A study on reflection of entry-level foundation course by the first year medical students

Ruprai, Reena Kaur; Ruprai, Balbir Singh

doi:10.5455/njppp.2020.10.001019202002022020

Cited by 1 publication

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“…Although not optimally detailed from the point of view of phenotyping and the description of the clinical period, the studies described here strongly emphasise the concept of increased serum MDA in asthma patients, whether adult [ 71 , 73 , 74 , 77 , 78 , 80 , 81 ], paediatric [ 72 , 75 , 76 , 79 , 82 ], during exacerbation or clinically stable. Certain factors, such as obesity and severe exacerbations themselves, were correlated with higher levels of MDA [ 74 , 75 ].…”

Section: Resultsmentioning

confidence: 99%

“…A comparison of the S-MDA levels between exacerbations and periods of stability was performed by some authors, finding higher levels during acute attacks in both adult [ 77 , 78 ] and paediatric [ 79 ] cohorts. Finally, even in the studies lacking definitions of the phenotype and clinical period of asthma patients, the S-MDA levels were higher in the patients than in the controls [ 80 , 81 ], although no correlation with lung function was found in children [ 82 ]. Moreover, one of these studies [ 80 ] showed increased MDA levels even in salivary samples.…”

Section: Resultsmentioning

confidence: 99%

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Malondialdehyde as a Potential Oxidative Stress Marker for Allergy-Oriented Diseases: An Update

et al. 2023

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Malondialdehyde (MDA) is a compound that is derived from the peroxidation of polyunsaturated fatty acids. It has been used as a biomarker to measure oxidative stress in various biological samples in patients who are affected by a wide range of diseases. The aim of our work is to provide an updated overview of the role of MDA as a marker of oxidative stress in allergy-related diseases. We considered studies involving both paediatric and adult patients affected by rhinitis, asthma, urticaria and atopic dermatitis. The measurement of MDA was performed on different types of samples. The reported data highlight the role of serum MDA in inflammatory airway diseases. According to the literature review, the oxidative stress status in asthmatic patients, assessed via MDA determination, appears to worsen in the presence of other allergic airway diseases and in relation to the disease severity. This suggests that MDA can be a suitable marker for monitoring the disease status. However, there are several limitations in the considered studies due to the different samples used and the lack of phenotyping and description of the clinical period of patients examined. In cutaneous allergic diseases, the role of MDA is controversial because of the smallness of the studies and the heterogeneity of the samples and patients.

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