A study on the corrosion behavior and biological properties of polycaprolactone/ bredigite composite coating on biodegradable Mg-Zn-Ca-GNP nanocomposite

Saberi, Abbas; Bakhsheshi-Rad, H.R.; Karamian, Ebrahim; Kasiri‐Asgarani, Masoud; Ghomi, Hamed

doi:10.1016/j.porgcoat.2020.105822

Cited by 25 publications

(20 citation statements)

References 78 publications

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“…Additionally, due to its ease of processing, nontoxicity, and high strain failure rate, PCL attracts great attention. As a result, it is used in a variety of medical applications [19]. Despite these benefits, a single PCL coating was used by a few scientists to lessen the rate of corrosion of magnesium alloys [18].…”

Section: Polycaprolactone (Pcl) Coated On Mg-based Alloymentioning

confidence: 99%

“…Such an uncontrollable and rapid corrosion mechanism causes a major decrease in the mechanical properties of the bioimplants, resulting in premature failure [15][16][17]. Furthermore, the formation of hydrogen gas and the alkalinization of microenvironments near the implant/tissue interface create serious concerns about the patient's health [18,19]. Such negative effects may cause the healing process to be slowed or even necrosis of the local tissue.…”

Section: Introductionmentioning

confidence: 99%

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A Comprehensive Review on Surface Modifications of Biodegradable Magnesium-Based Implant Alloy: Polymer Coatings Opportunities and Challenges

et al. 2021

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The development of biodegradable implants is certainly intriguing, and magnesium and its alloys are considered significant among the various biodegradable materials. Nevertheless, the fast degradation, the generation of a significant amount of hydrogen gas, and the escalation in the pH value of the body solution are significant barriers to their use as an implant material. The appropriate approach is able to solve this issue, resulting in a decrease the rate of Mg degradation, which can be accomplished by alloying, surface adjustment, and mechanical treatment. Surface modification is a practical option because it not only improves corrosion resistance but also prepares a treated surface to improve bone regeneration and cell attachment. Metal coatings, ceramic coatings, and permanent polymers were shown to minimize degradation rates, but inflammation and foreign body responses were also suggested. In contrast to permanent materials, the bioabsorbable polymers normally show the desired biocompatibility. In order to improve the performance of drugs, they are generally encapsulated in biodegradable polymers. This study summarized the most recent advancements in manufacturing polymeric coatings on Mg alloys. The related corrosion resistance enhancement strategies and future potentials are discussed. Ultimately, the major challenges and difficulties are presented with aim of the development of polymer-coated Mg-based implant materials.

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Section: Polycaprolactone (Pcl) Coated On Mg-based Alloymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Comprehensive Review on Surface Modifications of Biodegradable Magnesium-Based Implant Alloy: Polymer Coatings Opportunities and Challenges

et al. 2021

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“…The outstanding antimicrobial activity of the PCL/CS/ZnO composite coating was due to the synergistic antimicrobial properties of CS and ZnO NPs. This result in the production of reactive oxygen species (ROS) like H 2 O 2 , where CS electrostatically binds to the bacterial cell wall while ZnO NPs interact with protein membrane, resulting in the intracellular released material and perforated cell membrane [36][37][38][39][40][41][42][43][44][45][46][47][48][49][50].…”

Section: Antibacterial Studiesmentioning

confidence: 99%

Improved Bacteriostatic and Anticorrosion Effects of Polycaprolactone/Chitosan Coated Magnesium via Incorporation of Zinc Oxide

et al. 2021

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Magnesium has been recognized as a groundbreaking biodegradable biomaterial for implant applications, but its use is limited because it degrades too quickly in physiological solutions. This paper describes the research on the influence of polycaprolactone (PCL)/chitosan (CS)/zinc oxide (ZnO) composite coating (PCL/CS/ZnO) on the corrosion resistance and antibacterial activity of magnesium. The PCL/CS film presented a porous structure with thickness of about 40–50 μm, while after incorporation of ZnO into the PCL/CS, a homogenous film without pores and defects was attained. The ZnO embedded in PCL/CS enhanced corrosion resistance by preventing corrosive ions diffusion in the magnesium substrate. The corrosion, antibacterial, and cell interaction mechanism of the PCL/CS/ZnO composite coating is discussed in this study. In vitro cell culture revealed that the PCL/CS coating with low loaded ZnO significantly improved cytocompatibility, but coatings with high loaded ZnO were able to induce some cytotoxicity osteoblastic cells. It was also found that enhanced antibacterial activity of the PCL/CS/ZnO coating against both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) bacteria, while less significant antibacterial activity was detected for uncoated Mg and PCL/CS coating. Based on the results, the PCL/CS coatings loaded with low ZnO content may be recommended as a candidate material for biodegradable Mg-based orthopedic implant applications.

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“…It is worth noting that we are still a great distance from organ printing. Even though recent deposition and manufacturing systems permit us to develop structures similar to tissue in their composition, the progression of entirely functioning tissue is a much more significant step [ 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 ].…”

Section: Limitations Advantages and Future Prospects Of Alg 3d Prmentioning

confidence: 99%

Recent Trends in Three-Dimensional Bioinks Based on Alginate for Biomedical Applications

et al. 2020

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Three-dimensional (3D) bioprinting is an appealing and revolutionary manufacturing approach for the accurate placement of biologics, such as living cells and extracellular matrix (ECM) components, in the form of a 3D hierarchical structure to fabricate synthetic multicellular tissues. Many synthetic and natural polymers are applied as cell printing bioinks. One of them, alginate (Alg), is an inexpensive biomaterial that is among the most examined hydrogel materials intended for vascular, cartilage, and bone tissue printing. It has also been studied pertaining to the liver, kidney, and skin, due to its excellent cell response and flexible gelation preparation through divalent ions including calcium. Nevertheless, Alg hydrogels possess certain negative aspects, including weak mechanical characteristics, poor printability, poor structural stability, and poor cell attachment, which may restrict its usage along with the 3D printing approach to prepare artificial tissue. In this review paper, we prepare the accessible materials to be able to encourage and boost new Alg-based bioink formulations with superior characteristics for upcoming purposes in drug delivery systems. Moreover, the major outcomes are discussed, and the outstanding concerns regarding this area and the scope for upcoming examination are outlined.

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A study on the corrosion behavior and biological properties of polycaprolactone/ bredigite composite coating on biodegradable Mg-Zn-Ca-GNP nanocomposite

Cited by 25 publications

References 78 publications

A Comprehensive Review on Surface Modifications of Biodegradable Magnesium-Based Implant Alloy: Polymer Coatings Opportunities and Challenges

A Comprehensive Review on Surface Modifications of Biodegradable Magnesium-Based Implant Alloy: Polymer Coatings Opportunities and Challenges

Improved Bacteriostatic and Anticorrosion Effects of Polycaprolactone/Chitosan Coated Magnesium via Incorporation of Zinc Oxide

Recent Trends in Three-Dimensional Bioinks Based on Alginate for Biomedical Applications

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