A Study on the Etiology, Severity, and Mortality of 3260 Patients With Acute Pancreatitis According to the Revised Atlanta Classification in Jiangxi, China Over an 8-Year Period

Zhu, Yin; Pan, Xiaolin; Zeng, Hao; He, Wenhua; Xia, Liang; Pi, Li; Zhu, Yong; Chen, Youxiang; Lv, Nonghua

doi:10.1097/mpa.0000000000000776

Cited by 171 publications

(167 citation statements)

References 32 publications

Supporting

Mentioning

136

Contrasting

Order By: Relevance

“…In a recent study on the different etiological factors of AP, 1,914 patients were considered for the causes of their AP, and this study revealed cholelithiasis to be the primary etiology, identified in 58.7% of cases. The second most common cause was idiopathic AP, identified in 543 patients (16.7%), followed by hyperlipidemia in 467 patients (14.3%) and alcohol in 148 patients (4.5%) [6]. …”

Section: Etiology Of Apmentioning

confidence: 99%

“…It typically causes self-limiting conditions involving the gastrointestinal and respiratory systems. Several retrospective and prospective studies in the literature have demonstrated the role of Coxsackie B virus in AP, where patients manifested symptoms of AP, and the virus was identified by immunohistochemistry methods and serologic tests (antibodies against viral antigens) [6]. Recently, different serotypes of Coxsackie virus B4, such as CB4-P and CB4-V, have been found to cause both acute and chronic pancreatitis, possibly due to different immune-mediated mechanisms [17].…”

Section: Viral Causes Of Apmentioning

confidence: 99%

See 1 more Smart Citation

Review of Infectious Etiology of Acute Pancreatitis

2017

View full text Add to dashboard Cite

While gallstones and alcoholism are widely known to be the most common causative agents of acute pancreatitis, about 10% of cases are thought to be caused by infectious microorganisms. These microorganisms include viruses (e.g. mumps, Coxsackie B, and hepatitis), bacteria (e.g. Mycoplasma pneumoniae and leptospirosis), and parasites (e.g. Ascaris lumbricoides, Fasciola hepatica, and hydatid disease). Each organism causes acute pancreatitis through diverse mechanisms. The review is primarily conducted in an attempt to provide a better understanding of the possibility of acute pancreatitis presenting as a complication relating to these organisms, and the aim is to guide future diagnoses, management, and predictions of complications.

show abstract

Section: Etiology Of Apmentioning

confidence: 99%

Section: Viral Causes Of Apmentioning

confidence: 99%

Review of Infectious Etiology of Acute Pancreatitis

2017

View full text Add to dashboard Cite

show abstract

“…Hypertriglyceridemia (HTG), which is one of the three most common causes of AP, occurs in 14.3% of AP patients [2]. Compared to other etiologies, patients with hyperlipidemia acute pancreatitis (HLAP) show a higher mortality rate, more severe prognoses and more frequent local complications [3].…”

Section: Introductionmentioning

confidence: 99%

Stratified analysis and clinical significance of elevated serum triglyceride levels in early acute pancreatitis: a retrospective study

Wan

Zhu

et al. 2017

Lipids Health Dis

Self Cite

View full text Add to dashboard Cite

BackgroundHypertriglyceridemia is one of the three most common causes of AP, which is associated with the AP prognosis that has not been clearly defined.MethodsIn this retrospective study, 1539 AP patients, who had serum triglyceride (TG) levels measured within the first 72 h, were assessed. The study groups consisted of patients with normal, mild, moderate, and severe/very severe HTG levels based on the Endocrine Society Clinical Practice Guidelines. We collected baseline demographic information, laboratory values, complications, and clinical outcome data in different HTG severity groups to analyze the clinical significance of elevated TG levels in AP.ResultsOur study included 1539 AP patients; of these, 1078 (70%) had a normal TG levels, and 461 (30%) had elevated TG levels. The rates of severe AP increased in HTG groups of increasing severity (4% vs. 8% vs. 12%; P trend < 0.001). acute necrotic collection (ANC) and pancreatic necrosis developed in 32 and 39 of 112 patients (29% and 35%) (P trend = 0.001; P trend = 0.001) in the severe/very severe HTG group, respectively. The proportion of persistent organ failure (POF), multiple organ failure (MOF), and persistent Systemic Inflammatory Response Syndrome (SIRS) increased with higher grades of HTG (P trend < 0.001; P trend < 0.001; P trend < 0.001). The ICU admission rate was higher in the severe/very severe HTG group (57/112 patients; 51%; P trend < 0.001). A logistic multivariate regression analysis showed a positive correlation between HTG and certain AP complications.ConclusionIn addition to other factors, an elevated TG level could be associated with the severity and prognosis of AP, including pancreatic necrosis, POF, MOF, persistent SIRS, ICU admission, and mortality.

show abstract

Section: Introductionmentioning

confidence: 99%

“…The great majority of AP attacks are mild and resolve spontaneously with simple support, while severe local and systemic complications occur in 15–20% of cases [1, 2]. Despite progress in diagnosis and treatment, mortality in cases of severe AP is still high [1, 3]. Predicting cases that may exhibit a severe course, transferal to intensive care and early aggressive treatment can reduce mortality and morbidity in these patients [4, 5].…”

Section: Introductionmentioning

confidence: 99%

Higher Thrombin-Antithrombin III Complex Levels May Indicate Severe Acute Pancreatitis

Fidan

Erkut

Coşar

et al. 2018

Dig Dis

View full text Add to dashboard Cite

Aim: Coagulation disorders may develop in association with severe acute pancreatitis (AP). Plasma thrombin-antithrombin III complex (TAT) levels are one of the principal markers of coagulation disorder. The purpose of this study was to evaluate TAT and other hemostatic parameters in patients with AP and to examine whether or not these parameters indicate the severity of AP. Method: Forty-six patients with AP (14 severe, 32 non-severe) and a 30-member healthy control group were recruited. The severity of AP was determined using the revised Atlanta classification. ELISA was used to measure patients’ plasma TAT levels. Results: The TAT levels of AP patients at presentation were higher than those of the control group (p = 0.005). The plasma TAT levels of patients with severe AP were also significantly higher than those of patients with non-severe AP (p = 0.05) and of the control group (p < 0.001). The general accuracy, sensitivity and specificity of TAT levels in predicting the severity of AP were 77.4, 77.8, and 77.3% respectively. Conclusion: The coagulation cascade was activated in the AP patients in our study, and this was shown to become more pronounced as severity of the disease increased. Plasma TAT levels at the time of presentation in patients with AP can be used as a marker for predicting the severity of the disease.

show abstract

A Study on the Etiology, Severity, and Mortality of 3260 Patients With Acute Pancreatitis According to the Revised Atlanta Classification in Jiangxi, China Over an 8-Year Period

Cited by 171 publications

References 32 publications

Review of Infectious Etiology of Acute Pancreatitis

Review of Infectious Etiology of Acute Pancreatitis

Stratified analysis and clinical significance of elevated serum triglyceride levels in early acute pancreatitis: a retrospective study

Higher Thrombin-Antithrombin III Complex Levels May Indicate Severe Acute Pancreatitis

Contact Info

Product

Resources

About