A study on the impact of HPMC viscosity grade and proportion on the functional properties of co-freeze-dried mannitol-HPMC cushioning excipients for compacted MUPS

Siow, Carin Ru Shan; Heng, Paul Wan Sia; Chan, Lai Wah

doi:10.1016/j.ejpb.2020.04.001

Cited by 7 publications

(9 citation statements)

References 20 publications

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“…On the other hand, the addition of HPMC in the formulation improved the tensile strength of T3 by more than twofold compared to the control. This result is consistent with those of Siow et al [ 81 ] who found out that incorporating HPMC showed positive contribution to mannitol tablets’ strength.…”

Section: Resultssupporting

confidence: 93%

Section: Resultssupporting

confidence: 82%

“…Even though showing some slight delay in disintegration at the 120th minute, the overall behaviour is still better than T1 and T2. Similar dissolution behaviour of other HPMC incorporated tablets such as mineral salt tablet and mannitol tablet were reported in the literature [81,85]. In general, based on the tensile strength, disintegration time and dissolution profile, T3 portrayed the best performance, followed by T1 and T2.…”

Section: Tensile Strength Disintegration Time and Dissolution Profilesupporting

confidence: 80%

“…The addition of polymer in the EFB-H tablet had modified the tablet properties substantially. Despite the promising results, the tensile strength of T3 is still meagre (0.243 MPa) compared to other HPMC bound tablets reported elsewhere (0.16 to 1.75 MPa) [81,86]. Hence, improvements should be made to enhance the tablet strength further.…”

Section: Tensile Strength Disintegration Time and Dissolution Profilementioning

confidence: 89%

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Innovative Method for Longer Effective Corrosion Inhibition Time: Controlled Release Oil Palm Empty Fruit Bunch Hemicellulose Inhibitor Tablet

et al. 2021

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This study aims to develop a controlled release oil palm empty fruit bunch hemicellulose (EFB-H) inhibitor tablet for mild steel in 1 M HCl. As plant extracts tend to deteriorate at longer immersion time, limiting its industrial applicability, we attempted to lengthen the inhibition time by forming a controlled release inhibitor tablet. Electrochemical methods (potentiodynamic polarization (PDP) and electrochemical impedance spectroscopy (EIS)) were employed to investigate the efficiency and mechanism of the inhibition. An optimum dosage and immersion time was determined via Response Surface Methodology (RSM). EFB-H tablet was formulated using D-optimal mixture design, and its anticorrosion action at extended immersion time was compared with EFB-H powder. PDP measurement revealed that EFB-H is a mixed type inhibitor. RSM optimization unveiled that the optimum point for a maximum inhibition efficiency (87.11%) was at 0.33 g of EFB-H and 120 h of immersion time. Tablet T3 with EFB-H to gum Arabic to hydroxypropyl methylcellulose ratio of 66:0:34 portrayed the best tensile strength (0.243 MPa), disintegration time (152 min) and dissolution behavior. EFB-H tablet exhibited a longer-lasting inhibition effect than powder, which was 360 h as compared to 120 h for powder. Overall, EFB-H tablet has been successfully developed, and its enhanced effective inhibition time has been experimentally proven.

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Section: Resultssupporting

confidence: 93%

Section: Resultssupporting

confidence: 82%

Section: Tensile Strength Disintegration Time and Dissolution Profilesupporting

confidence: 80%

Section: Tensile Strength Disintegration Time and Dissolution Profilementioning

confidence: 89%

See 2 more Smart Citations

Innovative Method for Longer Effective Corrosion Inhibition Time: Controlled Release Oil Palm Empty Fruit Bunch Hemicellulose Inhibitor Tablet

et al. 2021

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“…The inert excipients in the form of powders (49, 50), granules (51,52) or pellets (26,53) are also used as fillers for tableting pellets in the literature. The produced pellets were found to be very similar in size, characterized by a low SD value, suggesting a narrow particle size distribution.…”

Section: Physical Characterization Of Particlesmentioning

confidence: 99%

Comparative Evaluation of Pellet Cushioning Agents by Various Imaging Techniques and Dissolution Studies

et al. 2020

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Most of the commercially available pharmaceutical products for oral administration route are marketed in the tablet dosage forms. However, compression of multiparticulate systems is a challenge for the pharmaceutical research and industry, especially if the individual unit is a coated particle, as the release of the active ingredient depends on the integrity of the coating. In the present study, polymer-coated pellets tableted with different types of excipients (powder, granules, pellets) then were investigated by various tablet-destructive (microscopic) and tablet non-destructive (microfocus X-ray; microCT) imaging methods. The information obtained from the independent evaluation of the in vitro drug release profiles model is confirmed by the results obtained by image analysis, regardless of whether X-ray or stereomicroscopic images of the coated, tableted pellets were used for image analysis. The results of this study show that the novel easy-to-use, fast, and non-destructive MFX method is a good alternative to the already used microscopic image analysis methods regarding the characterization of particulates, compressed into tablets.

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Updates on applications of low-viscosity grade Hydroxypropyl methylcellulose in coprocessing for improvement of physical properties of pharmaceutical powders

Jin

Yang

et al. 2023

Carbohydrate Polymers

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A study on the impact of HPMC viscosity grade and proportion on the functional properties of co-freeze-dried mannitol-HPMC cushioning excipients for compacted MUPS

Cited by 7 publications

References 20 publications

Innovative Method for Longer Effective Corrosion Inhibition Time: Controlled Release Oil Palm Empty Fruit Bunch Hemicellulose Inhibitor Tablet

Innovative Method for Longer Effective Corrosion Inhibition Time: Controlled Release Oil Palm Empty Fruit Bunch Hemicellulose Inhibitor Tablet

Comparative Evaluation of Pellet Cushioning Agents by Various Imaging Techniques and Dissolution Studies

Updates on applications of low-viscosity grade Hydroxypropyl methylcellulose in coprocessing for improvement of physical properties of pharmaceutical powders

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