In the grinding of thin-walled and honeycombstructured components made up of Hastelloy, undesired burrs are often created. The formed burrs negatively affect the quality of the products. Subsequent deburring increases overall manufacturing process time and cost. This work was focused on development of high-speed grinding process and grinding strategies to reduce burr size and improve ground surface quality. An electroplated Cubic Boron Nitride (CBN) wheel with miniature concave and convex asperities on its circumferential working surface was developed. Grinding performance with the designed CBN wheel was compared with a normal CBN wheel without surface asperities. Special fixtures with the function of adjusting honeycomb orientation (change of grinding direction) were purposely designed and fabricated. Design of experiment (DOE) was adopted for optimization of grinding parameters. It was found that less burr (even burrfree) grinding was achieved with the utilization of the specially designed CBN wheel with concave and convex asperities under optimal grinding conditions investigated, i.e., rotational speed of 5,000 RPM, depth of cut of 25 μm, and feed rate of 7, 500 mm/min.