Updates on applications of low-viscosity grade Hydroxypropyl methylcellulose in coprocessing for improvement of physical properties of pharmaceutical powders

Jin, Cheng; Wu, Fei; Yang, Hong; Shen, Lan; Lin, Xiao; Zhao, Lihua; Feng, Yi

doi:10.1016/j.carbpol.2023.120731

Cited by 19 publications

(11 citation statements)

References 144 publications

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“…Formulating these excipients in the same volume of solvent would result in higher feedstock viscosity. This is believed to impact the atomisation efficiency in the spray nozzle, leading to larger droplet sizes, which increase the mean particle size of the dried powders [ 44 ]. There are conflicting reports on the effect on the particle size distribution.…”

Section: Resultsmentioning

confidence: 99%

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Bulk Flow Optimisation of Amorphous Solid Dispersion Excipient Powders through Surface Modification

Suhaidi,

Dong,

Wynne

et al. 2023

Pharmaceutics

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Particulate amorphous solid dispersions (ASDs) have been recognised for their potential to enhance the performance of various solid dose forms, especially oral bioavailability and macromolecule stability. However, the inherent nature of spray-dried ASDs leads to their surface cohesion/adhesion, including hygroscopicity, which hinders their bulk flow and affects their utility and viability in terms of powder production, processing, and function. This study explores the effectiveness of L-leucine (L-leu) coprocessing in modifying the particle surface of ASD-forming materials. Various contrasting prototype coprocessed ASD excipients from both the food and pharmaceutical industries were examined for their effective coformulation with L-leu. The model/prototype materials included maltodextrin, polyvinylpyrrolidone (PVP K10 and K90), trehalose, gum arabic, and hydroxypropyl methylcellulose (HPMC E5LV and K100M). The spray-drying conditions were set such that the particle size difference was minimised, so that it did not play a substantial role in influencing powder cohesion. Scanning electron microscopy was used to evaluate the morphology of each formulation. A combination of previously reported morphological progression typical of L-leu surface modification and previously unreported physical characteristics was observed. The bulk characteristics of these powders were assessed using a powder rheometer to evaluate their flowability under confined and unconfined stresses, flow rate sensitivities, and compactability. The data showed a general improvement in maltodextrin, PVP K10, trehalose and gum arabic flowability measures as L-leu concentrations increased. In contrast, PVP K90 and HPMC formulations experienced unique challenges that provided insight into the mechanistic behaviour of L-leu. Therefore, this study recommends further investigations into the interplay between L-leu and the physico-chemical properties of coformulated excipients in future amorphous powder design. This also revealed the need to enhance bulk characterisation tools to unpack the multifactorial impact of L-leu surface modification.

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Section: Resultsmentioning

confidence: 99%

“…This may be consistent with the differences in the L-leu formation and the alternative form on the surface. HPMC is a known viscosity-modifying material [ 44 ]. Feng et al reported that viscosity may play a role in hindering the ability of L-leu to form a crystalline shell [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Bulk Flow Optimisation of Amorphous Solid Dispersion Excipient Powders through Surface Modification

Suhaidi,

Dong,

Wynne

et al. 2023

Pharmaceutics

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“…[39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58] Polymers like HEMC, HPMC, HPG, and HEC are partially-synthetic WSPs that alter paste and mortar viscosity and rheology. [59][60][61][62][63][64][65][66][67][68][69][70][71][72][73][74][75][76][77] Protein-based WSPs are widely utilized in various industries due to their unique properties such as water solubility, compatibility with biological systems, degradability, affordability, and antioxidant and antibacterial properties. [78][79][80][81][82][83][84][85][86][87]…”

Section: Introductionmentioning

confidence: 99%

“…Adhesives, films, coatings, and cement thickening agents use synthetic WSPs such as PVA, PAM, PEO, polyethylene glycol (PEG), and PPA 39–58 . Polymers like HEMC, HPMC, HPG, and HEC are partially‐synthetic WSPs that alter paste and mortar viscosity and rheology 59–77 . Protein‐based WSPs are widely utilized in various industries due to their unique properties such as water solubility, compatibility with biological systems, degradability, affordability, and antioxidant and antibacterial properties 78–92 …”

Section: Introductionmentioning

confidence: 99%

Review of advanced cementitious composites using water soluble polymer based admixture

Nitin,

Chaudhary,

Yeshpal

2024

J of Applied Polymer Sci

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This paper offers a thorough unfolding of the many contributions that water‐soluble polymers (WSPs) play in cementitious composites. The several forms of WSPs—natural, semi‐synthetic, and artificial—are examined, and their methods of action in cementitious composites are investigated. The topics of binding, association, adhesion, complexation, and bridge creation are covered in the literature. The effects of WSPs on the microstructure, freshness, mechanical properties, and durability of cement‐based goods are also investigated in this review. The advantages and disadvantages of utilizing WSPs in cement‐based products are also discussed. Following a detailed analysis of the most significant findings, recommendations are made for both academic and practical research areas and applications. This study provides useful information for both experts and novices by elucidating the multi‐applications of WSPs in cementitious materials.

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“…The powder of traditional Chinese medicine(TCM) extract was obtained by various drying methods, which was used as raw material of TCM preparation. The chemical composition of TCM powder is complex, which leads to diverse physical properties of TCM extract powder, and these properties such as viscosity, moistening property, uidity and compressibility have an impact on subsequent preparation process of TCM extract powder (Jin et al, 2023;Zhu et al, 2022). The development of TCM preparation has a stronger demand for the physical modi cation technology of powder, and puts forward higher requirements for the precise selection of modi ed excipient, and the demand for high-e ciency and universal modi ed excipient is more urgent.…”

Section: Introductionmentioning

confidence: 99%

Study on Low Viscosity Hydroxypropyl Methylcellulose Obtained by Electron Beam Irradiation and Its Role in Powder Modification

Cheng,

Wang,

Hong

et al. 2023

Preprint

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In this study, hydroxypropyl Methylcellulose (HPMC) with lower viscosity was obtained by electron beam irradiation (EBI), and its physical modifiers for pharmaceutical powders was investigated when it was used during spray drying. After HPMC was irradiated at a dose of 150 kGy, the main structure of HPMC was not affected, and the substitution degree of methoxy and hydroxypropyl was not destroyed significantly. As the irradiation dose increased from 10 to 150 kGy, the molecular weight and viscosity of HPMC decreased continuously. The results of spray drying showed that HPMC could quickly migrate to the surface of the liquid medicine to cover droplets during spray drying and atomization, which improved the hygroscopicity and increased the softening point of spray-dried powder. And the powder water content is lower. After the powder is prepared into particles, the dissolution rate of particles is faster. Therefore, the modified powder exhibits better physical properties. The low viscosity HPMC obtained by electron beam irradiation is suitable for powder modification materials during spray drying, and is expected to be developed as excipient in traditional Chinese medicine and other industries.

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Updates on applications of low-viscosity grade Hydroxypropyl methylcellulose in coprocessing for improvement of physical properties of pharmaceutical powders

Cited by 19 publications

References 144 publications

Bulk Flow Optimisation of Amorphous Solid Dispersion Excipient Powders through Surface Modification

Bulk Flow Optimisation of Amorphous Solid Dispersion Excipient Powders through Surface Modification

Review of advanced cementitious composites using water soluble polymer based admixture

Study on Low Viscosity Hydroxypropyl Methylcellulose Obtained by Electron Beam Irradiation and Its Role in Powder Modification

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