A Study on Significance of Serum Magnesium in Migraine

Abstract

BACKGROUNDMagnesium has been implicated as a key molecule in several mechanisms of migraine pathogenesis. Central neuronal hyperexcitability is suggested to be the pivotal physiological disturbance predisposing to migraine. In this study, the role of serum magnesium in defining the physiologic threshold for migraine and modulating the various mechanisms of migraine genesis was searched for. MATERIALS AND METHODSThe study enrolled adult migraine patients of age 18 to 40 years (41 females and 29 males) with and without aura and healthy controls of the same age group. Serum magnesium levels measured in the interictal period (between attacks) in cases were compared with the results from controls. Serum calcium levels were also measured and compared in both groups. Design-Case-control study. RESULTSSerum magnesium was found to be significantly low among cases with migraine compared to controls. Serum magnesium levels showed inverse correlation with frequency of migraine attacks, implying the role of a decreased serum magnesium level in defining the susceptibility to migraine. Results also showed an association between serum magnesium and calcium levels. Serum calcium was found to be low when serum magnesium was low. CONCLUSIONMagnesium has a fundamental role in establishing the threshold for migraine headaches.

Examination of Current Treatments and Symptom Management Strategies Used by Patients With Mal De Debarquement Syndrome

“…In the open-ended comments data, Magnesium and Vitamin D were commonly mentioned. Magnesium deficiencies have been correlated to anxiety and depression ( 52 – 55 ) and migraine pathogenesis ( 56 , 57 ), with supplementation reducing the frequency of migraine attacks ( 56 , 58 , 59 ). As migraine is hypothesised to be caused by predisposed hyperactivity of the brain ( 59 ), and is often an associated symptom of MdDS ( 21 , 25 ), the addition of magnesium could be serving to combat hyperactivity within hypermetabolic regions of the MdDS brain, or perhaps reducing stress levels by interacting with various neurotransmitter and stress pathways ( 60 ).…”

Study of Serum Magnesium Levels in Migraine Patients During the Ictal and Interictal Phases

“…In migraine cases, the age of onset, length of disease, number of migraine attacks per month, average duration of headache episodes, triggering factors, aura and its kind, location, nature, severity, onset to peak latency, and accompanying symptoms were collected in detail. Using a visual analogue scale ranging from 1 (little pain) to 100 (maximal pain), the degree of pain during migraine attacks was measured [8,9]. Migraineurs' blood was drawn in the morning after a minimum of 8 h of fasting, once during their headache attack (or within 24 h following headache), and then at least 7 days after their previous migrainous headache (interictal phase).…”

“…The Kolmogorov-Smirnov test was employed to examine the data's normality. Unpaired t-test or Mann-Whitney Utest The U test was utilised to compare quantitative factors across the two groups, whereas the paired ttest/Wilcoxon test was utilised to compare quantitative variables throughout the ictal and interictal phase [9,10]. The Chi-square test and Fisher's exact test were utilised to compare qualitative data.…”