A study on serum FSH, LH and Prolactin Levels Among infertile women

Prasad, Bheem; Parmar, Dinesh; Sharma, Neeraj

doi:10.5958/2319-5886.2015.00175.7

Cited by 14 publications

(12 citation statements)

References 8 publications

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“…In the female infertile subjects, a high FSH explains the negative feedback interplay on HPG axis due to decrease in oestradiol secretion. Literature also supports a raised FSH in infertile females (Prasad, Parmar, Parmar, & Sharma, ).…”

Section: Discussionmentioning

confidence: 78%

Kisspeptin and attributes of infertile males and females: A cross‐sectional study in a subset of Pakistani population

et al. 2019

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Kisspeptin, a peptide hormone, plays a pivotal role in fertility and neuroendocrine regulation of hypothalamo–pituitary–gonadal axis. Increased kisspeptin and reproductive hormones are responsible for fertility in male and females. This study aimed to explore the role of kisspeptin on hypothalamo–pituitary–gonadal axis by comparing the levels of kisspeptin in fertile and infertile subjects and identifying single nucleotide polymorphisms (SNPs) of KISS1 gene in exon 2 and exon 3 of infertile male and female cohorts. A cross‐sectional study was carried out on 80 males (44 infertile and 36 fertile) and 88 females (44 in each group). Significantly high levels of kisspeptin (KP), follicle‐stimulating hormone (FSH), luteinizing hormone and testosterone were observed in fertile male and female subjects except low FSH levels in comparison with infertile female subjects. One polymorphism in exon 2 (E1225K [G/A 3673]) and three in exon 3 (P1945A [C/G 5833]; Insertion of T at 6075; G2026G [C/G 6078]) in infertile group were detected, with low KP and hormonal levels. Male subjects had abnormal sperm parameters and unsuccessful attempt of intracytoplasmic sperm injection in females. Expression of SNP in exon 2 and exon 3 of KISS1 could be responsible for alteration in release of reproductive hormones and gonadal functions, hence causing infertility.

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Section: Discussionmentioning

confidence: 78%

Kisspeptin and attributes of infertile males and females: A cross‐sectional study in a subset of Pakistani population

et al. 2019

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“…The serum could be the possible source of FSH in the ascites. Average serum FSH levels in postmenopausal Indian women (age 54 ± 8 years) were 62 ± 30 mIU/mL, and those in premenopausal women were 25.8 ± 10 mIU/mL [27, 28]. As shown in Table 2, ascitic FSH levels in 12 patients (patients 2, 3, 6, 10, 11, 12, 13, 14, 17, 18, 23, and 25) were >62 mIU/mL, whereas the seven patients who had low FSH in their ascites either did not have malignant cells detected in their ascites (patients 1, 8, 9, and 15) or were undergoing chemotherapy (patients 20, 21, and 24).…”

Section: Resultsmentioning

confidence: 99%

Follicle-Stimulating Hormone Is an Autocrine Regulator of the Ovarian Cancer Metastatic Niche Through Notch Signaling

Gera

Sandeep

Swamy

et al. 2018

Journal of the Endocrine Society

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The association between the upregulated Notch and FSH signaling and ovarian cancer is well documented. However, their signaling has been investigated independently and only in the primary tumor tissues. The aim of this study was to investigate the interactive effects of FSH and Notch signaling on ovarian cancer proliferation, formation, and maintenance of disseminated ovarian cancer cells. The roles of Notch and FSH in ovarian cancer pathogenesis were investigated with ovarian cancer cell lines and specific antibodies against Notch and FSH receptor (FSHR). FSH upregulated Notch signaling and proliferation in ovarian cancer cells. High levels of FSH were detected in the ascites of patients with serous ovarian adenocarcinoma. Spheroids from the patients’ ascites, as well as the spheroids from ovarian cancer cell lines under low attachment culture conditions, expressed FSHβ subunit mRNA and secreted the hormone into the medium. In contrast, primary ovarian tumor tissues and cell line monolayers expressed very low levels of FSHβ. Ovarian cancer cell spheroids also exhibited higher expression of FSH receptor and Notch downstream genes than their monolayer counterparts. A combination of FSHR and Notch antagonistic antibodies significantly inhibited spheroid formation and cell proliferation in vitro. This study demonstrates that spheroids in ascites express and secrete FSH, which regulates cancer cell proliferation and spheroidogenesis through Notch signaling, suggesting that FSH is an autocrine regulator of cancer metastasis. Furthermore, Notch and FSHR are potential immunotherapeutic targets for ovarian cancer treatment.

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“…Women with high level of prolactin may ovulate regularly but may not produce enough progesterone during luteal phase after ovulation. Deficiency of progesterone produced after ovulation, may hamper embryo implantation in a uterine lining [30,31]. Higher than the normal range of FSH and LH is rarely found in infertile women with a proper menstrual cycle but lower concentrations of these hormones have been observed [32].…”

Section: Discussionmentioning

confidence: 99%