospital

Shobowale, EO; Ogunsola, F.T.; Oduyebo, OO; Ezeaka, V.C.

doi:10.14194/ijmbr.4.1.6

Cited by 8 publications

(8 citation statements)

References 8 publications

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“…Twenty studies specified the culture technique used for blood culture. Four of them used the BACTEC ® continuous monitoring blood culture system [ 25 , 26 , 29 , 33 , 50 ], one used the ‘semi-automated’ Oxoid signal system[ 41 ] while others used manual systems using glucose broth, cooked meat broth, tryptone soya broth with sodium polyanathol sulphate or unspecified broths.…”

Section: Resultsmentioning

confidence: 99%

“…pneumoniae was isolated in 22 studies and was the most common isolate in four studies where S . aureus was not the most frequent cause of sepsis[ 29 , 30 , 35 , 41 ] Escherichia coli was reported in 18 studies and accounted for less than 10% of isolates in 10 of these studies. Six studies reported bacterial agents of neonatal sepsis as either unspecified coliforms or unspecified Enterobacteriaceae.…”

Section: Resultsmentioning

confidence: 99%

“…Six studies reported bacterial agents of neonatal sepsis as either unspecified coliforms or unspecified Enterobacteriaceae. Coagulase negative Staphylococci (CoNS) were reported in 13 studies with four of these reporting isolation rates of more than 10% of the total agents of neonatal sepsis[ 29 , 37 , 43 , 44 ]. Notably, 12 studies reported significant isolation of Pseudomonas spp ( Table 4 ).…”

Section: Resultsmentioning

confidence: 99%

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Aetiology of neonatal sepsis in Nigeria, and relevance of Group b streptococcus: A systematic review

et al. 2018

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BackgroundGroup B Streptococcus (GBS) causes invasive infections in neonates and has been implicated as a cause of prelabour rupture of membranes, preterm delivery and stillbirths. The success of phase II trials of polyvalent polysaccharide GBS vaccines indicates that these infections are potentially preventable. Nigeria is the most populous country in Africa with one of the highest birth rates, one of the highest neonatal sepsis incidence rates and one of the highest mortality rates in the world. Therefore, before the possible introduction of preventive strategies such as intrapartum antibiotic prophylaxis or GBS vaccine into Nigeria, it is vital that there is accurate data on the aetiology of neonatal sepsis and on the incidence of GBS neonatal sepsis in particular. The objective of this study was to determine the incidence and aetiology of neonatal sepsis in Nigeria with a focus on GBS sepsis and also to assess the potential impact of a GBS vaccine.MethodsA literature search was conducted on the databases of African journals online, PubMed and Google Scholar for works conducted between 1987 to 2017. Case reports, reviews, and studies not stating specific culture methods or specific bacteria isolated were excluded. Data extracted included; incidence of neonatal sepsis, method of blood culture, blood volume, sample size, bacterial agents isolated and history of antibiotic use. PRISMA guidelines were followed and modified Down’s and Black criteria used to evaluate the quality of studies.ResultsA total of 5,114 studies were reviewed for neonatal sepsis out of which 24 consisting of a total of 2,280 cases were selected for final review. Nine studies met criteria for assessment of hospital based incidence of neonatal sepsis representing 31,305 hospital births. The incidence of neonatal sepsis was 18.2/1000 livebirths with range from 7-55/1000 livebirths while the GBS incidence was 0.06/1000 livebirths with range from 0-2/1000 live births. We discovered various limitations such as identification techniques that could result in underestimation of the true incidence of GBS sepsis. Pathogens such as Klebsiella pneumoniae and Staphylococcus aureus were more commonly isolated than GBS.Implications of key findingsThe hospital based incidence of neonatal sepsis was high at 18.2/1000 live births while that due to GBS was 0.06/1000 live births. The burden of neonatal sepsis, including that attributable to GBS is substantial and could be reduced by preventive strategies such as intrapartum antibiotic prophylaxis or GBS vaccine. There is however very sparse meaningful data currently. Well planned prospective studies with larger sample sizes, more advanced isolation and identification techniques and those following up invasive disease cases for possible short and long term sequelae are needed—not only prior to possible introduction of the vaccine to determine the baseline epidemiology, but also thereafter to monitor its impact on the population. Strategies need to be developed to also reduce the morbidity and mortality attributa...

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Aetiology of neonatal sepsis in Nigeria, and relevance of Group b streptococcus: A systematic review

et al. 2018

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“…Neonates are known to be deficient in humoral and cell-mediated immunity due to the relative immaturity of their immune systems and nonexposure to infectious agents, and in addition, studies have proven that they produce immunoglobulins at a lower rate when compared to adults. [ 4 ]…”

Section: Introductionmentioning

confidence: 99%

Neonatal sepsis in a Nigerian private tertiary hospital: Bacterial isolates, risk factors, and antibiotic susceptibility patterns

et al. 2017

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Background/Objectives:Neonatal sepsis is an important cause of morbidity and mortality in the pediatric age group in spite of several attempts at mitigating its effects. This article determines the prevalence of neonatal sepsis and the pathogens responsible for sepsis as well as risk factors and outcome at the Babcock University Teaching Hospital.Methods:A retrospective analysis of laboratory records of consecutive babies delivered within and outside our hospital suspected of having sepsis over a 1-year period.Results:The isolation rate was 34% from 100 neonates with the predominant pathogens being coagulase-negative staphylococci (CONS), Staphylococcus aureus, and Klebsiella pneumoniae. The risk factors for sepsis were age <3 days (P = 0.03) and prematurity (P < 0.001). The mortality rate was 12% with risk factors for mortality being birth weight <2500 g (P = 0.005), prematurity (P = 0.036), premature rupture of membranes (P = 0.007), and delivery outside a tertiary hospital (P = 0.007). Meropenem, ciprofloxacin, and amikacin showed the highest rates of in vitro efficacy.Conclusion:We highlight the prevalent pathogens in our local facility to be a combination of CONS, S. aureus, and K. pneumoniae with susceptibility patterns showing meropenem, ciprofloxacin, and amikacin to be our most effective antimicrobials in vitro.

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“…Newborn period is the most vulnerable period in life due to the relative deficiency of both cellular and humoral immunity compared to older ages. [1] This deficiency puts the newborn at risk of succumbing to certain morbidities, including sepsis. The burden of sepsis in the newborn is high, accounting for 36% and 30-50% of neonatal deaths globally and in the developing countries, respectively.…”

Section: Introductionmentioning

confidence: 99%

Bacterial Profile and Antibiogram of Neonatal Sepsis in Nigeria; A Review of Literatures

Ekwochi¹

2020

Anatol JFM

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A study on the outcome of neonates with sepsis at the Lagos University Teaching Hospital

Cited by 8 publications

References 8 publications

Aetiology of neonatal sepsis in Nigeria, and relevance of Group b streptococcus: A systematic review

Aetiology of neonatal sepsis in Nigeria, and relevance of Group b streptococcus: A systematic review

Neonatal sepsis in a Nigerian private tertiary hospital: Bacterial isolates, risk factors, and antibiotic susceptibility patterns

Bacterial Profile and Antibiogram of Neonatal Sepsis in Nigeria; A Review of Literatures

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